Differential responses of human tumor cell lines to anti-p185HER2 monoclonal antibodies

Gail D. Lewis1, Irene S. Figari2, Brian M. Fendly2, Wai-Lee Wong2, P Carter2, Cornelia M. Gorman2, H M Shepard2
1Genentech Inc.,** South San Francisco, CA 94080
2Department of Cell Analysis, Genentech Inc., South San Francisco, USA

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Aasland R, Lillehaug JR, Hale R, et al (1988) Expression of oncogenes in thyroid tumors: coexpression of c-erbB2/neu and c-erbB. Br J Cancer 57: 358?363

Akiyama T, Sudo C, Ogawara H, et al (1986) The product of the human c-erbB-2 gene: a 185-kilodalton glycoprotein with tyrosine kinase activity. Science 232: 1644?1646

Benz CC, Scott GK, Sarup JC, et al (1991) Tamoxifen resistance associated with p185HER2 overexpression in human breast cancer cells transfected with HER2/neu. Proc Am Assoc Cancer Res 32: 211

Berchuck A, Kamel A, Whitaker R, et al (1990) Overexpression of HER-2/neu is associated with poor survival in advanced epithelial ovarian cancer. Cancer Res 50: 4087?4091

Berchuck A, Rodriguez G, Kinney RB, et al (1991) Overexpression of HER-2/neu in endometrial cancer is associated with advanced stage discase. Am J Obstet, Gynecol 164: 15?21

Berger MS, Locher GW, Saurer S, et al (1988) Correlation of c-erbB-2 gene amplification and protein expression in human breast carcinoma with nodal status and nuclear grading. Cancer Res 48: 1238?1243

Bonilla M, Ramirez M, Lopez-Cueto J, et al (1988) In vivo amplification and rearrangement of c-myc oncogene in human breast tumors. JNCI 80: 665?671

Borst MP, Baker VV, Dixon D, et al (1990) Oncogene alterations in endometrial cancer. Gynecol Oncol 38: 364?366

Brodeur GM, Seeger RC, Schwab M, et al (1984) Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science 224: 1121?1124

Brüderlein S, van der Bosch K, Schlag P, et al (1990) Cytogenetics and DNA amplification in colorectal cancers. Genes Chromosomes Cancer 2: 63?70

Carter P, Presta L, Gorman CM, et al (1993) Humanization of an anti-p185HER2 antibody for human cancer therapy. Proc Natl Acad Sci USA (in press)

Coussens L, Yang-Feng TL, Liao Y-C, et al (1985) Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location withneu oncogene. Science 230: 1132?1139

Drebin JA, Link VC, Stern DF, et al (1985) Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies. Cell 41: 695?706

Drebin JA, Link VC, Greene MI (1988) Monoclonal antibodies specific for theneu oncogene product directly mediate anti-tumor effects in vivo. Oncogene 2: 387?394

Drebin JA, Link VC, Greene MI (1988) Monoclonal antibodies reactive with distinct domains of theneu oncogene-encoded p185 molecule exert synergistic antitumor effects in vivo. Oncogene 2: 273?277

Fendly BF, Winget M, Hudziak RM, et al (1990) Characterization of monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2/neu gene product. Cancer Res 50: 1550?1558

Fernandez-Pol JA (1985) Epidermal growth factor receptor of A431 cells. Characterization of a monoclonal anti-receptor antibody noncompetitive agonist of epidermal growth factor action. J Biol Chem 260: 5003?5011

Freeman MR, Washecka R, Chung LWK (1989) Aberrant expression of epidermal growth factor receptor and HER-2 (erbB-2) messenger RNAs in human renal cancers. Cancer Res 49: 6221?6225

Fukushige S-I, Matsubara K-I, Yoshida M, et al (1986) Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell line. Mol Cell Biol 6: 955?958

Guérin M, Barrois M, Terrier M-J, et al (1988) Overexpression of either c-myc or c-erbB-2/neu protooncogenes in human breast carcinomas: correlation with poor prognosis. Oncogene Res 3: 21?31

Guérin M, Gabillot M, Mathieu M-C, et al (1989) Structure and expression of c-erbB-2 and EGF receptor genes in inflammatory and non-inflammatory breast cancer: prognostic significance. Int J Cancer 43: 201?208

Hama-Schroff RW, Foon KA, Beatty SM, et al (1985) Human antimurine immunoglobulin responses in patients receiving monoclonal antibody therapy. Cancer Res 45: 879?885

Hudziak RM, Lewis GD, Shalaby MR, et al (1988) Amplified expression of the HER2/erbB-2 oncogene induces resistance to tumor necrosis factor ? in NIH 3T3 cells. Proc Natl Acad Sci USA 85: 5102?5106

Hudziak RM Lewis GD, Winget M, et al (1989) p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor. Mol Cell Biol 9: 1165?1172

Hynes NE, Gerber HA, Saurer S, et al (1989) Overexpression of the c-erbB-2 protein in human breast tumor cell lines. J Cell Biochem 39: 167?173

Johnson BE, Makuch RW, Simmons AD, et al (1988)myc family DNA amplification in small cell lung cancer patients tumors and corresponding cell lines. Cancer Res 48: 5163?5166

Junghans RP, Walmann TA, Landolfi NF, et al (1990) Anti-Tac-H, a humanized antibody to the interleukin 2 receptor with new features for immunotherapy in malignant and immune disorders. Cancer Res 50: 1495?1502

Kameda T, Yasui W, Yoshida K, et al (1990) Expression oferbB2 in human gastric carcinomas: relationship between p185erbB2 expression and gene amplification. Cancer Res 50: 8002?8009

Kern JA, Schwartz DA, Nordberg JE, et al (1990) p185neu expression in human lung adenocarcinomas predicts shortened survival. Cancer Res 50: 5184?5191

King CR, Kraus MN, Aaronson SA (1985) Amplification of a novel v-erbB-related gene in a human mammary carcinoma. Science 229: 974?976

Krauss MH, Popescu NC, Amsbaugh SC, et al (1987) Overexpression of the EGF receptor-related proto-oncogeneerbB-2 in human mammary tumor cell lines by different molecular mechanisms. EMBO J 6: 605?610

Kraus MH, Issing W, Miki T, et al (1989) Isolation and characterization ofERBB3, a third member of the ?ERBB?/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc. Natl Acad Sci. USA 86: 9193?9197

Lee W-H, Murphree AL, Benedict WF (1984) Expression of the N-myc gene in primary retinoblastoma. Nature 309: 458?460

Liberman TA, Nusbaum HR, Razon N, et al (1985) Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human tumors of glial origin. Nature 313: 144?147

Lichtenstein A, Berenson J, Gera JF, et al (1990) Resistance of human ovarian cancer cells to tumor necrosis factor and lymphokineactivated killer cells: correlation with expression ofHER2/neu oncogenes. Cancer Res 50: 7364?7370

Little CD, Nau MM, Carney DN, et al (1983) Amplification and expression of the c-myc oncogene in human lung cancer cell lines. Nature 306: 194?196

Liu AY, Robinson RR, Hellström KE, et al (1987) Chimeric mousehuman IgG1 antibody that can mediate lysis of cancer cells. Proc Natl Acad Sci USA 84: 3439?3443

Merlino GT, Xu Y-H, Ishii S, et al (1984) Amplified and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells. Science 224: 417?419

Moriyama M, Akiyama T, Yamamoto T, et al (1991) Expression of C-ERBB-2 gene product in urinary bladder cancer. J Urol 145: 423?427

Park J-B, Rhim JS, Park S-C, et al (1989) Amplification, overexpression and rearrangement of theerbB-2 protooncogene in primary human stomach carcinomas. Cancer Res 49: 6605?6609

Perez R, Pascual M, Macias A, et al (1984) Epidermal growth factor receptors in human breast cancer. Breast Cancer Res Treat 4: 189?193

Reichmann L, Clark M, Waldmann H, et al (1988) Reshaping human antibodies for therapy. Nature 332: 323?329

Ro J, North SM, Gallick GE, et al (1988) Amplified and overexpressed epidermal growth factor receptor gene in uncultured primary human breast carcinoma. Cancer Res 48: 161?164

Sarup JC, Johnson RM, King KL, et al (1991) Characterization of an anti-p185HER2 monoclonal antibody that stimulates receptor function and inhibits tumor cell growth. Growth Regul 1: 72?82

Schechter AL, Stern DF, Vaidyanathan L, et al (1984) Theneu oncogene: anerbB-related gene encoding a 185,000-Mr tumor antigen. Nature 312: 513?516

Schechter AL, Hung M-C, Vaidyanathan L, et al (1985) Theneu gene: anerbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor. Science 229: 976?978

Schneider PM, Hung M-C, Chiocca SM, et al (1989) Differential expression of the c-erbB-2 gene in human small cell and non-small cell lung cancer. Cancer Res 49: 4968?4971

Seeger RC, Brodeur GH, Sather H, et al (1985) Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas. N Engl J Med 313: 1111?1116

Semba K, Kamato N, Toyoshima K, et al (1985) A v-erbB-related protooncogene, c-erbB-2 is distinct from the c-erbB-1/epidermal growth factor receptor gene and is amplified in a human salivary gland adenocarcinoma. Proc Natl Acad Sci USA 82: 6497?6501

Seshadri R, Matthews C, Dobrovic A, et al (1989) The significance of oncogene amplification in primary breast cancer. Int J Cancer 43: 270?272

Shalaby MR, Shepard HM, Presta L, et al (1992) The development of humanized bispecific antibodies reactive with cytotoxic lymphocytes and tumor cells overexpressing theHER2 protooncogene. J Exp Med 175: 217?225

Shawler DL, Bartholomew RM, Smith LM, et al (1985) Human immune response to multiple injections of murine monoclonal IgG. J Immunol 135: 1530?1535

Sias PE, Kotts CE, Vetterlein D, et al (1990) ELISA for quantitation of the extracellular domain of p185HER2 in biological fluids. J Immunol Methods 132: 73?80

Slamon DJ, DeKernion JB, Verma IM, et al (1984) Expression of cellular oncogenes in human malignancies. Science 224: 256?262

Slamon DJ, Clark GM, Wong SG, et al (1987) Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235: 177?182

Slamon DJ, Godolphin W, Jones LA, et al (1989) Studies of the HER-2/neu protooncogene in human breast and ovarian cancer. Science 244: 707?712

Stern DF, Heffernan PA, Weinberg RA (1986) p185, a product of theneu protooncogene, is a receptorlike protein associated with tyrosine kinase activity. Mol Cell Biol 6: 1729?1740

Tal M, Wetzler M, Josefberg Z, et al (1988) Sporadic amplification of the HER2/neu protooncogene in adenocarcinomas of various tissues. Cancer Res 48: 1517?1520

Tandon AK, Clark GM, Cuamness GC, et al (1989) HER2/neu oncogene protein and prognosis in breast cancer. J Clin Oncol 7: 1120?1128

Ullrich A, Coussens L, Hayflick JS, et al (1984) Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature 300: 418?425

van de Vijver M, van de Bersselaar R, Devilee P, et al (1987) Amplification of theneu (c-erbB-2) oncogene in human mammary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene. Mol Cell Biol 7: 2019?2023

van de Vijver MJ, Peterse JL, Mool WJ, et al (1988)Neu protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer. N Engl J Med 319: 1239?1245

Venter DJ, Kumar S, Tuzi NL, et al (1987) Overexpression of the c-erbB-2 oncoprotein in human breast carcinomas: immunohistological assessment correlates with gene amplification. Lancet 2: 69?72

Weinberg RA (1984)ras oncogenes and the molecular mechanisms of carcinogenesis. Blood 64: 1143?1145

Williams TN, Weiner DB, Greene MI, et al (1991) Expression of c-erbB-2 in human pancreatic adenocarcinomas. Pathobiology 59: 46?52

Wright C, Angus B, Nicholson S, et al (1989) Expression of c-erbB-2 oncoprotein: a prognostic indicator in human breast cancer. Cancer Res 49: 2087?2090

Yamamoto T, Kamato N, Kawano N, et al (1986) High incidence of amplification of epidermal growth factor receptor gene in human squamous carcinoma cell line. Cancer Res 46: 414?416

Yamazaki H, Fukui Y, Ueyama Y, et al (1988) Amplification of the structurally and functionally altered epidermal growth factor receptor gene (c-erb) in human brain tumors. Mol Cell Biol 8: 1816?1820

Yao M, Shuin T, Misaki H, et al (1988) Enhanced expression of c-myc and epidermal growth factor receptor (c-erbB1) genes in primary human renal cancer. Cancer Res 48: 6753?6757

Yokota J, Yamamoto T, Miyajima N, et al (1988) Genetic alterations of the c-erbB-2 oncogene occur frequently in tubular adenocarcinoma of the stomach and are often accompanied by amplification of the v-erbA homologue. Oncogene 2: 283?287

Yonemura Y, Ninomiya I, Yamaguchi A, et al (1991) Evaluation of immunorcactivity for erbB-2 protein as a marker of poor short term prognosis in gastric cancer. Cancer Res 51: 1034?1038

Zhou D, Battifora H, Yokota J, et al (1987) Association of multiple copies of the c-erbB-2 oncogene with spread of breast cancer. Cancer Res 47: 6123?6125