Digoxin net secretory transport in bronchial epithelial cell layers is not exclusively mediated by P-glycoprotein/MDR1

Victoria Hutter1, David Y.S. Chau2, Constanze Hilgendorf3, Alan Brown4, Anne Cooper5, Vanessa Zann5, David I. Pritchard4, Cynthia Bosquillon1
1Division of Drug Delivery and Tissue Engineering, School of Pharmacy, University of Nottingham, UK
2Allergy Research Group, School of Molecular Medical Sciences, University of Nottingham, UK
3AstraZeneca R&D, Mölndal, Sweden
4Immune Modulation Group, Division of Molecular and Cellular Science, School of Pharmacy, University of Nottingham, UK
5AstraZeneca R&D Charnwood, Loughborough, UK

Tài liệu tham khảo

Bosquillon, 2010, Drug transporters in the lung – do they play a role in the biopharmaceutics of inhaled drugs?, J. Pharm. Sci., 99, 2240, 10.1002/jps.21995 Forbes, 2011, Challenges in inhaled product development and opportunities for open innovation, Adv. Drug. Deliv. Rev., 63, 69, 10.1016/j.addr.2010.11.004 Sporty, 2008, In vitro cell culture models for the assessment of pulmonary drug disposition, Expert. Opin. Drug. Metab. Toxicol., 4, 333, 10.1517/17425255.4.4.333 Forbes, 2005, Human respiratory epithelial cell culture for drug delivery applications, Eur. J. Pharm. Biopharm., 60, 193, 10.1016/j.ejpb.2005.02.010 Grainger, 2006, Culture of Calu-3 cells at the air interface provides a representative model of the airway epithelial barrier, Pharm. Res., 23, 1482, 10.1007/s11095-006-0255-0 Lin, 2007, Air–liquid interface (ALI) culture of human bronchial epithelial cell monolayers as an in vitro model for airway drug transport studies, J. Pharm. Sci., 96, 341, 10.1002/jps.20803 Mukherjee, 2012, Evaluation of air-interfaced Calu-3 cell layers for investigation of inhaled drug interactions with organic cation transporters in vitro, Int. J. Pharm., 426, 7, 10.1016/j.ijpharm.2011.12.036 Mamlouk, 2013, Salbutamol sulfate absorption across Calu-3 bronchial epithelia cell monolayer is inhibited in the presence of common anionic NSAIDs, J. Asthma, 50, 334, 10.3109/02770903.2013.773518 H.X. Ong, D. Traini, M. Bebawy, P.M. Young, Ciprofloxacin is actively transported across bronchial lung epithelial using a Calu-3 air-interface cell model, Antimicrob. Agents Chemother. (2013) (March 18) (Epub ahead of print). Glaeser, 2011, Importance of P-glycoprotein for drug–drug interactions, Handb. Exp. Pharmacol., 201, 285, 10.1007/978-3-642-14541-4_7 Urquhart, 2009, Blood–brain barrier transporters and response to CNS-active drugs, Eur. J. Clin. Pharmacol., 65, 1063, 10.1007/s00228-009-0714-8 Bleasby, 2006, Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: a resource for investigations into drug disposition, Xenobiotica, 36, 963, 10.1080/00498250600861751 Madlova, 2009, In-vitro respiratory drug absorption models possess nominal functional P-glycoprotein activity, J. Pharm. Pharmacol., 61, 293, 10.1211/jpp.61.03.0003 Haghi, 2010, Time- and passage-dependent characteristics of a Calu-3 respiratory epithelial cell model, Drug. Dev. Ind. Pharm., 36, 1207, 10.3109/03639041003695113 Rautio, 2006, In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates, Drug Metab. Dispos., 34, 786, 10.1124/dmd.105.008615 Huang, 2007, Drug interaction studies: study design, data analysis, and implications for dosing and labeling, Clin. Pharmacol. Ther., 81, 298, 10.1038/sj.clpt.6100054 Manford, 2005, Drug permeability in 16HBE14o-airway cell layers correlates with absorption from the isolated perfused rat lung, Eur. J. Pharm. Sci., 26, 414, 10.1016/j.ejps.2005.07.010 Smith, 2000, MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping, J. Biol. Chem., 275, 23530, 10.1074/jbc.M909002199 Kullak-Ublick, 2001, Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver, Gastroenterology, 120, 525, 10.1053/gast.2001.21176 Mikkaichi, 2004, Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney, Proc. Natl. Acad. Sci. USA, 101, 3569, 10.1073/pnas.0304987101 Yamaguchi, 2010, Transport of estrone 3-sulfate mediated by organic anion transporter OATP4C1: estrone 3-sulfate binds to the different recognition site for digoxin in OATP4C1, Drug Metab. Pharmacokinet., 25, 314, 10.2133/dmpk.25.314 Kimoto, 2011, Characterization of digoxin uptake in sandwich-cultured human hepatocytes, Drug Metab. Dispos., 39, 47, 10.1124/dmd.110.034298 Taub, 2011, Digoxin is not a substrate for organic anion transporting polypeptide transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but is a substrate for a sodium dependent transporter expressed in HEK293 Cells, Drug Metab. Dispos., 39, 2093, 10.1124/dmd.111.040816 Wang, 2008, Application and limitation of inhibitors in drug-transporter interactions studies, Int. J. Pharm., 356, 12, 10.1016/j.ijpharm.2007.12.024 Mease, 2012, Differential selectivity of efflux transporter inhibitors in Caco-2 and MDCK-MDR1 monolayers: a strategy to assess the interaction of a new chemical entity with P-gp, BCRP, and MRP2, J. Pharm. Sci., 101, 1888, 10.1002/jps.23069 Hilgendorf, 2007, Expression of thrity-six drug transporter genes in human intestine, liver, kidney and organotypic cell lines, Drug Metab. Dispos., 35, 1333, 10.1124/dmd.107.014902 Mechetner, 1997, P-glycoprotein function involves conformational transitions detectable by differential immunoreactivity, Proc. Natl. Acad. Sci. USA, 94, 12908, 10.1073/pnas.94.24.12908 Endter, 2009, RT-PCR analysis of ABC, SLC and SLCO drug transporters in human lung epithelial cell models, J. Pharm. Pharmacol., 61, 583, 10.1211/jpp.61.05.0006 Kuteykin-Teplyakov, 2010, Differences in the expression of endogenous efflux transporters in MDR1-transfected versus wildtype cell lines affect P-glycoprotein mediated drug transport, Br. J. Pharmacol., 160, 1453, 10.1111/j.1476-5381.2010.00801.x Park, 2003, Analysis of P-glycoprotein-mediated membrane transport in human peripheral blood lymphocytes using the UIC2 shift assay, Cytometry A, 53, 67, 10.1002/cyto.a.10039 Mechetner, 2007, Detection of the MDR1 P-glycoprotein expression and function, Methods Mol. Biol., 378, 175, 10.1007/978-1-59745-323-3_13 Zhou, 2008, Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development, Curr. Med. Chem., 15, 1981, 10.2174/092986708785132870 Lowes, 2003, Evidence for a non-MDR1 component in digoxin secretion by human intestinal Caco-2 epithelial layers, Eur. J. Pharmacol., 458, 49, 10.1016/S0014-2999(02)02764-4 Hamilton, 2001, P-glycoprotein efflux pump expression and activity in Calu-3 cells, J. Pharm. Sci., 90, 647, 10.1002/1520-6017(200105)90:5<647::AID-JPS1021>3.0.CO;2-G Scheffer, 2002, Multidrug resistance related molecules in human and murine lung, J. Clin. Pathol., 55, 332, 10.1136/jcp.55.5.332 Gribar, 2000, Functional characterization of glycosylation-deficient human P-glycoprotein using a vaccinia virus expression system, J. Membr. Biol., 173, 203, 10.1007/s002320001020 Sereš, 2011, Tunicamycin depresses p-glycoprotein glycosylation without an effect on its membrane localization and drug efflux activity in l1210 cells, Int. J. Mol. Sci., 12, 7772, 10.3390/ijms12117772 Draheim, 2010, N-glycosylation of ABC transporters is associated with functional activity in sandwich-cultured rat hepatocytes, Eur. J. Pharm. Sci., 41, 201, 10.1016/j.ejps.2010.06.005 Molnár, 2009, Interaction of tomato lectin with ABC transporter in cancer cells: glycosylation confers functional conformation of P-gp, Acta Histochem., 111, 329, 10.1016/j.acthis.2008.11.010 Kramer, 1995, Inhibition of N-linked glycosylation of P-glycoprotein by tunicamycin results in a reduced multidrug resistance phenotype, Br. J. Cancer, 71, 670, 10.1038/bjc.1995.133 Goda, 2007, Complete inhibition of P-glycoprotein by simultaneous treatment with a distinct class of modulators and the UIC2 monoclonal antibody, J. Pharmacol. Exp. Ther., 320, 81, 10.1124/jpet.106.110155 Letschert, 2005, Vectorial transport of the peptide CCK-8 by double-transfected MDCKII cells stably expressing the organic anion transporter OATP1B3 (OATP8) and the export pump ABCC2, J. Pharmacol. Exp. Therapy, 313, 356, 10.1124/jpet.104.081224 Letschert, 2006, Molecular characterization and inhibition of amanitin uptake into human hepatocytes, Toxicol. Sci., 91, 140, 10.1093/toxsci/kfj141 Childs, 1998, Taxol resistance mediated by transfection of the liver-specific sister gene of P-glycoprotein, Cancer Res., 58, 4160 Böhme, 1993, Differential inhibition by cyclosporins of primary-active ATP-dependent transporters in the hepatocyte canalicular membrane, FEBS Lett., 333, 193, 10.1016/0014-5793(93)80403-H Bourasset, 2003, Evidence for an active transport of morphine-6-beta-d-glucuronide but not P-glycoprotein-mediated at the blood-brain barrier, J. Neurochem., 86, 1564, 10.1046/j.1471-4159.2003.01990.x Acharya, 2008, Kinetic identification of membrane transporters that assist P-glycoprotein-mediated transport of digoxin and loperamide through a confluent monolayer of MDCKII-hMDR1 cells, Drug Metab. Dispos., 36, 452, 10.1124/dmd.107.017301 Peters, 2011, Oral absorption of clarithromycin is nearly abolished by chronic comedication of rifampicin in foals, Drug Metab. Dispos., 39, 1643, 10.1124/dmd.111.039206