Dietary polyphenols: Focus on resveratrol, a promising agent in the prevention of cardiovascular diseases and control of glucose homeostasis

Dixon, 2001, Natural products and plant disease resistance, Nature, 411, 843, 10.1038/35081178

Langcake, 1977, A new class of phytoalexins from grapevines, Experentia, 33, 151, 10.1007/BF02124034

Roggero, 1995, Effects of ultraviolet irradiation on resveratrol and changes in resveratrol and various of its derivatives in the skins of ripening grapes, Sci Aliments, 15, 411

Sbaghi, 1995, Development of methods using phytoalexin (resveratrol) assessment as a selection criterion to screen grapevine in vitro cultures for resistance to grey mould (Botrytis cinerea), Euphytica, 86, 41, 10.1007/BF00035937

Jang, 1997, Cancer chemopreventive activity of resveratrol, a natural product derived from grapes, Science, 275, 218, 10.1126/science.275.5297.218

Cucciolla, 2007, Resveratrol: from basic science to the clinic, Cell Cycle, 6, 2495, 10.4161/cc.6.20.4815

Baur, 2006, Therapeutic potential of resveratrol: the in vivo evidence, Nat Rev Drug Discov, 5, 493, 10.1038/nrd2060

Pezzuto, 2006, Resveratrol as an inhibitor of cancerogenesis, 233

Kaeberlein, 2005, Substrate-specific activation of sirtuins by resveratrol, J Biol Chem, 280, 17038, 10.1074/jbc.M500655200

Borra, 2005, Mechanism of human SIRT1 activation by resveratrol, J Biol Chem, 280, 17187, 10.1074/jbc.M501250200

Renaud, 1992, Wine, alcohol, platelets, and the French paradox for coronary heart disease, Lancet, 339, 1523, 10.1016/0140-6736(92)91277-F

Grønbæk, 2009, The positive and negative health effects of alcohol- and the public health implications, J Intern Med, 265, 407, 10.1111/j.1365-2796.2009.02082.x

Ray, 1999, The red wine antioxidant resveratrol protects isolated rat hearts from ischemia reperfusion injury, Free Radic Biol Med, 27, 160, 10.1016/S0891-5849(99)00063-5

Frankel, 1993, Inhibition of human LDL oxidation by resveratrol, Lancet, 341, 1103, 10.1016/0140-6736(93)92472-6

Fanì, 2008, Beneficial effects of resveratrol on atherosclerosis, J Med Food, 11, 610, 10.1089/jmf.2007.0091

Urpí-Sardà, 2005, Uptake of diet resveratrol into the human low-density lipoprotein. Identification and quantification of resveratrol metabolites by liquid chromatography coupled with tandem mass spectrometry, Anal Chem, 77, 3149, 10.1021/ac0484272

Sevov, 2006, Resveratrol regulates the expression of LXR-alpha in human macrophages, Biochem Biophys Res Commun, 348, 1047, 10.1016/j.bbrc.2006.07.155

Wang, 2002, Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivo and in vitro, Int J Mol Med, 9, 77

Szewczuk, 2004, Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2, J Biol Chem, 279, 22727, 10.1074/jbc.M314302200

Shen, 2007, Inhibitory mechanisms of resveratrol in platelet activation: pivotal roles of p38 MAPK and NO/cyclic GMP, Br J Haematol, 139, 475, 10.1111/j.1365-2141.2007.06788.x

Naderali, 2000, Resveratrol induces vasorelaxation of mesenteric and uterine arteries from female guinea-pigs, Clin Sci (London), 98, 537, 10.1042/CS19990303

Kinlay, 2001, Endothelial function and coronary artery disease, Curr Opin Lipidol, 12, 383, 10.1097/00041433-200108000-00003

Davignon, 2004, Role of endothelial dysfunction in atherosclerosis, Circulation, 109, III27, 10.1161/01.CIR.0000131515.03336.f8

Orallo, 2002, The possible implication of trans-resveratrol in the cardioprotective effects of long-term moderate wine consumption, Mol Pharmacol, 61, 294, 10.1124/mol.61.2.294

Das, 2005, Coordinated induction of iNOS-VEGF-KDR-eNOS after resveratrol consumption: a potential mechanism for resveratrol preconditioning of the heart, Vascul Pharmacol, 42, 281, 10.1016/j.vph.2005.02.013

Liu, 2003, Inhibition of cyclic strain-induced endothelin-1 gene expression by resveratrol, Hypertension, 42, 1198, 10.1161/01.HYP.0000103162.76220.51

Shigematsu, 2003, Resveratrol, a red wine constituent polyphenol, prevents superoxide-dependent inflammatory responses induced by ischemia/reperfusion, platelet-activating factor, or oxidants, Free Radic Biol Med, 34, 810, 10.1016/S0891-5849(02)01430-2

Ferrero, 1998, Activity in vitro of resveratrol on granulocyte and monocyte adhesion to endothelium, Am J Clin Nutr, 68, 208, 10.1093/ajcn/68.6.1208

Manna, 2000, Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation, J Immunol, 164, 6509, 10.4049/jimmunol.164.12.6509

Lekli, 2008, Protective mechanisms of resveratrol against ischemia-reperfusion-induced damage in hearts obtained from Zucker obese rats: the role of GLUT-4 and endothelin, Am J Physiol Heart Circ Physiol, 294, H859, 10.1152/ajpheart.01048.2007

Thirunavukkarasu, 2007, Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes: role of nitric oxide, thioredoxin, and heme oxygenase, Free Radic Biol Med, 43, 720, 10.1016/j.freeradbiomed.2007.05.004

Brakenhielm, 2001, Suppression of angiogenesis, tumor growth, and wound healing by resveratrol, a natural compound in red wine and grapes, FASEB J, 15, 1798, 10.1096/fj.01-0028fje

Csiszar, 2009, Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells, Am J Physiol Heart Circ Physiol, 297, H1876, 10.1152/ajpheart.00375.2009

Das, 2006, Protective effects of resveratrol against ischemia-reperfusion, 519

Hattori, 2002, Pharmacological preconditioning with resveratrol: role of nitric oxide, Am J Physiol Heart Circ Physiol, 282, H1988, 10.1152/ajpheart.01012.2001

Lagouge, 2006, Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1 alpha, Cell, 127, 1109, 10.1016/j.cell.2006.11.013

Baur, 2006, Resveratrol improves health and survival of mice on a high-calorie diet, Nature, 444, 337, 10.1038/nature05354

Cantó, 2009, AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity, Nature, 458, 1056, 10.1038/nature07813

Barger, 2008, A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice, PLoS One, 6, 2264, 10.1371/journal.pone.0002264

Crowell, 2004, Resveratrol-associated renal toxicity, Toxicol Sci, 82, 614, 10.1093/toxsci/kfh263

Almeida, 2009, Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers, Mol Nutr Food Res, 53, S7, 10.1002/mnfr.200800177

Walle, 2004, High absorption but very low bioavailability of oral resveratrol in humans, Drug Metab Dispos, 32, 1377, 10.1124/dmd.104.000885

Soleas, 2001, Measurement of trans-resveratrol, (1)-catechin, and quercetin in rat and human blood and urine by gas chromatography with mass selective detection, Meth Enzymol, 335, 130, 10.1016/S0076-6879(01)35238-2

Soleas, 2001, Ultrasensitive assay for three polyphenols (catechin, quercetin and resveratrol) and their conjugates in biological fluids utilizing gas chromatography with mass selective detection, J Chromatogr B Biomed Sci Appl, 757, 161, 10.1016/S0378-4347(01)00142-6

Boocock, 2007, Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent, Cancer Epidemiol Biomarkers Prev, 16, 1246, 10.1158/1055-9965.EPI-07-0022