Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

Chemistry & Biology - Tập 16 - Trang 411-420 - 2009
Kay Ahn1, Douglas S. Johnson1, Mauro Mileni2, David Beidler3, Jonathan Z. Long4, Michele K. McKinney4, Eranthie Weerapana4, Nalini Sadagopan5, Marya Liimatta6, Sarah E. Smith3, Scott Lazerwith5, Cory Stiff1, Satwik Kamtekar3, Keshab Bhattacharya3, Yanhua Zhang1, Stephen Swaney5, Keri Van Becelaere5, Raymond C. Stevens2, Benjamin F. Cravatt4
1Pfizer Global Research and Development, Groton, CT 06340, USA
2Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
3Pfizer Global Research and Development, Chesterfield, MO 63017, USA
4The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
5Pfizer Global Research and Development, Ann Arbor, MI 48105, USA
6Pfizer Global Research and Development, Cambridge, MA 02139, USA

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