Differential Effect of Anti-B7-1 and Anti-M150 Antibodies in Restricting the Delivery of Costimulatory Signals from B Cells and Macrophages
Tóm tắt
B7-1 and M150 are potent costimulatory molecules expressed on B cells and macrophages. We have examined the capacity of Abs against B7-1 and M150 in differentially inhibiting the costimulatory signals delivered by macrophages and B cells to OVA-specific CD4+ T cells. The anti-B7-1 Ab significantly blocked the proliferation of Th cells, MLR, T cell help to B cells, and secretion of IFN-γ when B cells were used to provide costimulation, but not when macrophages were used. In contrast, anti-M150 Ab significantly decreased the proliferation of Th cells, MLR, and production of IFN-γ, when macrophages were utilized to provide costimulatory signals, but not when B cells were used as APC. However, when macrophages activated with IFN-γ were used as a source of costimulation, like anti-M150 Ab, Ab to B7-1 also down-regulated the activation of Th cells. The significance of this finding is that M150 is a potent first costimulatory signal for initiating proliferation and secretion of IFN-γ and providing cognate help for B cells by Th cells when the macrophage is used as an accessory cell. M150-induced IFN-γ production induces the expression of B7-1 on the surface of macrophages, which then delivers a second cosignal for Th cells. B7-1 works efficiently when B cell provides cosignal. Both of the molecules promote Th1 activity, as evidenced by the inhibition of the secretion of IFN-γ but not IL-4 by Th cells with anti-M150 and B7-1 Abs.
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Mueller, D. L., M. K. Jenkins, R. H. Schwartz. 1989. Clonal expansion versus clonal inactivation: a costimulatory signaling pathway determines the outcome of T cell antigen receptor occupancy. Annu. Rev. Immunol. 7: 455
Dubey, C., M. Croft, S. L. Swain. 1995. Costimulatory requirements of naive CD4+ T cells: ICAM-1 or B7-1 can costimulate naive CD4+ T cell activation but both are required for optimum response. J. Immunol. 155: 45
Liu, Y., B. Jones, A. Aruffo, K. M. Sullivan, P. S. Linsley, C. A. Janeway, Jr. 1992. Heat-stable antigen is a costimulatory molecule for CD4+ T cell growth. J. Exp. Med. 175: 437
Damle, N. K., K. Klussman, P. S. Linsley, A. Aruffo. 1992. Differential costimulatory effects of adhesion molecules B7, ICAM-1, LFA-3, and VCAM-1 on resting and antigen-primed CD4+ T lymphocytes. J. Immunol. 148: 1985
Agrewala, J. N., D. S. Vinay, A. Joshi, G. C. Mishra. 1994. A 150-kDa molecule of macrophage membrane stimulates interleukin-2 and interferon-γ production and proliferation of ovalbumin-specific CD4+ T cells. Eur. J. Immunol. 24: 2092
Reiser, H., G. J. Freeman, Z. R. Wolf. C. D. Gimmi, B. Benacerraf, L. M. Nadler. 1992. Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex. Proc. Natl. Acad. Sci. USA 89: 271
Mosmann, T. R., M. Cherwinski, M. W. Bond, M. A. Gieldin, R. L. Coffman. 1986. Two types of murine T cell clones. 1. Definition according to profiles of lymphokines activities and secreted proteins. J. Immunol. 136: 2348
Scot, P., S. H. E. Kaufmann. 1991. The role of T-cell subsets and cytokines in the regulation of infection. Immunol. Today 12: 346
Williams, I. R., E. R. Unanue. 1990. Costimulatory requirements of murine Th1 clones: the role of accessory cell-derived signals in responses to anti-CD3 antibody. J. Immunol. 145: 85
Weaver, C. T., C. M. Hawrylowicz, E. R. Unanue. 1988. T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells. Proc. Natl. Acad. Sci. USA 85: 8181
Kuchroo, V. K., M. P. Das, J. A. Brown, A. M. Ranger, S. S. Zamvil, R. A. Sobel, M. L. Weiner, N. Nabavi, L. H. Glimcher. 1995. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 80: 707
Abbas, A. K., K. M. Murphy, A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature 383: 787
Freeman, G. J., V. A. Boussiotis, A. Anumanthan, G. M. Bernstein, X. Y. Ke, P. D. Rennert, G. S. Gray, J. G. Gribben, L. M. Nadler. 1995. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4. Immunity 2: 253
Ranger, A. M., M. Prabhu Das, V. K. Kuchroo, L. H. Glimcher. 1997. B7-2 (CD86) is essential for the development of interleukin-4 producing T cells. Int. Immunol. 8: 1549
Liu, Y., B. Jones, W. Brady, C. A. Janeway, Jr, P. S. Linsley. 1992. Costimulation of murine CD4+ T cell growth: cooperation between B7 and heat-stable antigen. Eur. J. Immunol. 22: 2855
Johnson, J. G., M. K. Jenkins. 1994. Monocytes provide a novel costimulatory signal to T cells that is not mediated by the CD28/B7 interaction. J. Immunol. 152: 429
Gravestein, L. A., J. D. Nieland, A. M. Kruisbeck, J. Borst. 1995. Novel mAbs reveal potent co-stimulatory activity of murine CD28. Int. Immunol. 7: 551
Pollock, K. E., Y-J. Kim, Z. Zhou, J. Hurtado, K. K. Kim, R. T. Pickard, B. S. Kwon. 1993. Inducible T cell antigen 4-1BB: analysis of expression and function. J. Immunol. 150: 771
Green, J. M., X-G. Zheng, Y. Simizu, C. B. Thomposon, L. A. Turka. 1994. T cell receptor stimulation, but not CD28 costimulation, is dependent on LFA-1-mediated events. Eur. J. Immunol. 24: 265
Cayabyab, M., J. H. Phillips, L. L. Lanier. 1994. CD40 preferentially costimulates activation of CD4+ T lymphocytes. J. Immunol. 52: 1523
Kennedy, M. K., K. M. Mohler, K. D. Shanebeck, P. R. Baum, K. S. Picha, C. A. Otten-Evans, C. A. Janeway, Jr, K. H. Grabstein. 1994. Induction of B cell stimulatory function by recombinant murine CD40 ligand. Eur. J. Immunol. 24: 116
Sperling, A. I., J. M. Green, R. L. Mosley, P. L. Smith, R. J. Dipaolo, J. R. Klein, J. A. Bluestone, C. B. Thompson. 1995. CD43 is a murine T cell costimulatory receptor that functions independently of CD28. J. Exp. Med. 182: 139
Cocks, B. G., C-C. J. Chang, J. M. Carballido, H. Yssel, J. E. de Vries, G. Aversa. 1995. A novel receptor involved in T-cell activation. Nature 376: 260
Ding, L., E. M. Shevach. 1996. Activated B cells express CD28/B7-independent costimulatory activity. J. Immunol. 157: 1389
Green, J. M., P. J. Noel, A. I. Soerling, T. L. Walunas, G. S. Gray, J. A. Bluestone, C. B. Thompson. 1994. Absence of B-7-dependent responses in CD-28 deficient mice. Immunity 1: 501
Freedman, A. S., G. Freeman, J. E. Horowitz, J. Daley, L. M. Nadler. 1987. B7, a B cell-restricted antigen that identifies preactivated B cells. J. Immunol. 139: 3260
Freedman, A. S., G. Freeman, K. Rhynhart, L. M. Nadler. 1991. Selective induction of B7/BB-1 on IFN-γ stimulated monocytes: a potential mechanism for amplification of T cell activation through the CD28 pathway. Cell. Immunol. 137: 429
Ding, L., P. S. Linsley, L. Y. Huang, R. N. Germain, E. M. Shevach. 1993. IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7-expression. J. Immunol. 151: 1224
Stoppelli, M., C. Tacchetti, M. U. Cubellis, A. Corti, V. J. Hearing, G. Cassani, E. Apella, F. Blasi. 1986. Saturation of protein kinase receptors on human A431 cells. Cell 45: 675
Laemmli, U.. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 277: 680
Bradford, M. M.. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248
Agarwal, A. K., A. Singhal, C. M. Gupta. 1987. Functional drug targeting to erythrocytes in vivo using antibody bearing liposomes as drug vehicles. Biochem. Biophys. Res. Commun. 184: 357
Towbin, H., T. Staehelin, J. Gordan. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 76: 4350
Kimoto, M., C. G. Fathman. 1980. Antigen reactive T cell clones. 1. Transcomplementary hybrid IA-region gene products function effectively in antigen presentation. J. Exp. Med. 164: 580
Fernandez-Botran, R., P. H. Krammer, T. Diamanstein, J. W. Uhr, E. S. Vitetta. 1986. B-cell stimulatory factor-1 promotes growth of helper T cell lines. J. Exp. Med. 164: 580
Reynolds, D. S., W. H. Boom, A. K. Abbas. 1987. Inhibition of B lymphocytes activation by interferon-gamma. J. Immunol. 139: 767
Shahinian, A., K. Pfeffer, K. P. Lee, T. M. Kundig, K. Kishihara, A. Wakeham, K. Kawai, P. S. Ohashi, C. B. Thompson, T. W. Mak. 1993. Differential T cell costimulatory requirement in CD28-deficient mice. Science 261: 609
Ding, L., J. M. Green, C. B. Thompson, E. M. Shevach. 1995. B7/CD28-dependent and-independent induction of CD40 ligand expression. J. Immunol. 155: 5124
Ronchese, F., B. Hausmann, S. Hubele, P. Lane. 1994. Mice transgenic for a soluble form of murine CTLA-4 show enhanced expansion of antigen-specific CD4+ T cells and defective antibody production in vivo. J. Exp. Med. 179: 809
Seder, R. A., W. E. Paul, M. M. Davis, B. F. de St. Groth.. 1992. The presence of interleukin-4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. J. Exp. Med. 176: 1091
Sher, A., R. L. Coffman. 1992. Regulation of immunity to parasites by T cells and T cell derived cytokines. Annu. Rev. Immunol. 10: 385
Shamafelt, M-C., C. Soderberg, A. Allsup, D. Adelwavy, G. Pettz, R. Laheswaa. 1994. Costimulatory signals can selectively modulate cytokine production by subsets of CD4+ T cells. J. Immunol. 154: 1684
Palmer, E. M., G. A. van Seventer. 1997. Human T helper cell differentiation is regulated by the combined action of cytokines and accessory cell-dependent costimulatory signals. J. Immunol. 158: 2654
Gajewski, T., M. Pinnas, T. Wong, F. W. Fitch. 1991. Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations. J. Immunol. 146: 1750
Chang, T., C. M. Shea, S. Urioste, R. C. Thompson, W. H. Boom, A. K. Abbas. 1990. Heterogeneity of helper/inducer T lymphocytes. III. Responses of IL-2 and IL-4 producing (Th1 and Th2) clones to antigen presenting by different accessory cells. J. Immunol. 145: 2803
Stevens, T. L., A. Bossie, V. M. Sanders, R. Fernandez-Botran, R. L. Coffman, T. R. Mosmann, E. S. Vitetta. 1988. Regulation of antibody isotype secretion by subsets of antigen specific helper T cells. Nature 334: 225
Snapper, C. M., W. E. Paul. 1987. Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 236: 944
Kubin, M., M. Kamoun, G. Trinchieri. 1994. Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells. J. Exp. Med. 180: 222
Murphy, E. E., G. Terres, S. E. Macatonia, C. S. Hsieh, J. Mattson, L. Lanier, M. Wysocka, G. Trinchieri, K. Murphy, A. O’Garra. 1994. B7 and interleukin 12 cooperate for proliferation and interferon-γ production by mouse T helper clones that are unresponsive to B7 costimulation. J. Exp. Med. 180: 231
Kohno, K., J. Kataoka, T. Ohtsuki, Y. Suemoto, I. Okamoto, M. Usui, M. Ikeda, M. Kurimoto. 1997. IFN-γ-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12. J. Immunol. 158: 1541
Stern, A. S., F. J. Podlaski, J. D. Hulmes, Y. C. E. Pan, P. M. Wuinn, A. G. Wolitzky, P. C. Familletti, D. L. Stremlo, T. Truitt, R. Chizzonite, M. K. Gately. 1990. Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc. Natl. Acad. Sci. USA 87: 6808