Hình ảnh tensor khuếch tán tương quan với bệnh tế bào trong mô hình chuột nhiễm hydrocephalus ở trẻ sơ sinh

Cerebrospinal Fluid Research - Tập 7 Số 1 - 2010
Weihong Yuan1, Kelley E Deren2, James P. McAllister2, Scott K. Holland1, Diana M. Lindquist3, Alessandro Cancelliere4, Matthew S. Mason2, A. Duke Shereen3, Dean A. Hertzler4, Mekibib Altaye5, Francesco T. Mangano4
1Department of Radiology, Pediatric Neuroimaging Research Consortium, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, MLC 5033, 3333 Burnet Ave., Cincinnati, OH, 45229, USA
2Department of Neurosurgery, Division of Pediatric Neurosurgery, Primary Children's Medical Center and the University of Utah, N. Medical Drive East, Salt Lake City, UT, 84132, USA
3Department of Radiology, Imaging Research Center, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, MLC 5033, 3333 Burnet Ave., Cincinnati, OH, 45229, USA
4Division of Pediatric Neurosurgery, University of Cincinnati, Cincinnati Children's Hospital Medical Center MLC 2016, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA
5Department of Biostatistics & Epidemiology, Cincinnati Children's Hospital Medical Center, MLC 5041, 3333 Burnet Ave., Cincinnati, OH, 45229, USA

Tóm tắt

Tóm tắt Điều kiện nền tảng Hình ảnh tensor khuếch tán (DTI) là một kỹ thuật MRI không xâm lấn được sử dụng để định lượng các bất thường của hệ thần kinh trung ương (CNS) trong nhiều tình trạng bệnh lý khác nhau. Nghiên cứu này được thiết kế để định lượng đặc tính khuếch tán bất đối xứng trong não của chuột con mắc bệnh hydrocephalus (HCP) và điều tra mối liên quan giữa các phép đo DTI và bệnh lý tế bào. Phương pháp Dữ liệu DTI được thu thập từ ngày thứ 7 sau sinh (P7) đến P12 ở 12 con chuột mắc HCP được gây ra vào P2 và 15 con chuột điều khiển đồng tuổi. Các động vật được euthanasia vào P11 hoặc P22/P23 và não được xử lý bằng kỹ thuật nhuộm miễn dịch hóa học cho protein axit fibrillary glial (GFAP), phân tử gắn ion canxi (Iba-1), và nhuộm Luxol Fast Blue (LFB) để đánh giá mức độ tế bào sao, phản ứng của vi tâm bào và mức độ myelination tương ứng.

Từ khóa


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Cerebrospinal Fluid Research

Tập 7 Số 1

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