Diffusion-weighted magnetic resonance imaging for predicting and detecting the response of ocular melanoma to proton beam therapy: initial results

La radiologia medica - Tập 120 - Trang 526-535 - 2015
Pietro Valerio Foti1, Renato Farina1, Maria Coronella1, Stefano Palmucci1, Angelo Montana1, Alessandra Sigona1, Michele Reibaldi2, Antonio Longo2, Andrea Russo2, Teresio Avitabile2, Rosario Caltabiano3, Lidia Puzzo3, Marco Ragusa4, Cesare Mariotti5, Pietro Milone1, Giovanni Carlo Ettorre1
1Dipartimento Specialità Medico-Chirurgiche, Sezione di Scienze Radiologiche, Università di Catania, Catania, Italy
2Dipartimento di Oftalmologia, Università di Catania, Catania, Italy
3Dipartimento G.F. Ingrassia, Sezione di Anatomia Patologica, Università di Catania, Catania, Italy
4Dipartimento G.F. Ingrassia, Unità di BioMedicina Molecolare Genomica e dei Sistemi Complessi, Genetica, Biologia Computazionale, Università di Catania, Catania, Italy
5Dipartimento di Oftalmologia, Università Politecnica delle Marche, Ancona, Italy

Tóm tắt

The aim of this study was to investigate the utility of diffusion-weighted magnetic resonance (MR) imaging for prediction and early detection of response to proton beam therapy in ocular melanoma. Ten ocular melanoma patients treated with proton beam therapy were enrolled in the study. All patients underwent conventional MR imaging and diffusion-weighted imaging (DWI) before the start of therapy, and after 1, 3 and 6 months of therapy. Tumour volumes and apparent diffusion coefficient (ADC) values of ocular lesions were measured at each examination. Tumour volumes and mean ADC measurements of the four examination series were compared; correlation of ADC values and tumour regression was investigated. Mean ADC value of ocular melanomas significantly increased as early as 3 months after therapy; tumour volume significantly decreased as early as 6 months after therapy. The ADC values of ocular melanomas before therapy significantly correlated with tumour regression. DWI may provide an early surrogate biomarker for prediction and early detection of tumour response to eye-preserving therapies in ocular melanoma.

Tài liệu tham khảo

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