Dimer conformation of soluble PECAM-1, an endothelial marker

Arai, 2004, Conformations of variably linked chimeric proteins evaluated by synchrotron X-ray small-angle scattering, Proteins, 57, 829, 10.1002/prot.20244 Arnold, 2006, The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling, Bioinformatics, 22, 195, 10.1093/bioinformatics/bti770 Breier, 1996, Molecular cloning and expression of murine vascular endothelial-cadherin in early stage development of cardiovascular system, Blood, 87, 630, 10.1182/blood.V87.2.630.bloodjournal872630 Brunger, 2007, Version 1.2 of the crystallography and NMR system, Nat. Protoc., 2, 2728, 10.1038/nprot.2007.406 Buckley, 1996, Identification of alpha v beta 3 as a heterotypic ligand for CD31/PECAM-1, J. Cell Sci., 109, 437, 10.1242/jcs.109.2.437 Cicmil, 2000, Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets. Evidence for the involvement of Src family kinases, J. Biol. Chem., 275, 27339, 10.1016/S0021-9258(19)61516-4 Cicmil, 2002, Platelet endothelial cell adhesion molecule-1 signaling inhibits the activation of human platelets, Blood, 99, 137, 10.1182/blood.V99.1.137 Dangerfield, 2002, PECAM-1 (CD31) homophilic interaction up-regulates alpha6beta1 on transmigrated neutrophils in vivo and plays a functional role in the ability of alpha6 integrins to mediate leukocyte migration through the perivascular basement membrane, J. Exp. Med., 196, 1201, 10.1084/jem.20020324 DeLisser, 1993, Platelet/endothelial cell adhesion molecule-1 (CD31)-mediated cellular aggregation involves cell surface glycosaminoglycans, J. Biol. Chem., 268, 16037, 10.1016/S0021-9258(18)82354-7 Deaglio, 1998, Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member, J. Immunol., 160, 395, 10.4049/jimmunol.160.1.395 Duncan, 1999, Genetic evidence for functional redundancy of platelet/endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions, J. Immunol., 162, 3022, 10.4049/jimmunol.162.5.3022 Falati, 2006, Platelet PECAM-1 inhibits thrombus formation in vivo, Blood, 107, 535, 10.1182/blood-2005-04-1512 Fawcett, 1995, Mapping the homotypic binding sites in CD31 and the role of CD31 adhesion in the formation of interendothelial cell contacts, J. Cell Biol., 128, 1229, 10.1083/jcb.128.6.1229 Fischer, 2010, Determination of the molecular weight of proteins in solution from a single small-angle X-ray scattering measurement on a relative scale, J. Appl. Crystallogr., 43, 101, 10.1107/S0021889809043076 Franke, 2009, DAMMIF, a program for rapid ab-initio shape determination in small-angle scattering, J. Appl. Crystallogr., 42, 342, 10.1107/S0021889809000338 Konarev, 2003, PRIMUS: a Windows PC-based system for small-angle scattering data analysis, J. Appl. Crystallogr., 36, 1277, 10.1107/S0021889803012779 Lipfert, 2007, Small-angle X-ray scattering from RNA, proteins, and protein complexes, Annu. Rev. Biophys. Biomol. Struct., 36, 307, 10.1146/annurev.biophys.36.040306.132655 Matsumura, 1997, Endothelial cell tube formation depends on cadherin 5 and CD31 interactions with filamentous actin, J. Immunol., 158, 3408, 10.4049/jimmunol.158.7.3408 Mei, 2014, Regulation of endothelial cell barrier function by antibody-driven affinity modulation of platelet endothelial cell adhesion molecule-1 (PECAM-1), J. Biol. Chem., 289, 20836, 10.1074/jbc.M114.557454 Mertens, 2010, Structural characterization of proteins and complexes using small-angle X-ray solution scattering, J. Struct. Biol., 172, 128, 10.1016/j.jsb.2010.06.012 Newton, 1997, Residues on both faces of the first immunoglobulin fold contribute to homophilic binding sites of PECAM-1/CD31, J. Biol. Chem., 272, 20555, 10.1074/jbc.272.33.20555 Newton, 1999, CD31 (PECAM-1) exists as a dimer and is heavily N-glycosylated, Biochem. Biophys. Res. Commun., 261, 283, 10.1006/bbrc.1999.1018 Newton-Nash, 1999, A new role for platelet-endothelial cell adhesion molecule-1 (CD31): inhibition of TCR-mediated signal transduction, J. Immunol., 163, 682, 10.4049/jimmunol.163.2.682 O'Brien, 2004, Makrigiannakis , H. M. DeLisser. Role of immunoreceptor tyrosine-based inhibitory motifs of PECAM-1 in PECAM-1-dependent cell migration, Am. J. Physiol. Cell Physiol., 287, C1103, 10.1152/ajpcell.00573.2003 Paddock, 2016, Structural basis for PECAM-1 homophilic binding, Blood, 127, 1052, 10.1182/blood-2015-07-660092 Patil, 2001, Platelet endothelial cell adhesion molecule-1 serves as an inhibitory receptor that modulates platelet responses to collagen, Blood, 97, 1727, 10.1182/blood.V97.6.1727 Petoukhov, 2012, New developments in the ATSAS program package for small-angle scattering data analysis, J. Appl. Crystallogr., 45, 342, 10.1107/S0021889812007662 Pettersen, 2004, UCSF Chimera–a visualization system for exploratory research and analysis, J. Comput. Chem., 25, 1605, 10.1002/jcc.20084 Pettersen, 2004, UCSF Chimera—a visualization system for exploratory research and analysis, J. Comput. Chem., 25, 1605, 10.1002/jcc.20084 Piali, 1993, Murine platelet endothelial cell adhesion molecule (PECAM-1)/CD31 modulates beta 2 integrins on lymphokine-activated killer cells, Eur. J. Immunol., 23, 2464, 10.1002/eji.1830231013 Sachs, 2007, The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31), J. Biol. Chem., 282, 23603, 10.1074/jbc.M701120200 Schenkel, 2004, Platelet endothelial cell adhesion molecule deficiency or blockade significantly reduces leukocyte emigration in a majority of mouse strains, J. Immunol., 173, 6403, 10.4049/jimmunol.173.10.6403 Sun, 1998, Cell surface glycosaminoglycans do not serve as ligands for PECAM-1: PECAM-1 is not a heparin-binding protein, J. Biol. Chem., 273, 11483, 10.1074/jbc.273.19.11483 Svergun, 2010, Small-angle X-ray and neutron scattering as a tool for structural systems biology, Biol. Chem., 391, 737, 10.1515/bc.2010.093 Volkov, 2003, Uniqueness of ab initio shape determination in small-angle scattering, J. Appl. Crystallogr., 36, 860, 10.1107/S0021889803000268 Watt, 1993, The heparin binding PECAM-1 adhesion molecule is expressed by CD34+ hematopoietic precursor cells with early myeloid and B-lymphoid cell phenotypes, Blood, 82, 2649, 10.1182/blood.V82.9.2649.2649 Wong, 2000, PECAM-1/CD31 trans-homophilic binding at the intercellular junctions is independent of its cytoplasmic domain; evidence for heterophilic interaction with integrin alphavbeta3 in Cis, Mol. Biol. Cell, 11, 3109, 10.1091/mbc.11.9.3109