Dietary supplemented antimicrobial peptide microcin J25 improves the growth performance, apparent total tract digestibility, fecal microbiota, and intestinal barrier function of weaned pigs1,2

2007, IL-1β causes an increase in intestinal epithelial tight junction permeability, J. Immunol., 178, 4641, 10.4049/jimmunol.178.7.4641

AOAC, 2006, Official methods of analysis., 18th ed.

2000, Antibiotic use in animal feed and its impact on human health, Nutr. Res. Rev., 13, 279, 10.1079/095442200108729106

2003, The use of a model ileum to investigate the effects of novel and existing antimicrobials on indigenous porcine gastrointestinal microflora: Using vancomycin as an example, Anim. Feed Sci. Technol., 103, 123, 10.1016/S0377-8401(02)00286-9

1999, The cyclic structure of microcin J25, a 21-residue peptide antibiotic from Escherichia coli, Eur. J. Biochem., 259, 747, 10.1046/j.1432-1327.1999.00085.x

2014, Role of the intestinal microbiota in resistance to colonization by Clostridium difficile, Gastroenterology, 146, 1547, 10.1053/j.gastro.2014.01.059

2009, Cytokine regulation of tight junctions, Biochim. Biophys. Acta, 1788, 864, 10.1016/j.bbamem.2008.08.027

1998, Supplementation of konjac glucomannan into a low-fiber Chinese diet promoted bowel movement and improved colonic ecology in constipated adults: A placebo-controlled, diet-controlled trial, J. Am. Coll. Nutr., 27, 102

2011, Evaluation of multi-microbe probiotics prepared by submerged liquid or solid substrate fermentation and antibiotics in weaning pigs, Livest. Sci., 138, 144, 10.1016/j.livsci.2010.12.015

2010, Interaction of cationic antimicrobial peptides with phospholipid vesicles and their antibacterial activity, Peptides, 31, 1811, 10.1016/j.peptides.2010.06.021

2011, Designing antimicrobial peptides: Form follows function, Nat. Rev. Drug Discov., 11, 37

2013, Changes in gut microbial populations, intestinal morphology, expression of tight junction proteins, and cytokine production between two pig breeds after challenge with Escherichia coli K88: A comparative study, J. Anim. Sci., 91, 5614, 10.2527/jas.2013-6528

2015, Antibiotic adjuvants: Diverse strategies for controlling drug-resistant pathogens, Chem. Biol. Drug Des., 85, 56, 10.1111/cbdd.12478

2007, Antimicrobial peptides: An overview of a promising class of therapeutics, Open Life Sci., 2, 1, 10.2478/s11535-007-0010-5

2010, Functional changes of intestinal mucosal barrier in surgically critical patients. World J, Emerg. Med., 1, 205

2006, Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies, Nat. Biotechnol., 24, 1551, 10.1038/nbt1267

2013, Gastrointestinal health and function in weaned pigs: A review of feeding strategies to control post-weaning diarrhoea without using in-feed antimicrobial compounds, J. Anim. Physiol. Anim. Nutr., 97, 207, 10.1111/j.1439-0396.2012.01284.x

2008, Effects of potato (Solanum tuberosum L. cv. Golden valley) protein having antimicrobial activity on the growth performance, and intestinal microflora and morphology in weaning pigs, Anim. Feed Sci. Technol., 140, 139, 10.1016/j.anifeedsci.2007.12.006

2008, Potato (Solanum tuberosum L. cv. Golden valley) protein as a novel antimicrobial agent in weanling pigs, J. Anim. Sci., 86, 1562, 10.2527/jas.2007-0414

1997, Inhibition of growth by pro-inflammatory cytokines: An integrated view, J. Anim. Sci., 75, 1244, 10.2527/1997.7551244x

2009, Insights into the biosynthesis and stability of the lasso peptide capistruin, Chem. Biol., 16, 1290, 10.1016/j.chembiol.2009.11.009

2015, Antimicrobial peptide CMA3 derived from the CA-MA hybrid peptide: Antibacterial and anti-inflammatory activities with low cytotoxicity and mechanism of action in Escherichia coli, Antimicrob. Agents Chemother., 60, 495

2000, Effect of feed antibiotics on the performance and intestinal microflora of weaning pigs in China. Asian-Australas, J. Anim. Sci., 13, 1554

2008, Interferon-gamma and tumor necrosis factor-alpha disrupt epithelial barrier function by altering lipid composition in membrane microdomains of tight junction, Clin. Immunol., 126, 67, 10.1016/j.clim.2007.08.017

2011, Effect of antibiotic growth promoters on intestinal microbiota in food animals: A novel model for studying the relationship between gut microbiota and human obesity? Front, Microbiol., 2, 53

2007, Efficacy of microcin J25 in biomatrices and in a mouse model of Salmonella infection, J. Antimicrob. Chemother., 59, 676, 10.1093/jac/dkm009

1999, Cytokine regulation of epithelial permeability and ion transport, Gut, 44, 283, 10.1136/gut.44.2.283

2013, Simultaneous immunochemical detection of four banned antibiotic growth promoters in raw and cooked poultry tissue. Food Addit. Contam., Part A, Chem. Anal. Control Expo, Risk Assess., 30, 1270

2011, The European ban on antibiotic growth promoters in animal feed: From challenges to opportunities, Vet. J., 187, 143, 10.1016/j.tvjl.2010.05.001

2006, Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig, Am. J. Physiol. Gastrointest. Liver Physiol., 292, G173

1993, Serum d-lactate levels as a predictor of acute intestinal ischemia in a rat model, J. Surg. Res., 54, 507, 10.1006/jsre.1993.1078

NRC, 2012, Nutrient requirements of swine, Natl.Acad. Press,, 11th rev. ed

2012, Biosynthesis and engineering of lasso peptides, PhD Diss.

2016, Use of recombinant porcine β-defensin 2 as a medicated feed additive for weaned pigs, Sci. Rep., 6, 26790, 10.1038/srep26790

2004, Weaning is associated with an upregulation of expression of inflammatory cytokines in the intestine of pigs, J. Nutr., 134, 641, 10.1093/jn/134.3.641

2010, Cytokine profiles, apoptosis and pathology of experimental Pasteurella multocida serotype A1 infection in mice, Res. Vet. Sci., 89, 332, 10.1016/j.rvsc.2010.04.012

2004, Microcin J25, from the macrocyclic to the lasso structure: Implications for biosynthetic, evolutionary and biotechnological perspectives, Curr. Protein Pept. Sci., 5, 383, 10.2174/1389203043379611

2015, Effects of casein glycomacropeptide supplementation on growth performance, intestinal morphology, intestinal barrier permeability and inflammatory responses in Escherichia coli K88 challenged pigs, Anim. Nutr., 1, 54, 10.1016/j.aninu.2015.05.006

2000, Antibacterial activity evaluation of microcin J25 against diarrheagenic Escherichia coli, Appl. Environ. Microbiol., 66, 4595, 10.1128/AEM.66.10.4595-4597.2000

1992, Microcin 25, a novel antimicrobial peptide produced by Escherichia coli, J. Bacteriol., 174, 7428, 10.1128/jb.174.22.7428-7435.1992

2016, Microcins mediate competition among Enterobacteriaceae in the inflamed gut, Nature, 540, 280, 10.1038/nature20557

2010, Early weaning stress impairs development of mucosal barrier function in the porcine intestine, Am. J. Physiol. Gastrointest. Liver Physiol., 298, G352, 10.1152/ajpgi.00081.2009

1986, Use of d-lactic acid measurements in the diagnosis of bacterial infections, J. Infect. Dis., 154, 658, 10.1093/infdis/154.4.658

2009, Soluble intercellular adhesion molecule-1, d-lactate and diamine oxidase in patients with inflammatory bowel disease. World J, Gastroenterol., 15, 3916

2015, A comparison of diets supplemented with a feed additive containing organic acids, cinnamaldehyde and a permeabilizing complex, or zinc oxide, on post-weaning diarrhoea, selected bacterial populations, blood measures and performance in weaned pigs experimentally infected with enterotoxigenic Escherichia coli, Animal, 5, 1147, 10.3390/ani5040403

2012, Dietary supplementation with recombinant lactoferrampin-lactoferricin improves growth performance and affects serum parameters in pigs, J. Anim. Vet. Adv., 11, 2548, 10.3923/javaa.2012.2548.2555

2013, Alternatives to antibiotics as growth promoters for use in swine production: A review, J. Anim. Sci. Biotechnol., 4, 35, 10.1186/2049-1891-4-35

2010, Alternatives to antibiotic growth promoters in prevention of diarrhoea in weaned pigs: A review, Vet. Med. (Praha), 55, 199, 10.17221/2998-VETMED

2016, Recombinant plectasin elicits similar improvements in the performance and intestinal mucosa growth and activity in weaned pigs as an antibiotic, Anim. Feed Sci. Technol., 211, 216, 10.1016/j.anifeedsci.2015.12.003

2011, Dietary supplementation with the probiotic Lactobacillus fermentum I5007 and the antibiotic aureomycin differentially affects the small intestinal proteomes of weaning pigs, J. Nutr., 142, 7

2007, Effects of the lactoferrin (LF) on the growth performance, intestinal microflora and morphology of weaning pigs, Anim. Feed Sci. Technol., 135, 263, 10.1016/j.anifeedsci.2006.07.013

1994, Diamine oxidase-an overview of historical, biochemical and functional aspects, Dig. Dis., 12, 2, 10.1159/000171432

2012, Effects of the antimicrobial peptide cecropin AD on performance and intestinal health in weaned pigs challenged with Escherichia coli, Peptides, 35, 225, 10.1016/j.peptides.2012.03.030

2014, Effects of antimicrobial peptides in nursery diets on growth performance of pigs reared on five different farms, Livest. Sci., 167, 206, 10.1016/j.livsci.2014.04.024

2006, Molecular mechanism of tumor necrosis factor-alpha modulation of intestinal epithelial tight junction barrier, Am. J. Physiol. Gastrointest. Liver Physiol., 290, G496, 10.1152/ajpgi.00318.2005

2016, High therapeutic efficacy of Cathelicidin-WA against postweaning diarrhea via inhibiting inflammation and enhancing epithelial barrier in the intestine, Sci. Rep., 6, 25679, 10.1038/srep25679

2013, A systematic review of antibiotic utilization in China, J. Antimicrob. Chemother., 68, 2445, 10.1093/jac/dkt223

2014, Effects of dietary supplementation of synthetic antimicrobial peptide-A3 and P5 on growth performance, apparent total tract digestibility of nutrients, fecal and intestinal microflora and intestinal morphology in weaning pigs, Livest. Sci., 159, 53, 10.1016/j.livsci.2013.10.025

2013, Effects of dietary supplementation with antimicrobial peptide-P5 on growth performance, apparent total tract digestibility, faecal and intestinal microflora and intestinal morphology of weaning pigs, J. Sci. Food Agric., 93, 587, 10.1002/jsfa.5840

2002, Antimicrobial peptides of multicellular organisms, Nature, 415, 389, 10.1038/415389a

2014, Serum diamine oxidase as a hemorrhagic shock biomarker in a rabbit model, PLoS One, 9, e102285, 10.1371/journal.pone.0102285

2011, Effects of soybean agglutinin on intestinal barrier permeability and tight junction protein expression in weaned piglets, Int. J. Mol. Sci., 12, 8502, 10.3390/ijms12128502