Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease

Journal of Medicinal Chemistry - Tập 51 Số 23 - Trang 7348-7351 - 2008
Scott C. Mayer1, Anthony F. Kreft1, Boyd L. Harrison1, Magid Abou‐Gharbia1, Madelene Antane1, Suzan Aschmies1, Kevin Atchison1, Michael Chlenov1, Derek C. Cole1, Thomas A. Comery1, George Diamantidis1, John W. Ellingboe1, Kristi Fan1, Rocco J. Galante1, Cathleen Gonzales1, Douglas M. Ho1, Molly Hoke1, Yun Hu1, Donna M. Huryn1, Uday Jain1, Mei Jin1, Kenneth Kremer1, Dennis Kubrak1, Melissa Lin1, Peimin Lu1, R. L. Magolda1, Robert Martone1, William Moore1, Aram Oganesian1, Menelas N. Pangalos1, Alex Porte1, Peter H. Reinhart1, Lynn Resnick1, David Riddell1, June Sonnenberg‐Reines1, Joseph R. Stock1, Shaiu-Ching Sun1, Erik Wagner1, Ting Wang1, Kevin R. Woller1, Zheng Xu1, Margaret M. Zaleska1, Joseph Zeldis1, Minsheng Zhang1, Hua Zhou1, J. Steven Jacobsen1
1Chemical and Screening Sciences, and Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, New Jersey 08543, Chemical and Screening Sciences, and Chemical Development, Wyeth Research, 401 N. Middletown Road, Pearl River, New York 10965, Drug Safety & Metabolism, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, Division of Chemical Technologies, ArQule Inc., 19 Presidential Way, Woburn, Massachusetts 01801, and Harvard University, Cambridge, Massachusetts

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Journal of Medicinal Chemistry

Tập 51 Số 23

7348-7351

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