Direct chemical bond of bioactive glass‐ceramic materials to bone and muscle
Tóm tắt
The objective of this research is to achieve direct chemical bonding of structurally strong implant materials with hard and soft tissues. This objective has been achieved through the development of a series of surface‐active bioglasses and bioglass‐ceramics. A controlled release of Ca, P, and Na ions from the surface of the materials produces an alkaline pH and nutrient constituents at a time when the body can incorporate the ions into newly formed tissues. Optical and electron microscopy of in‐vivo implants in rat femurs and muscles show the development of stable chemically bonded physiological interfaces after 6 weeks. Microstructure and crystallinity of the materials do not influence the bonding achieved. Mechanical measurements of the bond strength in bone show that the bone fractures before the interface does. In‐vitro studies of protein epitaxy, hydroxyapatite crystallization, and solubility kinetics correlate with the proposed interfacial bonding theory.
Từ khóa
Tài liệu tham khảo
Hench L. L., Biomaterials, Medical Devices and Artificial Organs
Housefield L. G. andHench L. L. submitted toBull. Amer. Ceram. Soc.
Hench L. L. Clark A. E. McVay J. andPaschall H. A. “A Biocompatible Stainless Steel Enamel ” to be published.
Clark A. E. andHench L. L. “Solubility Behavior of Phosphate Containing Glass‐Ceramics ” Report #2 Contract DADA 17‐70‐C‐0001 Engineering and Industrial Experiment Station University of Florida Gainesville Florida.
Piotrowski G. del Valle R. andMiller B. D. “The Mechanical Strength of a Bone‐Ceramic Bond ” Report #2 Contract DADA 17‐70‐C‐0001 Engineering and Industrial Experiment Station University of Florida Gainesville Florida.
Piotrowski G. andWilcox G. A. J. Biomechanics (1971).
Hench L. L. “Factors in Protein‐Mineral Epitaxy ” National Research Council Proceedings from a Workshop on Urolithiasis Mayo Clinic August 26–27 1971.