Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease

Neurochemistry International - Tập 54 Số 2 - Trang 111-118 - 2009
Saravanan S. Karuppagounder1, John T. Pinto2, Hui Xu1, Huan‐Lian Chen1, M. Flint Beal3, Gary E. Gibson1
1Department of Neurology and Neurosciences, Weill Medical College of Cornell University, Burke Medical Research Institute, 785 Mamaroneck Ave., White Plains, NY 10605, United States
2Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, United States
3Department of Neurology and Neurosciences, Weill Medical College of Cornell University, 525E, 68th Street, New York, NY 10021, United States

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Asensi, 2002, Inhibition of cancer growth by resveratrol is related to its low bioavailability, Free Rad. Biol. Med., 33, 387, 10.1016/S0891-5849(02)00911-5

Baker, 1987, Pharmacologic role of cysteine in ameliorating or exacerbating mineral toxicities, J. Nutr., 117, 1003, 10.1093/jn/117.6.1003

Balaban, 2005, Mitochondria, oxidants, and aging, Cell, 120, 483, 10.1016/j.cell.2005.02.001

Baur, 2006, Resveratrol improves health and survival of mice on a high-calorie diet, Nature, 444, 337, 10.1038/nature05354

Beal, 2005, Mitochondria take center stage in aging and neurodegeneration, Ann. Neurol., 58, 495, 10.1002/ana.20624

Belguendouz, 1997, Resveratrol inhibits metal ion-dependent and independent peroxidation of porcine low-density lipoproteins, Biochem. Pharmacol., 53, 1347, 10.1016/S0006-2952(96)00820-9

Bertelli, 1998, Stability of resveratrol over time and in the various stages of grape transformation, Drugs Under Exp. Clin. Res., 24, 207

Bubber, 2005, Mitochondrial abnormalities in Alzheimer brain: mechanistic implications, Ann. Neurol., 57, 695, 10.1002/ana.20474

Butterfield, 1994, Beta-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: implications to Alzheimer's disease, Biochem. Biophys. Res. Commun., 200, 710, 10.1006/bbrc.1994.1508

Cakir, 2001, Synthesis, spectroscopic and voltammetric studies of mixed-ligand copper(II) complexes of amino acids, Trans. Met. Chem., 26, 89, 10.1023/A:1007119907894

Chen, 2003, Zinc toxicity on neonatal cortical neurons: involvement of glutathione chelation, J. Neurochem., 85, 443, 10.1046/j.1471-4159.2003.01691.x

Chen, 1989, The effect of aging on glutathione and cysteine levels in different regions of the mouse brain, Proc. Soc. Exp. Biol. Med., 190, 399, 10.3181/00379727-190-42879

Chen, 2007, Study on the stability of resveratrol in rhizoma polygoni cuspidati, Zhong Yao Cai, 30, 805

Cherny, 2001, Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice, Neuron, 30, 665, 10.1016/S0896-6273(01)00317-8

Chishti, 2001, Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695, J. Biol. Chem., 276, 21562, 10.1074/jbc.M100710200

Conte, 2003, Synergistic protection of PC12 cells from beta-amyloid toxicity by resveratrol and catechin, Brain Res. Bull., 62, 29, 10.1016/j.brainresbull.2003.08.001

Dasgupta, 2007, Resveratrol stimulates AMP kinase activity in neurons, Proc. Natl. Acad. Sci. U.S.A., 104, 7217, 10.1073/pnas.0610068104

Engelhart, 2002, Dietary intake of antioxidants and risk of Alzheimer disease, J. Am. Med. Assoc., 287, 3223, 10.1001/jama.287.24.3223

Frankel, 1993, Inhibition of human LDL oxidation by resveratrol, Lancet, 341, 1103, 10.1016/0140-6736(93)92472-6

Fremont, 1999, Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids, Life Sci., 64, 2511, 10.1016/S0024-3205(99)00209-X

Gibson, 2000, Mitochondrial damage in Alzheimer's disease varies with apolipoprotein E genotype, Ann. Neurol., 48, 297, 10.1002/1531-8249(200009)48:3<297::AID-ANA3>3.0.CO;2-Z

Gibson, 2005, The alpha-ketoglutarate-dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration, Mol. Neurobiol., 31, 43, 10.1385/MN:31:1-3:043

Hallman, 1971, The computed distribution of copper(II) and zinc(II) ions among seventeen amino acids present in human blood plasma, Biochem. J., 121, 549, 10.1042/bj1210549

Hensley, 1994, A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease, Proc. Natl. Acad. Sci. U.S.A., 91, 3270, 10.1073/pnas.91.8.3270

Huang, 1999, Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction, J. Biol. Chem., 274, 37111, 10.1074/jbc.274.52.37111

Jang, 2003, Protective effect of resveratrol on beta-amyloid-induced oxidative PC12 cell death, Free Radical Biology & Medicine, 34, 1100, 10.1016/S0891-5849(03)00062-5

Juan, 1999, Determination of trans-resveratrol in plasma by HPLC, Anal. Chem., 71, 747, 10.1021/ac9808831

Karuppagounder, 2007, Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism, Neurobiol. Dis., 26, 353, 10.1016/j.nbd.2007.01.011

Karuppagounder, S.S., Xu, H., Shi, Q., Chen, L.H., Pedrini, S., Pechman, D.P., Baker, H.A., Beal, M.F., Gandy, S.E., Gibson, G.E., 2008. Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model. Neurobiol. Aging, doi: 10.1016/j.neurobiolaging.2007.12.013.

Kim, 2007, SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis, EMBO J., 26, 3169, 10.1038/sj.emboj.7601758

Kim, 2007, Protective effects of piceatannol against beta-amyloid-induced neuronal cell death, Ann. N. Y. Acad. Sci., 1095, 473, 10.1196/annals.1397.051

Kuhnle, 2000, Resveratrol is absorbed in the small intestine as resveratrol glucuronide, Biochem. Biophys. Res. Commun., 272, 212, 10.1006/bbrc.2000.2750

Lagouge, 2006, Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha, Cell, 127, 1109, 10.1016/j.cell.2006.11.013

Lakritz, 1997, Validated high-performance liquid chromatography–electrochemical method for determination of glutathione and glutathione disulfide in small tissue samples, Anal. Biochem., 247, 63, 10.1006/abio.1997.2032

Li, 1955, Some metal complexes of sulfur containing amino acids, J. Am. Chem. Soc., 77, 5225, 10.1021/ja01625a006

Li, 2004, Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice, J. Neurochem., 89, 1308, 10.1111/j.1471-4159.2004.02455.x

Li, 2006, Upregulation of endogenous antioxidants and phase 2 enzymes by the red wine polyphenol, resveratrol in cultured aortic smooth muscle cells leads to cytoprotection against oxidative and electrophilic stress, Pharmacol. Res., 53, 6, 10.1016/j.phrs.2005.08.002

Marambaud, 2005, Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides, J. Biol. Chem., 280, 37377, 10.1074/jbc.M508246200

Mark, 1997, A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide, J. Neurochem., 68, 255, 10.1046/j.1471-4159.1997.68010255.x

Miller, 1995, Antioxidant activity of resveratrol in red wine, Clin. Chem., 41, 1789, 10.1093/clinchem/41.12.1789

Morris, 2002, Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study, J. Am. Med. Assoc., 287, 3230, 10.1001/jama.287.24.3230

Nathan, 2005, Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase, J. Exp. Med., 202, 1163, 10.1084/jem.20051529

Nourooz-Zadeh, 1999, F4-isoprostanes as specific marker of docosahexaenoic acid peroxidation in Alzheimer's disease, J. Neurochem., 72, 734, 10.1046/j.1471-4159.1999.0720734.x

Ojaimi, 1999, Mitochondrial respiratory chain activity in the human brain as a function of age, Mech. Ageing Dev., 111, 39, 10.1016/S0047-6374(99)00071-8

Olivieri, 2001, N-acetyl-L-cysteine protects SHSY5Y neuroblastoma cells from oxidative stress and cell cytotoxicity: effects on beta-amyloid secretion and tau phosphorylation, J. Neurochem., 76, 224, 10.1046/j.1471-4159.2001.00090.x

Pappolla, 1998, Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo, Am. J. Pathol., 152, 871

Pinto, 2005, Treatment of YAC128 mice and their wild-type littermates with cystamine does not lead to its accumulation in plasma or brain: implications for the treatment of Huntington disease, J. Neurochem., 94, 1087, 10.1111/j.1471-4159.2005.03255.x

Pratico, 2002, Alzheimer's disease and oxygen radicals: new insights, Biochem. Pharmacol., 63, 563, 10.1016/S0006-2952(01)00919-4

Pratico, 2000, Increased 8,12-iso-iPF2alpha-VI in Alzheimer's disease: correlation of a noninvasive index of lipid peroxidation with disease severity, Ann. Neurol., 48, 809, 10.1002/1531-8249(200011)48:5<809::AID-ANA19>3.0.CO;2-9

Prokop, 2006, Resveratrol and its glycon piceid are stable polyphenols, J. Med. Food, 9, 11, 10.1089/jmf.2006.9.11

Ramassamy, 2000, Oxidative insults are associated with apolipoprotein E genotype in Alzheimer's disease brain, Neurobiol. Dis., 7, 23, 10.1006/nbdi.1999.0273

Robb, 2008, Molecular mechanisms of oxidative stress resistance induced by resveratrol: Specific and progressive induction of MnSOD, Biochem. Biophys. Res. Commun., 367, 406, 10.1016/j.bbrc.2007.12.138

Sale, 2005, Comparison of the effects of the chemopreventive agent resveratrol and its synthetic analog trans 3,4,5,4′-tetramethoxystilbene (DMU-212) on adenoma development in the Apc(Min+) mouse and cyclooxygenase-2 in human-derived colon cancer cells, Int. J. Cancer, 115, 194, 10.1002/ijc.20884

Sano, 1997, A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study, N. Engl. J. Med., 336, 1216, 10.1056/NEJM199704243361704

Smith, 1991, Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease, Proc. Natl. Acad. Sci. U.S.A., 88, 10540, 10.1073/pnas.88.23.10540

Smith, 1996, Oxidative damage in Alzheimer's, Nature, 382, 120, 10.1038/382120b0

Studer, 2001, N-Acetyl-L-cystein downregulates beta-amyloid precursor protein gene transcription in human neuroblastoma cells, Biogerontology, 2, 55, 10.1023/A:1010065103073

Wang, 2002, Resveratrol protects against global cerebral ischemic injury in gerbils, Brain Res., 958, 439, 10.1016/S0006-8993(02)03543-6

Wilson, 1996, Resveratrol promotes atherosclerosis in hypercholesterolemic rabbits, Life Sci., 59, 15, 10.1016/0024-3205(96)00260-3