Dietary choline and betaine intakes and risk of total and lethal prostate cancer in the Atherosclerosis Risk in Communities (ARIC) Study

Cancer Causes & Control - Tập 30 - Trang 343-354 - 2019
Peijin Han1, Aurelian Bidulescu2, John R. Barber1, Steven H. Zeisel3, Corinne E. Joshu1,4, Anna E. Prizment5, Mara Z. Vitolins6, Elizabeth A. Platz1,4,7,8
1Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA;
2Department of Epidemiology and Biostatistics, Indiana University Bloomington School of Public Health, Bloomington, USA
3Nutrition Research Institute, University of North Carolina at Chapel Hill, Chapel Hill, USA
4Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, USA
5Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, USA
6Epidemiology & Prevention Office of Women in Medicine and Science Center on Diabetes, Obesity, and Metabolism, Wake Forest School of Medicine, Winston-Salem, USA
7Department of Urology and the James Buchanan Brady Urologic Institute, Johns Hopkins University School of Medicine, Baltimore, USA
8Baltimore, USA

Tóm tắt

Two prior cohort studies suggested that choline, but not betaine intake, is associated with an increased risk of advanced prostate cancer (PCa). Given that evidence remains limited, we evaluated whether intakes of choline and derivative betaine are associated with total and lethal PCa risk and PCa death in men with PCa. We included 6,528 men (24.4% African American) without a cancer diagnosis at baseline (1987–1989) followed through 2012. Dietary intake was assessed using a food frequency questionnaire coupled with a nutrient database. We used Cox proportional hazards regression to estimate hazards ratios (HRs) and 95% confidence intervals (CIs) of total and lethal PCa risk overall and by race. Choline intake was not associated with total (n = 811) or lethal (n = 95) PCa risk overall or by race. Betaine intake was inversely associated with lethal (tertile 3 vs 1, HR 0.59, 95% CI 0.35–1.00, p trend = 0.04), but not total PCa risk; patterns for lethal PCa were similar by race. Neither nutrient was associated with PCa death in men with PCa. Choline intake was not associated with total or lethal PCa or with PCa death in men with PCa. Betaine intake was inversely associated with lethal, but not total PCa risk or with PCa death in men with PCa. Our results do not support the hypothesis that higher choline intake increases lethal PCa risk, but do suggest that higher betaine intake may be associated with lower lethal PCa risk. Further investigation with a larger number of lethal cases is needed.

Tài liệu tham khảo

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Cancer Causes & Control

Tập 30

343-354

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