Digital spatial profiling to predict recurrence in grade 3 stage I lung adenocarcinoma

Siegel, 2022, Cancer statistics, 2022, CA Cancer J Clin, 72, 7, 10.3322/caac.21708 Aberle, 2011, Reduced lung-cancer mortality with low-dose computed tomographic screening, N Engl J Med, 365, 395, 10.1056/NEJMoa1102873 Goldstraw, 2016, The IASLC lung cancer staging project: proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung cancer, J Thorac Oncol, 11, 39, 10.1016/j.jtho.2015.09.009 Felip, 2021, Adjuvant atezolizumab after adjuvant chemotherapy in resected stage IB-IIIA non-small-cell lung cancer (IMpower010): a randomised, multicentre, open-label, phase 3 trial, Lancet, 398, 1344, 10.1016/S0140-6736(21)02098-5 Forde, 2022, Neoadjuvant nivolumab plus chemotherapy in resectable lung cancer, N Engl J Med, 386, 1973, 10.1056/NEJMoa2202170 Herbst, 2023, Adjuvant osimertinib for resected EGFR-mutated stage IB-IIIA non-small-cell lung cancer: updated results from the phase III randomized ADAURA trial, J Clin Oncol, 41, 1830, 10.1200/JCO.22.02186 Ettinger, 2023, NCCN guidelines(R) insights: non-small cell lung cancer, version 2.2023, J Natl Compr Canc Netw, 21, 340, 10.6004/jnccn.2023.0020 Moreira, 2020, A grading system for invasive pulmonary adenocarcinoma: a proposal from the International Association for the Study of Lung Cancer Pathology Committee, J Thorac Oncol, 15, 1599, 10.1016/j.jtho.2020.06.001 Luca, 2023, The prognostic value of histopathology in invasive lung adenocarcinoma: a comparative review of the main proposed grading systems, Expert Rev Anticancer Ther, 23, 265, 10.1080/14737140.2023.2179990 Yanagawa, 2023, The new IASLC grading system for invasive non-mucinous lung adenocarcinoma is a more useful indicator of patient survival compared with previous grading systems, J Surg Oncol, 127, 174, 10.1002/jso.27091 Merritt, 2020, Multiplex digital spatial profiling of proteins and RNA in fixed tissue, Nat Biotechnol, 38, 586, 10.1038/s41587-020-0472-9 Zimmerman, 2022, Spatially resolved whole transcriptome profiling in human and mouse tissue using digital spatial profiling, Genome Res, 32, 1892 Levy, 2023, Identification of spatial proteomic signatures of colon tumor metastasis: a digital spatial profiling approach, Am J Pathol, 6, 778, 10.1016/j.ajpath.2023.02.020 Kulasinghe, 2020, Highly multiplexed digital spatial profiling of the tumor microenvironment of head and neck squamous cell carcinoma patients, Front Oncol, 10 Kulasinghe, 2021, Spatial profiling identifies prognostic features of response to adjuvant therapy in triple negative breast cancer (TNBC), Front Oncol, 11 Toki, 2019, High-plex predictive marker discovery for melanoma immunotherapy-treated patients using digital spatial profiling, Clin Cancer Res, 25, 5503, 10.1158/1078-0432.CCR-19-0104 Romero, 2017, Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis, Nat Med, 23, 1362, 10.1038/nm.4407 Lanczky, 2021, Web-based survival analysis tool tailored for medical research (KMplot): development and implementation, J Med Internet Res, 23, 10.2196/27633 Song, 2023, Spatial multi-omics revealed the impact of tumor ecosystem heterogeneity on immunotherapy efficacy in patients with advanced non-small cell lung cancer treated with bispecific antibody, J Immunother Cancer, 11, 10.1136/jitc-2022-006234 Larroquette, 2022, Spatial transcriptomics of macrophage infiltration in non-small cell lung cancer reveals determinants of sensitivity and resistance to anti-PD1/PD-L1 antibodies, J Immunother Cancer, 10, 10.1136/jitc-2021-003890 Monkman, 2020, High-plex and high-throughput digital spatial profiling of Non-small-cell lung cancer (NSCLC), Cancers (Basel), 12, 3551, 10.3390/cancers12123551 Zugazagoitia, 2020, Biomarkers associated with beneficial PD-1 checkpoint blockade in Non-small cell lung cancer (NSCLC) identified using high-plex digital spatial profiling, Clin Cancer Res, 26, 4360, 10.1158/1078-0432.CCR-20-0175 Hernandez, 2023 He, 2004, Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray, Hum Pathol, 35, 1196, 10.1016/j.humpath.2004.06.014 Melling, 2017, High-level gamma-glutamyl-hydrolase (GGH) expression is linked to poor prognosis in ERG negative prostate cancer, Int J Mol Sci, 18, 286, 10.3390/ijms18020286 Shubbar, 2013, High levels of gamma-glutamyl hydrolase (GGH) are associated with poor prognosis and unfavorable clinical outcomes in invasive breast cancer, BMC Cancer, 13, 47, 10.1186/1471-2407-13-47 Yoshida, 2016, Molecular factors associated with pemetrexed sensitivity according to histological type in non-small cell lung cancer, Anticancer Res, 36, 6319, 10.21873/anticanres.11228 Kurihara-Shimomura, 2020, Peroxidan plays a tumor-promoting role in oral squamous cell carcinoma, Int J Mol Sci, 21, 5416, 10.3390/ijms21155416 Li, 2020, Lamin B1 overexpresses in lung adenocarcinoma and promotes proliferation in lung cancer cells via AKT pathway, OncoTargets Ther, 13, 3129, 10.2147/OTT.S229997 Tang, 2021, Silencing LMNB1 contributes to the suppression of lung adenocarcinoma development, Cancer Manag Res, 13, 2633, 10.2147/CMAR.S275874 Wang, 2021, The relationship between UBE2C and AGGF1 overexpression and tumor angiogenesis in Non-small cell lung cancer, Cancer Manag Res, 13, 5919, 10.2147/CMAR.S320393 Ye, 2018, Expression of TARBP1 protein in human Non-small-cell lung cancer and its prognostic significance, Oncol Lett, 15, 7182 Gyorffy, 2013, Online survival analysis software to assess the prognostic value of biomarkers using transcriptomic data in Non-small-cell lung cancer, PLoS One, 8, 10.1371/journal.pone.0082241 Sheffels, 2018, Oncogenic RAS isoforms show a hierarchical requirement for the guanine nucleotide exchange factor SOS2 to mediate cell transformation, Sci Signal, 11, 10.1126/scisignal.aar8371 Huncharek, 1999, K-rad oncogene mutation as a prognostic marker in non-small cell lung cancer: a combined analysis of 881 cases, Carcinogenesis, 20, 1507, 10.1093/carcin/20.8.1507 Madden, 2019, The role of the unfolded protein response in cancer progression: from oncogenesis to chemoresistance, Biol Cell, 111, 1, 10.1111/boc.201800050 Oakes, 2020, Endoplasmic reticulum stress signaling in cancer cells, Am J Pathol, 190, 934, 10.1016/j.ajpath.2020.01.010