Dietary Supplementation With Medium-Chain Triglycerides Reduces Candida Gastrointestinal Colonization in Preterm Infants

Pediatric Infectious Disease Journal - Tập 38 Số 2 - Trang 164-168 - 2019
Amanda B. Arsenault1,2, Kearney T. W. Gunsalus3,4, Sonia S. Laforce‐Nesbitt1,2, Lynn Przystac1, Erik J. DeAngelis1, Michaela E. Hurley1, Ethan S. Vorel2, Richard Tucker1, Nirupa R. Matthan5, Alice H. Lichtenstein5, Carol A. Kumamoto4, Joseph M. Bliss1,2
1Department of Pediatrics, Women & Infants Hospital of Rhode Island
2Warren Alpert Medical School of Brown University, Providence, Rhode Island
3Department of Biology, Siena College, Loudonville, New York
4Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts
5Cardiovascular Nutrition Laboratory, JM USDA Human Nutrition Research Center, Tufts University, Boston, Massachusetts.

Tóm tắt

Background:

Candida is an important cause of infections in premature infants. Gastrointestinal colonization with Candida is a common site of entry for disseminated disease. The objective of this study was to determine whether a dietary supplement of medium-chain triglycerides (MCTs) reduces Candida colonization in preterm infants.

 Methods:

Preterm infants with Candida colonization (n = 12) receiving enteral feedings of either infant formula (n = 5) or breast milk (n = 7) were randomized to MCT supplementation (n = 8) or no supplementation (n = 4). Daily stool samples were collected to determine fungal burden during a 3-week study period. Infants in the MCT group received supplementation during 1 week of the study period. The primary outcome was fungal burden during the supplementation period as compared with the periods before and after supplementation.

 Results:

Supplementation of MCT led to a marked increase in MCT intake relative to unsupplemented breast milk or formula as measured by capric acid content. In the treatment group, there was a significant reduction in fungal burden during the supplementation period as compared with the period before supplementation (rate ratio, 0.15; P = 0.02), with a significant increase after supplementation was stopped (rate ratio, 61; P < 0.001). Fungal burden in the control group did not show similar changes.

 Conclusions:

Dietary supplementation with MCT may be an effective method to reduce Candida colonization in preterm infants.

Từ khóa


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Thông tin xuất bản

Pediatric Infectious Disease Journal

Tập 38 Số 2

164-168

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