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Diosmin phòng ngừa làm giảm tổn thương thận do gentamicin ở chuột bạch
Naunyn-Schmiedebergs Archiv für Pharmakologie und experimentelle Pathologie - Tập 396 - Trang 63-71 - 2022
Tóm tắt
Gentamicin là một kháng sinh aminoglycoside rất quan trọng, nhưng chỉ được sử dụng để điều trị các nhiễm trùng do vi khuẩn nặng do tính độc với thận cao ở bệnh nhân. Chúng tôi đã đánh giá tác dụng phòng ngừa của diosmin (như một thành phần tự nhiên) đối với tổn thương thận liên quan đến gentamicin ở chuột bạch. Trong nghiên cứu này, 28 con chuột Wistar đực được chia thành bốn nhóm: nhóm đối chứng, gentamicin (100 mg/kg (i.p.), hàng ngày trong 1 tuần), gentamicin cộng với diosmin (50 mg/kg, p.o., hàng ngày trong 2 tuần), và diosmin (50 mg/kg/ngày, p.o. trong 2 tuần). Sau khi kết thúc đợt điều trị, mẫu máu được thu thập để xác định nồng độ nitơ ure máu (BUN) và creatinine. Thận được sử dụng để thực hiện các xét nghiệm sinh hóa, viêm và mô học. Nồng độ creatinine, BUN, nitric oxide, malondialdehyde, yếu tố hoại tử khối u α (TNF-α) và interleukin 1 beta (IL-1β) đã tăng đáng kể. Tuy nhiên, mức glutathione và hoạt tính của catalase, glutathione peroxidase, và superoxide dismutase đã giảm trong quá trình điều trị với gentamicin. Mặt khác, nồng độ creatinine, BUN, nitric oxide, malondialdehyde, TNF-α và IL-1β đã giảm đáng kể, trong khi mức glutathione, hoạt tính của catalase và glutathione peroxidase đã tăng đáng kể nhờ sự phối hợp sử dụng với diosmin. Diosmin đã có tác động cải thiện đối với tổn thương thận liên quan đến gentamicin nhờ vào các hoạt động chống oxy hóa và chống viêm của nó.
Từ khóa
#gentamicin #diosmin #tổn thương thận #chuột Wistar #hoạt động chống oxy hóa #hoạt động chống viêmTài liệu tham khảo
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