Differential effects of levetiracetam, carbamazepine, and lamotrigine on reproductive endocrine function in adults

Herzog, 1986, Reproductive endocrine disorders in women with partial seizures of temporal lobe origin, Arch Neurol, 43, 341, 10.1001/archneur.1986.00520040029014

Herzog, 2003, Interictal EEG discharges, reproductive hormones, and menstrual disorders in epilepsy, Ann Neurol, 54, 625, 10.1002/ana.10732

Herzog, 2003, Relationship of sexual dysfunction to epilepsy laterality and reproductive hormone levels in women, Epilepsy Behav, 4, 407, 10.1016/S1525-5050(03)00121-5

Isojärvi, 1990, Serum steroid hormones and pituitary function in female epileptic patients during carbamazepine therapy, Epilepsia, 31, 438, 10.1111/j.1528-1157.1990.tb05500.x

Isojärvi, 1995, Menstrual disorders in women with epilepsy receiving carbamazepine, Epilepsia, 36, 676, 10.1111/j.1528-1157.1995.tb01045.x

Svalheim, 2003, Do women with epilepsy have increased frequency of menstrual disturbances?, Seizure, 12, 529, 10.1016/S1059-1311(03)00195-X

Artama, 2006, Antiepileptic drug use and birth rate in patients with epilepsy: a population-based cohort study in Finland, Hum Reprod, 21, 2290, 10.1093/humrep/del194

Isojärvi, 1995, Carbamazepine, phenytoin, sex hormones and sexual functioning in men with epilepsy, Epilepsia, 36, 366, 10.1111/j.1528-1157.1995.tb01011.x

Røste, 2003, Alterations in semen parameters in men with epilepsy treated with valproate or carbamazepine monotherapy, Eur J Neurol, 100, 501, 10.1046/j.1468-1331.2003.00615.x

Herzog, 2005, Differential effects of antiepileptic drugs on sexual function and hormones in men with epilepsy, Neurology, 65, 1016, 10.1212/01.wnl.0000178988.78039.40

Herzog, 2004, Differential effects of antiepileptic drugs on sexual function and reproductive hormones in men with epilepsy: interim analysis of a comparison between lamotrigine and enzyme-inducing antiepileptic drugs, Epilepsia, 45, 764, 10.1111/j.0013-9580.2004.60703.x

Isojärvi, 2005, Effect of antiepileptic drugs on reproductive endocrine function in individuals with epilepsy, CNS Drugs, 19, 207, 10.2165/00023210-200519030-00003

Ben-Menachem, 2003, Levetiracetam: treatment in epilepsy, Expert Opin Pharmacother, 4, 2079, 10.1517/14656566.4.11.2079

Briggs, 2004, Levetiracetam safety profiles and tolerability in epilepsy patients, Expert Opin Drug Saf, 3, 415, 10.1517/14740338.3.5.415

Taubøll, 2006, Comparison of reproductive effects of levetiracetam and valproate studied in prepubertal porcine ovarian follicular cells, Epilepsia, 47, 1580, 10.1111/j.1528-1167.2006.00668.x

Svalheim, 2008, Long-term levetiracetam treatment affects reproductive endocrine function in female Wistar rats, Seizure, 17, 203, 10.1016/j.seizure.2007.11.018

Harden CL, Niklov B, Kandula P, Labar D, Pannullo S. Effect of levetiracetam on testosterone levels in male patients. Epilepsia, AES Abstracts; 2008. Available from: http://www.aesnet.org/go/publications/aes-abstracts/abstractsearch/?mode=display&st=harden&sy=2008&sb=Authors&startrow=1&id=893.

Lynch, 2004, The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam, Proc Natl Acad Sci USA, 101, 9861, 10.1073/pnas.0308208101

Bajjalieh, 1994, Differential expression of synaptic vesicle protein 2 (SV2) isoforms, J Neurosci, 14, 5223, 10.1523/JNEUROSCI.14-09-05223.1994

Portela-Gomes, 2000, Synaptic vesicle protein 2, a new neuroendocrine cell marker, Am J Pathol, 157, 1299, 10.1016/S0002-9440(10)64645-7

Löfgren, 2006, Effects of carbamazepine and oxcarbazepine on the reproductive endocrine function in women with epilepsy, Epilepsia, 47, 1441, 10.1111/j.1528-1167.2006.00506.x

Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia 1989;30:389–99.

Polson, 1988, Polycystic ovaries: a common finding in normal women, Lancet, 16, 870, 10.1016/S0140-6736(88)91612-1

McGahuey, 2000, The Arizona Sexual Experience Scale (ASEX): reliability and validity, J Sex Marital Ther, 26, 25, 10.1080/009262300278623

Vermeulen, 1999, A critical evaluation of simple methods for the estimation of free testosterone in serum, J Clin Endocrinol Metab, 84, 3666, 10.1210/jc.84.10.3666

Remes, 1979, Effect of long-term physical training on plasma testosterone, androstenedione, luteinizing hormone and sex-hormone-binding globulin capacity, Scand J Clin Lab Invest, 39, 743, 10.3109/00365517909108166

Herzog, 2008, Disorders of reproduction in patients with epilepsy: primary neurological mechanisms, Seizure, 17, 101, 10.1016/j.seizure.2007.11.025

Isojärvi, 1989, Effects of carbamazepine on the hypothalamic–pituitary–gonadal axis in male patients with epilepsy: a prospective study, Epilepsia, 30, 446, 10.1111/j.1528-1157.1989.tb05324.x

Rodin, 1984, Investigation of sex hormones in male epileptic patients, Epilepsia, 25, 690, 10.1111/j.1528-1157.1984.tb03478.x

Toone, 1980, Sex hormone changes in male epileptics, Clin Endocrinol, 12, 391, 10.1111/j.1365-2265.1980.tb02726.x

Toone, 1983, Sex hormones, sexual activity and plasma anticonvulsant levels in male epileptics, J Neurol Neurosurg Psychiatry, 46, 824, 10.1136/jnnp.46.9.824

Webber, 1986, Fertility in persons with epilepsy: 1935–1974, Epilepsia, 27, 746, 10.1111/j.1528-1157.1986.tb03605.x

Laumann, 1999, Sexual function in the United States: prevalence and predictors, JAMA, 281, 537, 10.1001/jama.281.6.537

Gil-Nagel, 2006, Effect of lamotrigine on sexual function in patients with epilepsy, Seizure, 15, 142, 10.1016/j.seizure.2005.12.006

ZarZar, 2007, Effectiveness and weight effects of open-label lamotrigine with and without concomitant psychotropic medications in patients with bipolar I disorder, Med Gen Med, 9, 41

Miller, 2008, Depressive symptoms in epilepsy: prevalence, impact, aetiology, biological correlates and effect of treatment with antiepileptic drugs, Drugs, 68, 1493, 10.2165/00003495-200868110-00003

Ciesielski, 2006, Neuropsychological and psychiatric impact of add-on titration of pregabalin versus levetiracetam: a comparative short-term study, Epilepsy Behav, 9, 424, 10.1016/j.yebeh.2006.07.011

Mazza, 2008, Effect of levetiracetam on depression and anxiety in adult epileptic patients, Prog Neuropsychopharmacol Biol Psychiatry, 32, 539, 10.1016/j.pnpbp.2007.10.015

Gastaut, 1954, Sexual behavior in psychomotor epileptics, Ann Med Psychol (Paris), 112, 657

Fenwick, 1985, Sexual behavior in a centre for epilepsy, Acta Neurol Scand, 71, 428, 10.1111/j.1600-0404.1985.tb03225.x

Jensen, 1990, Sexual dysfunction in male and female patients with epilepsy: a study of 86 outpatients, Arch Sex Behav, 19, 1, 10.1007/BF01541822

Mölleken, 2009, Sexual quality of life in epilepsy: correlations with sex hormone blood levels, Epilepsy Behav, 14, 226, 10.1016/j.yebeh.2008.10.015

Talbot, 2008, Sexual function in men with epilepsy: how important is testosterone?, Neurology, 70, 1346, 10.1212/01.wnl.0000311242.51618.b7