Discovery, Synthesis, And Structure-Based Optimization of a Series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease

Journal of Medicinal Chemistry - Tập 56 Số 2 - Trang 534-546 - 2013
Jon Jacobs1,2,3, Valerie Grum‐Tokars4, Ya Zhou1,2,3, Mark Turlington1,2,3, S. Adrian Saldanha5, Peter Chase5, Aimee L. Eggler6, Eric S. Dawson1,2,3, Yahira M. Báez-Santos6, Sakshi Tomar6, Anna M. Mielech7, Susan C. Baker7, Craig W. Lindsley8,1,2,3, Peter Hodder5, Andrew D. Mesecar6, Shaun R. Stauffer8,1,2,3
1Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States
2Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States
3Vanderbilt Specialized Chemistry Center for Probe Development (MLPCN), Nashville, Tennessee 37232, United States
4Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, Chicago, Illinois 60607, United States
5Lead Identification Division, Translational Research Institute, Scripps Research Institute Molecular Screening Center, 130 Scripps Way, Jupiter, Florida 33458, United States
6Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, Indiana 47907, United States
7Department of Microbiology and Immunology, Loyola University Medical Center, 2160 South First Avenue, Maywood, Illinois 60153, United States
8Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232, United States

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Journal of Medicinal Chemistry

Tập 56 Số 2

534-546

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