Direct comparison of metabolic health effects of the flavonoids quercetin, hesperetin, epicatechin, apigenin and anthocyanins in high-fat-diet-fed mice

Genes and Nutrition - Tập 10 Số 4 - 2015
E.F. Hoek–van den Hil1, Evert M. van Schothorst1, Inge van der Stelt1, Hans J. M. Swarts1, Marjanne van Vliet1, Tom Amolo1, Jacques Vervoort2, Dini P. Venema3, P.C.H. Hollman3, Ivonne M.C.M. Rietjens4, Jaap Keijer1
1Human and Animal Physiology, Wageningen University, Wageningen, The Netherlands
2Laboratory of Biochemistry, Wageningen University, Wageningen, The Netherlands
3RIKILT – Wageningen UR, Wageningen, The Netherlands
4Division of Toxicology, Wageningen University, Wageningen, The Netherlands

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Benavente-Garcia O, Castillo J (2008) Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity. J Agric Food Chem 56:6185–6205. doi: 10.1021/jf8006568

Boden G (2008) Obesity and free fatty acids. Endocrinol Metab Clin North Am 37:635–646

Bohn T (2014) Dietary factors affecting polyphenol bioavailability. Nutr Rev 72:429–452. doi: 10.1111/nure.12114

Chong MF, Macdonald R, Lovegrove JA (2010) Fruit polyphenols and CVD risk: a review of human intervention studies. Br J Nutr 104(Suppl 3):S28–S39. doi: 10.1017/S0007114510003922

de Boer VC, van Schothorst EM, Dihal AA, van der Woude H, Arts IC, Rietjens IM, Hollman PC, Keijer J (2006) Chronic quercetin exposure affects fatty acid catabolism in rat lung. Cell Mol Life Sci 63:2847–2858. doi: 10.1007/s00018-006-6316-z

Estruch R, Ros E, Salas-Salvado J, Covas MI, Corella D, Aros F, Gomez-Gracia E, Ruiz-Gutierrez V, Fiol M, Lapetra J, Lamuela-Raventos RM, Serra-Majem L, Pinto X, Basora J, Munoz MA, Sorli JV, Martinez JA, Martinez-Gonzalez MA, Investigators PS (2013) Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 368:1279–1290. doi: 10.1056/NEJMoa1200303

Harchaoui KE, Visser ME, Kastelein JJ, Stroes ES, Dallinga-Thie GM (2009) Triglycerides and cardiovascular risk. Curr Cardiol Rev 5:216–222. doi: 10.2174/157340309788970315

Henagan TM, Lenard NR, Gettys TW, Stewart LK (2014) Dietary quercetin supplementation in mice increases skeletal muscle PGC1alpha expression, improves mitochondrial function and attenuates insulin resistance in a time-specific manner. PLoS One 9:e89365. doi: 10.1371/journal.pone.0089365

Hoek-van den Hil EF, Beekmann K, Keijer J, Hollman PCH, Rietjens IMCM, van Schothorst EM (2012) Interference of flavonoids with enzymatic assays for the determination of free fatty acid and triglyceride levels. Anal Bioanal Chem 402:1389–1392. doi: 10.1007/s00216-011-5563-5

Hoek-van den Hil EF, Keijer J, Bunschoten A, Vervoort JJ, Stankova B, Bekkenkamp M, Herreman L, Venema D, Hollman PC, Tvrzicka E, Rietjens IM, van Schothorst EM (2013) Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice. PLoS One 8:e51588. doi: 10.1371/journal.pone.0051588

Hoek-van den Hil EF, van Schothorst EM, van der Stelt I, Swarts HJM, Venema D, Sailer M, Vervoort JJM, Hollman PCH, Rietjens IMCM, Keijer J (2014) Quercetin decreases high-fat diet induced body weight gain and accumulation of hepatic and circulating lipids in mice. Genes Nutr 9:418. doi: 10.1007/s12263-014-0418-2

Hoevenaars FP, van Schothorst EM, Horakova O, Voigt A, Rossmeisl M, Pico C, Caimari A, Kopecky J, Klaus S, Keijer J (2012) BIOCLAIMS standard diet (BIOsd): a reference diet for nutritional physiology. Genes Nutr 7:399–404. doi: 10.1007/s12263-011-0262-6

Hoevenaars FP, Keijer J, Swarts HJ, Snaas-Alders S, Bekkenkamp-Grovenstein M, van Schothorst EM (2013) Effects of dietary history on energy metabolism and physiological parameters in C57BL/6J mice. Exp Physiol 98:1053–1062. doi: 10.1113/expphysiol.2012.069518

Hoevenaars FP, Keijer J, Herreman L, Palm I, Hegeman MA, Swarts HJ, van Schothorst EM (2014) Adipose tissue metabolism and inflammation are differently affected by weight loss in obese mice due to either a high-fat diet restriction or change to a low-fat diet. Genes Nutr 9:391. doi: 10.1007/s12263-014-0391-9

Hollman PC (1997) Bioavailability of flavonoids. Eur J Clin Nutr 51(Suppl 1):S66–S69

Honkakoski P, Zelko I, Sueyoshi T, Negishi M (1998) The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene. Mol Cell Biol 18:5652–5658

Hooper L, Kroon PA, Rimm EB, Cohn JS, Harvey I, Le Cornu KA, Ryder JJ, Hall WL, Cassidy A (2008) Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials. Am J Clin Nutr 88:38–50

Janssen K, Mensink RP, Cox FJ, Harryvan JL, Hovenier R, Hollman PC, Katan MB (1998) Effects of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: results from an in vitro and a dietary supplement study. Am J Clin Nutr 67:255–262

Jung CH, Cho I, Ahn J, Jeon TI, Ha TY (2013) Quercetin reduces high-fat diet-induced fat accumulation in the liver by regulating lipid metabolism genes. Phytother Res PTR 27:139–143. doi: 10.1002/ptr.4687

Kim A, Chiu A, Barone MK, Avino D, Wang F, Coleman CI, Phung OJ (2011) Green tea catechins decrease total and low-density lipoprotein cholesterol: a systematic review and meta-analysis. J Am Diet Assoc 111:1720–1729. doi: 10.1016/j.jada.2011.08.009

Manach C, Scalbert A, Morand C, Remesy C, Jimenez L (2004) Polyphenols: food sources and bioavailability. Am J Clin Nutr 79:727–747

Manach C, Williamson G, Morand C, Scalbert A, Remesy C (2005) Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81:230S–242S

Massaro M, Scoditti E, Carluccio MA, De Caterina R (2010) Nutraceuticals and prevention of atherosclerosis: focus on omega-3 polyunsaturated fatty acids and mediterranean diet polyphenols. Cardiovasc Ther 28:e13–e19. doi: 10.1111/j.1755-5922.2010.00211.x

Mclean JA, Tobin G (1987) Animal and human calorimetry, 1st edn. Cambridge University Press, Cambridge

Murano I, Barbatelli G, Parisani V, Latini C, Muzzonigro G, Castellucci M, Cinti S (2008) Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice. J Lipid Res 49:1562–1568. doi: 10.1194/jlr.M800019-JLR200

Perez-Vizcaino F, Duarte J (2010) Flavonols and cardiovascular disease. Mol Aspects Med 31:478–494. doi: 10.1016/j.mam.2010.09.002

Peronnet F, Massicotte D (1991) Table of nonprotein respiratory quotient—an update. Can J Sport Sci 16:23–29

Peterson JJ, Dwyer JT, Jacques PF, McCullough ML (2012) Associations between flavonoids and cardiovascular disease incidence or mortality in European and US populations. Nutr Rev 70:491–508. doi: 10.1111/j.1753-4887.2012.00508.x

Phung OJ, Baker WL, Matthews LJ, Lanosa M, Thorne A, Coleman CI (2010) Effect of green tea catechins with or without caffeine on anthropometric measures: a systematic review and meta-analysis. Am J Clin Nutr 91:73–81. doi: 10.3945/ajcn.2009.28157

Qin Y, Xia M, Ma J, Hao Y, Liu J, Mou H, Cao L, Ling W (2009) Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects. Am J Clin Nutr 90:485–492. doi: 10.3945/ajcn.2009.27814

Scorletti E, Calder PC, Byrne CD (2011) Non-alcoholic fatty liver disease and cardiovascular risk: metabolic aspects and novel treatments. Endocrine 40:332–343. doi: 10.1007/s12020-011-9530-x

Slob W (2002) Dose-response modeling of continuous endpoints. Toxicol Sci 66:298–312

Spencer JP (2009) Flavonoids and brain health: multiple effects underpinned by common mechanisms. Genes Nutr 4:243–250. doi: 10.1007/s12263-009-0136-3

Srovnalova A, Svecarova M, Zapletalova MK, Anzenbacher P, Bachleda P, Anzenbacherova E, Dvorak Z (2014) Effects of anthocyanidins and anthocyanins on the expression and catalytic activities of CYP2A6, CYP2B6, CYP2C9, and CYP3A4 in primary human hepatocytes and human liver microsomes. J Agric Food Chem 62:789–797. doi: 10.1021/jf404643w

Stewart LK, Soileau JL, Ribnicky D, Wang ZQ, Raskin I, Poulev A, Majewski M, Cefalu WT, Gettys TW (2008) Quercetin transiently increases energy expenditure but persistently decreases circulating markers of inflammation in C57BL/6J mice fed a high-fat diet. Metabolism 57:S39–S46. doi: 10.1016/j.metabol.2008.03.003

Sueyoshi T, Kawamoto T, Zelko I, Honkakoski P, Negishi M (1999) The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene. J Biol Chem 274:6043–6046. doi: 10.1074/jbc.274.10.6043