Dietary conjugated linoleic acids promote fatty streak formation in the C57BL/6 mouse atherosclerosis model

British Journal of Nutrition - Tập 81 Số 3 - Trang 251-255 - 1999
John S. Munday1, K.G. Thompson1, K. A. C. James2
1Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand
2New Zealand Institute for Crop and Food Research Limited, Palmerston North, New Zealand

Tóm tắt

Conjugated linoleic acids (CLA) are positional isomers of linoleic acid which have been suggested by some to possess antiatherosclerotic properties. To test this hypothesis, three groups of twenty C57BL/6 mice were fed on atherogenic diets containing: 5 g CLA/kg, 2·5 g CLA + 2·5 g linoleic acid/kg or 5 g linoleic acid/kg. All diets were fed for 15 weeks and contained (g/kg): triacylglycerol 145, free fatty acids 5, cholesterol 10 and cholic acid 5. At the completion of the experimental period, when data from both groups fed on CLA were combined, dietary CLA did not produce significant differences in body weight, serum total cholesterol concentration or serum HDL-cholesterol concentration. However, mice receiving CLA developed a significantly higher serum HDL-cholesterol: total cholesterol ratio and a significantly lower serum triacylglycerol concentration than controls. Despite causing a serum lipoprotein profile considered to be less atherogenic, the addition of CLA to the atherogenic diet increased the development of aortic fatty streaks. Considering the increased atherogenesis associated with dietary CLA in the present study, and the failure to demonstrate a significant beneficial effect of CLA in other animal studies, there is currently no conclusive evidence to support the hypothesis that CLA protect against atherogenesis.

Từ khóa


Tài liệu tham khảo

Nishina, 1993, Effects of dietary fats from animal and plant sources on diet-induced fatty streak lesions in C57BL/6J mice, Journal of Lipid Research, 34, 1413, 10.1016/S0022-2275(20)36970-4

10.1016/0002-9149(91)90094-2

10.1006/bbrc.1994.1157

10.1007/s11745-997-0025-0

Ha, 1990, Inhibition of benz(a)pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid, Cancer Research, 50, 1097

10.3382/ps.0721301

10.1161/01.ATV.18.1.114

10.1016/0021-9150(87)90249-8

Ip, 1991, Mammary cancer prevention by conjugated dienoic derivative of linoleic acid, Cancer Research, 51, 6118

10.1093/jn/127.6.1055

1995, Nutrient Requirements of Laboratory Animals

10.1007/BF02536996

Breslow, 1996, Atherosclerosis and Coronary Artery Disease, 363

10.1056/NEJM199108083250601

10.1161/01.ATV.15.5.551

Nishina, 1990, Synthetic low and high fat diets for the study of atherosclerosis in the mouse, Journal of Lipid Research, 31, 859, 10.1016/S0022-2275(20)42785-3

10.1016/0021-9150(87)90202-4

Haumann, 1996, Conjugated linoleic acid, International News on Fats, Oils and Related Materials, 7, 152

Nicolosi, 1997, Dietary conjugated linoleic acid reduces plasma lipoproteins and early atherosclerosis in hypercholesterolemic hamsters, Artery, 22, 266

10.1016/0021-9150(91)90117-L

10.1016/0021-9150(94)90034-5

10.1016/0889-1575(92)90037-K

10.1161/01.CIR.90.4.2126

Wong, 1997, Effects of dietary conjugated linoleic acid on lymphocyte function and growth of mammary tumors in mice, Anticancer Research, 17, 987

Aviram, 1996, Interaction of oxidised low density lipoprotein with macrophages in atherosclerosis, and the antiatherogenicity of antioxidants, European Journal of Clinical Chemistry and Clinical Biochemistry, 34, 599

10.1007/s11745-997-0109-x

Izzo, 1981, Improved method for determination of high-density-lipoprotein cholesterol I. Isolation of high-density lipoproteins by use of polyethylene glycol 6000, Clinical Chemistry, 27, 371, 10.1093/clinchem/27.3.371

Thông tin
Thông tin xuất bản

British Journal of Nutrition

Tập 81 Số 3

251-255

Thông tin tác giả