Dietary cadmium (Cd) reduces hemocyte level by induction of apoptosis in Drosophila melanogaster

Abrams, 1993, Programmed cell death during drosophila embryogenesis, Development, 117, 29, 10.1242/dev.117.1.29 Banakou, 2010, Involvement of Na /H+ exchanger and respiratory burst enzymes NDPH oxidase and NO synthase, in Cd-induced lipid peroxidation and DNA damage in haemocytes of mussels, Comp. Biochem. Physiol., Part C: Toxicol. Pharmacol., 152, 346 Banerjee, 2019, Drosophila as a genetic model for hematopoiesis, Genetics, 211, 367, 10.1534/genetics.118.300223 Bertin, 2006, Cadmium: cellular effects, modifications of biomolecules, modulation of DNA repair and genotoxic consequences (a review), Biochimie, 88, 1549, 10.1016/j.biochi.2006.10.001 Borowska, 2011, Effects of heavy metals on insect immunocompetent cells, J. Insect Physiol., 57, 760, 10.1016/j.jinsphys.2011.02.012 Cao, 2018, The impact of ocean acidification and cadmium on the immune responses of Pacific oyster, Crassostrea gigas, Fish Shellfish Immunol., 456, 10.1016/j.fsi.2018.07.055 Denton, 2015, Using the vital dye acridine orange to detect dying cells in drosophila, Cold Spring Harb Protoc, 2015, 572, 10.1101/pdb.prot086207 Dudzic, 2015, Drosophila innate immunity: regional and functional specialization of prophenoloxidases, BMC Biol., 13, 81, 10.1186/s12915-015-0193-6 Ebrahimi, 2020, Effects of lead and cadmium on the immune system and cancer progression, J. Environ. Health Sci. Eng., 18, 335, 10.1007/s40201-020-00455-2 Egli, 2006, A family knockout of all four drosophila metallothioneins reveals a central role in copper homeostasis and detoxification, Mol. Cell. Biol., 26, 2286, 10.1128/MCB.26.6.2286-2296.2006 Egorova, 2017, Toxicity of metal compounds: knowledge and myths, Organometallics, 36, 4071, 10.1021/acs.organomet.7b00605 Filipic, 2012, Mechanisms of cadmium induced genomic instability, Mutat. Res., 733, 69, 10.1016/j.mrfmmm.2011.09.002 Goto, 2003, Drosophila hemolectin gene is expressed in embryonic and larval hemocytes and its knock down causes bleeding defects, Dev. Biol., 264, 582e591, 10.1016/j.ydbio.2003.06.001 Hillyer, 2016, Insect immunology and hematopoiesis, Dev. Comp. Immunol., 58, 102, 10.1016/j.dci.2015.12.006 Hu, 2019, Effects of cadmium on fecundity and defence ability of Drosophila melanogaster, Ecotoxicol. Environ. Saf., 171, 871, 10.1016/j.ecoenv.2019.01.029 Huang, 2005, The lesswright mutation activates rel-related proteins, leading to overproduction of larval hemocytes in Drosophila melanogaster, Dev. Biol., 280, 407, 10.1016/j.ydbio.2005.02.006 Joly, 2017, Functional and molecular responses of the blue mussel Mytilus edulis' hemocytes exposed to cadmium - an in vitro model and transcriptomic approach, Fish Shellfish Immunol., 67, 575, 10.1016/j.fsi.2017.06.001 Krzemien, 2007, Control of blood cell homeostasis in drosophila larvae by the posterior signalling Centre, Nature, 446, 325, 10.1038/nature05650 Leitão, 2015, Drosophila sessile hemocyte clusters are true hematopoietic tissues that regulate larval blood cell differentiation, elife, 4, 10.7554/eLife.06166 Luo, 1995, An amino acid substitution in the drosophila hopTum–l jak kinase causes leukemia-like hematopoietic defects, EMBO J., 14, 1412, 10.1002/j.1460-2075.1995.tb07127.x Marigómez, 2002, Cellular and subcellular distribution of metals in molluscs, Microsc. Res. Tech., 56, 358, 10.1002/jemt.10040 Márkus, 2009, Sessile hemocytes as a hematopoietic compartment in drosophila melanogaster, Proc. Natl. Acad. Sci. U. S. A., 106, 4805, 10.1073/pnas.0801766106 Nanda, 2019, Chronic lead (Pb) exposure results in diminished hemocyte count and increased susceptibility to bacterial infection in Drosophila melanogaster, Chemosphere, 236, 10.1016/j.chemosphere.2019.124349 Nigam, 1999, Glutathione depletion and oxidative damage in mitochondria following exposure to cadmium in rat liver and kidney, Toxicol. Lett., 106, 151, 10.1016/S0378-4274(99)00059-4 Olakkaran, 2018, Lead modulated heme synthesis inducing oxidative stress mediated genotoxicity in Drosophila melanogaster, Sci. Total Environ., 634, 628, 10.1016/j.scitotenv.2018.04.004 Petraki, 2015, Assaying blood cell populations of the Drosophila melanogaster larva, J. Vis. Exp., 105, 52733 Qiu, 1998, A role for the drosophila Toll/cactus pathway in larval hematopoiesis, Development, 125, 1509, 10.1242/dev.125.10.1909 Qiu, 2020, Transcriptomic profile of oyster Crassostrea gigas hemocyte after short-term cadmium exposure and bacteria stimulation, Fish Shellfish Immunol., 98, 138, 10.1016/j.fsi.2019.12.083 Ramond, 2019 Rani, 2014, Cellular mechanisms of cadmium-induced toxicity: a review, Int. J. Environ. Health Res., 24, 378, 10.1080/09603123.2013.835032 Rizki, 1980, A mutant affecting the crystal cells in Drosophila melanogaster, Wilhelm Roux. Arch. Dev. Biol., 188, 91, 10.1007/BF00848799 Robinson, 1988, Transport of cadmium and other metals in the blood of the bivalve mollusk Mercenaria mercenaria, Mar. Biol., 97, 101, 10.1007/BF00391250 Sarkissian, 2014, Detecting apoptosis in drosophila tissues and cells, Methods, 68, 89, 10.1016/j.ymeth.2014.02.033 Sokolova, 2004, Cadmium- induced apoptosis in oyster hemocytes involves disturbance of cellular energy balance but no mitochondrial permeability transition, J. Exp. Biol., 207, 3369, 10.1242/jeb.01152 Stalmach, 2015, DNA damage in haemocytes and midgut gland cells of Steatoda grossa (Theridiidae) spiders exposed to food contaminated with cadmium, Ecotoxicol. Environ. Saf., 113, 353, 10.1016/j.ecoenv.2014.12.023 Tang, 2009, Regulation and function of the melanization reaction in drosophila, Fly (Austin), 3, 105, 10.4161/fly.3.1.7747 Waisberg, 2003, Molecular and cellular mechanisms of cadmium carcinogenesis, Toxicology, 192, 95, 10.1016/S0300-483X(03)00305-6 Wilczek, 2018, Effects of food contaminated with cadmium and copper on hemocytes of Steatoda grossa (Araneae: Theridiidae), Ecotoxicol. Environ. Saf., 149, 267, 10.1016/j.ecoenv.2017.12.007 Wu, 2016, A review of toxicity and mechanisms of individual and mixtures of heavy metals in the environment, Environ. Sci. Pollut. Res. Int., 23, 8244, 10.1007/s11356-016-6333-x Yang, 2020, Multigenerational effects of cadmium on the lifespan and fertility of Drosophila melanogaster, Chemosphere, 245, 10.1016/j.chemosphere.2019.125533 Zhang, 2016, Cadmium modulates hematopoietic stem and progenitor cells and skews toward myelopoiesis in mice, Toxicol. Appl. Pharmacol., 313, 24, 10.1016/j.taap.2016.10.016