Diethyldithiocarbamate suppresses the plant activation of aromatic amines into mutagens by inhibiting tobacco cell peroxidase

Ames, 1972, Carcinogens as frameshift mutagens: metabolites and derivatives of 2-acetylaminofluorene and other aromatic amine carcinogens, 69, 3128 Ames, 1975, Hair dyes are mutagenic: identification of a variety of mutagenic ingredients, 72, 2423 Boyd, 1984, Evidence for a one-electron mechanism of 2-aminofluorene oxidation by prostaglandin H synthase and horseradish peroxidase, J. Biol. Chem., 259, 13885, 10.1016/S0021-9258(18)89829-5 Boyd, 1983, The oxidation of 2-aminofluorene by prostaglandin endoperoxide synthetase, J. Biol. Chem., 258, 8246, 10.1016/S0021-9258(20)82056-0 Bradford, 1976, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal. Biochem., 72, 248, 10.1016/0003-2697(76)90527-3 Chance, 1955, Assay of catalases and peroxidases, Vol. 2, 764 Forman, 1980, Mechanism for the potentiation of oxygen toxicity by disulfiram, J. Pharmacol. Exp. Ther., 212, 452 Gichner, 1984, Inhibition of dimethyl-nitrosamine-induced mutagenesis in Arabidopsis thliana by diethyldithiocarbamate and carbon monoxide, Mutation Res., 139, 29, 10.1016/0165-7992(84)90118-0 Gichner, 1988, Antimutagenic effects of diethyldithiocarbamate towards maleic hydrazide- and N-nitrosodiethylamine-induced mutagenicity in the Tradescantia mutagenicity assay, Biol. Plant., 30, 14, 10.1007/BF02876417 Heikkila, 1985, Inactivation of superoxide dismutase by diethyldithiocarbamate, 387 Higashi, 1988, Metabolic activation of environmental chemicals by microsomal enzymes of higher plants, Mutation Res., 197, 273, 10.1016/0027-5107(88)90098-X Higashi, 1983, Isolation of immunochemically distinct form of cytochrome P-450 from microsomes of tulip bulbs, Biochem. Biophys. Res. Commun., 115, 46, 10.1016/0006-291X(83)90966-X Higashi, 1985, Purification of a single major form of microsomal cytochrome P-450 from tulip bulbs (Tulipa gesneriana L), Agric. Biol. Chem., 49, 2399, 10.1271/bbb1961.49.2399 Kawanishi, 1985, Relation between hepatic microsomal metabolism of N-nitrosamines and cytochrome P-450 species, Biochem. Pharmacol., 34, 919, 10.1016/0006-2952(85)90590-8 Kleiman, 1990, Hydrogen peroxide-induced DNA damage in bovine lens epithelial cells, Mutation Res., 240, 35, 10.1016/0165-1218(90)90006-N Kuwahara, 1988, Purification of an aromatic amine-dependent NAD(P)H oxidase from tomato fruit and its characterization as a peroxidase, Agric. Biol. Chem., 52, 2597, 10.1271/bbb1961.52.2597 Lhotka, 1987, Plant activation of m-phenylenediamine by tobacco, cotton, and carrot cells suspension cultures, Environ. Mol. Mutagen., 10, 79, 10.1002/em.2850100109 Lotlikar, 1975, Ring- and N-hydroxylation of 2-acetamidofluorene by rat liver reconstituted crytochrome P-450 enzyme system, Biochem. J., 150, 561, 10.1042/bj1500561 Lutz, 1973, Protection by diethyldithiocarbamate against carbon tetrachloride lethality in rats and against carbon tetrachloride induced lipid peroxidation in vitro, Biochem. Pharmacol., 22, 1729, 10.1016/0006-2952(73)90386-9 Mäder, 1986, De-novo synthesis and release of peroxidases in cell suspension cultures of Nicotiana tabacum L, Planta, 169, 273, 10.1007/BF00392325 Maehly, 1954, The assay of catalases and peroxidases, Vol. 1, 357 Miller, 1969, Studies on the mechanism of activation of aromatic amine and amide carcinogens to ultimate carcinogenic electrophilic reactants, Ann. N.Y. Acad. Sci., 163, 731, 10.1111/j.1749-6632.1969.tb24891.x Murashige, 1962, A revised medium for rapid growth and bioassays with tobacco cultures, Physiol. Plant., 15, 473, 10.1111/j.1399-3054.1962.tb08052.x Plewa, 1983, The activation of 2-aminofluorene by cultured plant cells, Science, 219, 1427, 10.1126/science.6338591 Plewa, 1988, The plant cell/microbe coincubation assay for the analysis of plant-activated promutagens, Mutation Res., 197, 207, 10.1016/0027-5107(88)90094-2 Rojanapo, 1986, Carcinogenicity of an oxidation product of p-phenylenediamine, Carcinogenesis, 7, 1997, 10.1093/carcin/7.12.1997 Sanderman, 1982, Metabolism of environmental chemicals: a comparison of plant and liver enzyme systems, Vol. I, 1 Smith, 1989, Protein content of tobacco cells in relation to the plant activation of m-phenylenediamine and 2-aminofluorene, Environ. Mol. Mutagen., 14, 188 Takahama, 1989, A role of hydrogen peroxide in the metabolism of phenolics in mesophyll cells of Vicia faba L, Plant Cell Physiol., 30, 295, 10.1093/oxfordjournals.pcp.a077742 Wagner, 1989, Effect of specific monooxygenase and oxidase inhibitors on the activation of 2-aminofluorene by plant cells, Mutation Res., 216, 163, 10.1016/0165-1161(89)90002-2 Wagner, 1990, The biochemical mechanisms of the plant activation of promutagenic aromatic amines, Environ. Mol. Mutagen., 15, 236, 10.1002/em.2850150411 Watanabe, 1989, Phenazine derivatives as the mutagenic reaction product from o or m-pheylenediamine derivatives with hydrogen peroxide, Mutation Res., 227, 135, 10.1016/0165-7992(89)90037-7 Zanocco, 1989, Antioxidant capacity of diethyldithiocarbamate in a metal independent lipid peroxidative process, Free Radical Biology and Medicine, 7, 151, 10.1016/0891-5849(89)90006-3