Different transmitter transients underlie presynaptic cell type specificity of GABA <sub>A,slow</sub> and GABA <sub>A,fast</sub>

Proceedings of the National Academy of Sciences of the United States of America - Tập 104 Số 37 - Trang 14831-14836 - 2007
János Szabadics1,2, Gábor Tamás2,3, Iván Soltész4
1Department of Anatomy and Neurobiology, University of California, 193 Irvine Hall, Irvine, CA 92697, USA.
2HAS Research Group for Cortical Microcircuits, Department of Comparative Physiology, University of Szeged, Kozep fasor 52, H-6726, Szeged, Hungary
3Szegedi Tudomanyegyetem
4*Department of Anatomy and Neurobiology, University of California, 193 Irvine Hall, Irvine, CA 92697; and

Tóm tắt

Phasic (synaptic) and tonic (extrasynaptic) inhibition represent the two most fundamental forms of GABA A receptor-mediated transmission. Inhibitory postsynaptic currents (IPSCs) generated by GABA A receptors are typically extremely rapid synaptic events that do not last beyond a few milliseconds. Although unusually slow GABA A IPSCs, lasting for tens of milliseconds, have been observed in recordings of spontaneous events, their origin and mechanisms are not known. We show that neocortical GABA A,slow IPSCs originate from a specialized interneuron called neurogliaform cells. Compared with classical GABA A,fast IPSCs evoked by basket cells, single spikes in neurogliaform cells evoke extraordinarily prolonged GABA A responses that display tight regulation by transporters, low peak GABA concentration, unusual benzodiazepine modulation, and spillover. These results reveal a form of GABA A receptor mediated communication by a dedicated cell type that produces slow ionotropic responses with properties intermediate between phasic and tonic inhibition.

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Proceedings of the National Academy of Sciences of the United States of America

Tập 104 Số 37

14831-14836

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