Directed differentiation of definitive hemogenic endothelium and hematopoietic progenitors from human pluripotent stem cells

Murry, 2008, Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development, Cell, 132, 661, 10.1016/j.cell.2008.02.008 Medvinsky, 2011, Embryonic origin of the adult hematopoietic system: advances and questions, Development, 138, 1017, 10.1242/dev.040998 Kennedy, 2012, T lymphocyte potential marks the emergence of definitive hematopoietic progenitors in human pluripotent stem cell differentiation cultures, Cell Rep., 2, 1722, 10.1016/j.celrep.2012.11.003 Sturgeon, 2014, Wnt signaling controls the specification of definitive and primitive hematopoiesis from human pluripotent stem cells, Nat. Biotechnol., 32, 554, 10.1038/nbt.2915 Antas, 2013, Hemogenic endothelium: a vessel for blood production, Int. J. Biochem. Cell Biol., 45, 692, 10.1016/j.biocel.2012.12.013 Ditadi, 2015, Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages, Nat. Cell Biol., 17, 580, 10.1038/ncb3161 Conner, 2001, Mouse embryo fibroblast (MEF) feeder cell preparation, Curr. Protoc. Mol. Biol., 10.1002/0471142727.mb2302s51 Ohgushi, 2010, Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells, Cell Stem Cell, 7, 225, 10.1016/j.stem.2010.06.018 Jiang, 2013, WNT3 is a biomarker capable of predicting the definitive endoderm differentiation potential of hESCs, Stem Cell Rep., 1, 46, 10.1016/j.stemcr.2013.03.003 Bigas, 2010, The Notch pathway in the developing hematopoietic system, Int. J. Dev. Biol., 54, 1175, 10.1387/ijdb.093049ab