Discovery of cyanopyridine scaffold as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors through virtual screening and preliminary hit optimisation

Journal of Enzyme Inhibition and Medicinal Chemistry - Tập 34 Số 1 - Trang 250-263 - 2019
Xi Xu1,2, Jie Ren1,2, Yinghe Ma1,2, Hongting Liu2, Quanjin Rong2, Yifan Feng2, Yameng Wang2, C. Yu2, Ruijia Ge3, Zhiyu Li1,2, Jinlei Bian1,2
1Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of China
2State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, People’s Republic of China;
3The Madeira School, McLean, VA, USA

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