Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial
Tài liệu tham khảo
Guan, 2020, Clinical characteristics of coronavirus disease 2019 in China, N Engl J Med, 382, 1708, 10.1056/NEJMoa2002032
Torres Acosta, 2020, Pathogenesis of COVID-19-induced ARDS: implications for an ageing population, Eur Respir J, 56, 10.1183/13993003.02049-2020
Leisman, 2020, Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes, Lancet Respir Med, 8, 1233, 10.1016/S2213-2600(20)30404-5
Sinha, 2022, Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19, Nat Med, 28, 201, 10.1038/s41591-021-01576-3
Ackermann, 2021, Patients with COVID-19: in the dark-NETs of neutrophils, Cell Death Differ, 28, 3125, 10.1038/s41418-021-00805-z
Schurink, 2020, Viral presence and immunopathology in patients with lethal COVID-19: a prospective autopsy cohort study, Lancet Microbe, 1, e290, 10.1016/S2666-5247(20)30144-0
Seren, 2021, Proteinase release from activated neutrophils in mechanically ventilated patients with non-COVID-19 and COVID-19 pneumonia, Eur Respir J, 57, 10.1183/13993003.03755-2020
Horby, 2021, Dexamethasone in hospitalized patients with COVID-19, N Engl J Med, 384, 693, 10.1056/NEJMoa2021436
Brown, 2021, Interleukin-6 receptor antagonists in critically ill patients with COVID-19, N Engl J Med, 385, 1147, 10.1056/NEJMc2108482
Chalmers, 2021, Management of hospitalised adults with coronavirus disease 2019 (COVID-19): a European Respiratory Society living guideline, Eur Respir J, 57, 10.1183/13993003.00048-2021
Palmér, 2018, Dipeptidyl peptidase 1 inhibitor AZD7986 induces a sustained, exposure-dependent reduction in neutrophil elastase activity in healthy subjects, Clin Pharmacol Ther, 104, 1155, 10.1002/cpt.1053
Chalmers, 2020, Phase 2 trial of the DPP-1 inhibitor brensocatib in bronchiectasis, N Engl J Med, 383, 2127, 10.1056/NEJMoa2021713
Veras, 2020, SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology, J Exp Med, 217, 10.1084/jem.20201129
Zuo, 2020, Neutrophil extracellular traps in COVID-19, JCI Insight, 5
McElvaney, 2020, Characterization of the inflammatory response to severe COVID-19 illness, Am J Respir Crit Care Med, 202, 812, 10.1164/rccm.202005-1583OC
Horby, 2020, Effect of hydroxychloroquine in hospitalized patients with COVID-19, N Engl J Med, 383, 2030, 10.1056/NEJMoa2022926
Veiga, 2021, Effect of tocilizumab on clinical outcomes at 15 days in patients with severe or critical coronavirus disease 2019: randomised controlled trial, BMJ, 372, n84, 10.1136/bmj.n84
2021, Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial, Lancet, 397, 1637, 10.1016/S0140-6736(21)00676-0
Gordon, 2021, Interleukin-6 receptor antagonists in critically ill patients with COVID-19—preliminary report, medRxiv
Geerdink, 2015, Neutrophils in respiratory syncytial virus infection: a target for asthma prevention, J Allergy Clin Immunol, 136, 838, 10.1016/j.jaci.2015.06.034
Akk, 2016, Neutrophil extracellular traps enhance early inflammatory response in sendai virus-induced asthma phenotype, Front Immunol, 7, 325, 10.3389/fimmu.2016.00325
Porto, 2016, Neutrophil extracellular traps in pulmonary diseases: too much of a good thing?, Front Immunol, 7, 311, 10.3389/fimmu.2016.00311
Tak, 2018, Neutrophil-mediated suppression of influenza-induced pathology requires CD11b/CD18 (MAC-1), Am J Respir Cell Mol Biol, 58, 492, 10.1165/rcmb.2017-0021OC
Domon, 2021, Proteolytic cleavage of HLA class II by human neutrophil elastase in pneumococcal pneumonia, Sci Rep, 11, 10.1038/s41598-021-82212-5
van den Berg, 2014, Mechanism of neutrophil dysfunction: neutrophil serine proteases cleave and inactivate the C5a receptor, J Immunol, 192, 1787, 10.4049/jimmunol.1301920
Perng, 2003, Neutrophil elastase stimulates human airway epithelial cells to produce PGE2 through activation of p44/42 MAPK and upregulation of cyclooxygenase-2, Am J Physiol Lung Cell Mol Physiol, 285, L925, 10.1152/ajplung.00182.2002
Apel, 2021, The cytosolic DNA sensor cGAS recognizes neutrophil extracellular traps, Sci Signal, 14, 10.1126/scisignal.aax7942
Stephenson, 2021, Single-cell multi-omics analysis of the immune response in COVID-19, Nat Med, 27, 904, 10.1038/s41591-021-01329-2
Tate, 2009, Neutrophils ameliorate lung injury and the development of severe disease during influenza infection, J Immunol, 183, 7441, 10.4049/jimmunol.0902497
Turk, 2001, Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases, EMBO J, 20, 6570, 10.1093/emboj/20.23.6570
Pham, 1999, Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo, Proc Natl Acad Sci USA, 96, 8627, 10.1073/pnas.96.15.8627
Wolters, 2001, Dipeptidyl peptidase I is essential for activation of mast cell chymases, but not tryptases, in mice, J Biol Chem, 276, 18551, 10.1074/jbc.M100223200
