Khám Phá Các Chất Ức Chế IDO1: Từ Thí Nghiệm Đến Lâm Sàng

American Association for Cancer Research (AACR) - Tập 77 Số 24 - Trang 6795-6811 - 2017
George C. Prendergast1, William P. Malachowski2, James B. DuHadaway1, Alexander J. Muller1
11Lankenau Institute for Medical Research (LIMR), Wynnewood, Pennsylvania.
22Department of Chemistry, Bryn Mawr College, Bryn Mawr, Pennsylvania.

Tóm tắt

Tóm tắt

Các chất ức chế phân tử nhỏ của indoleamine 2,3-dioxygenase-1 (IDO1) đang nổi lên như những tác nhân thử nghiệm hàng đầu trong lĩnh vực oncological. Tại đây, những người tiên phong của loại thuốc mới này cung cấp một bài tổng quan từ bench đến bedside về việc xác thực tiền lâm sàng của IDO1 như một mục tiêu điều trị ung thư và về việc phát hiện và phát triển một tập hợp các hợp chất khác biệt về cơ chế, bao gồm indoximod, epacadostat và navoximod, là những chất đầu tiên được đánh giá như là những chất ức chế IDO trong các thử nghiệm lâm sàng. Là các chất bổ trợ miễn dịch - chuyển hóa nhằm mở rộng cửa sổ điều trị, các chất ức chế IDO có thể khai thác không chỉ các phương thức immuno-oncology mà còn cả hóa trị và xạ trị như các tiêu chuẩn chăm sóc trong bệnh viện ung thư. Cancer Res; 77(24); 6795–811. ©2017 AACR.

Từ khóa


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