Holler N, et al. (2000) Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat. Immunol. 1:489–95.
Matsumura H, et al. (2000) Necrotic death pathway in Fas receptor signaling. J. Cell Biol. 151:1247–56.
Schulze-Osthoff K, Krammer PH, Droge W. (1994) Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death. EMBO J. 13:4587–96.
Vercammen D, et al. (1998) Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor. J. Exp. Med. 187:1477–85.
Hotchkiss RS, Nicholson DW. (2006) Apoptosis and caspases regulate death and inflammation in sepsis. Nat. Rev. Immunol. 6:813–22.
Hotchkiss RS, Strasser A, McDunn JE, Swanson PE. (2009) Cell death. N. Engl. J. Med. 361:1570–83.
Gerlach B, et al. (2011) Linear ubiquitination prevents inflammation and regulates immune signalling. Nature. 471:591–596.
Haas TL, et al. (2009) Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. Mol. Cell. 36:831–44.
Krammer PH, Arnold R, Lavrik IN. (2007) Life and death in peripheral T cells. Nat. Rev. Immunol. 7:532–42.
Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G. (2010) Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat. Rev. Mol. Cell Biol. 11:700–14.
Challa S, Chan FK. (2010) Going up in flames: necrotic cell injury and inflammatory diseases. Cell Mol. Life Sci.
Christofferson DE, Yuan J. (2010) Necroptosis as an alternative form of programmed cell death. Curr. Opin. Cell Biol. 22:263–8.
Declercq W, Vanden Berghe T, Vandenabeele P. (2009) RIP kinases at the crossroads of cell death and survival. Cell. 138:229–32.
Oberst A, et al. (2011) Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature. 471:363–7.
Galluzzi L, et al. (2011) Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death. Differ. 19:107–20.
He S, et al. (2009) Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell 137:1100–11.
Vandenabeele P, Vanden Berghe T, Festjens N. (2006) Caspase inhibitors promote alternative cell death pathways. Sci. STKE. 2006:e44.
Cho YS, et al. (2009) Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell. 137:1112–23.
Ch’en IL, et al. (2008) Antigen-mediated T cell expansion regulated by parallel pathways of death. Proc. Natl. Acad. Sci. U.S.A 105:17463–8.
Trichonas G, et al. (2010) Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis. Proc. Natl. Acad. Sci. U.S.A. 107:21695–700.
Northington FJ, et al. (2011) Necrostatin decreases oxidative damage, inflammation, and injury after neonatal HI. J. Cereb. Blood Flow Metab. 31:178–89.
Smith CC, et al. (2007) Necrostatin: a potentially novel cardioprotective agent? Cardiovasc. Drugs Ther. 21:227–33.
Linkermann A et al. (2012) Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury. Kidney Int. 81:751–61.
Kaiser WJ, et al. (2011) RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature. 471:368–72.
Zhang DW, et al. (2009) RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science. 325:332–6.
Biton S, Ashkenazi A. (2011) NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-alpha feedforward signaling. Cell. 145:92–103.
Degterev A, et al. (2008) Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat. Chem. Biol. 4:313–21.
Cauwels A, Janssen B, Waeytens A, Cuvelier C, Brouckaert P. (2003) Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2. Nat. Immunol. 4:387–93.
Upton JW, Kaiser WJ, Mocarski ES. (2010) Virus inhibition of RIP3-dependent necrosis. Cell Host. Microbe 7:302–13.
Zhang DW, et al. (2011). Multiple death pathways in TNF-treated fibroblasts. Cell Res. 2011. 21:368–71.
Garcia-Calvo M, et al. (1998) Inhibition of human caspases by peptide-based and macromolecular inhibitors. J. Biol. Chem. 273:32608–13.
Krautwald S, et al. (2010) Effective blockage of both the extrinsic and intrinsic pathways of apoptosis in mice by TAT-crmA. J. Biol. Chem. 285:19997–20005.
Christofferson DE, Yuan J. (2010) Cyclophilin A release as a biomarker of necrotic cell death. Cell Death. Differ. 17:1942–3.
Newton K, Sun X, Dixit VM. (2004). Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4. Mol. Cell Biol. 24:1464–9.
Chen Y, et al. (2010). Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy. Proc. Natl. Acad. Sci. U.S.A. 107:9035–42.
Sawai H, Domae N. (2011) Discrimination between primary necrosis and apoptosis by necrostatin-1 in Annexin V-positive/propidium iodide-negative cells. Biochem. Biophys. Res. Commun. 411:569–73.
Wu YT, et al. (2011) zVAD-induced necroptosis in L929 cells depends on autocrine production of TNFalpha mediated by the PKC-MAPKs-AP-1 pathway. Cell Death Differ. 18:26–37.
Linkermann A, et al. (2011) Renal tubular Fas ligand mediates fratricide in cisplatin-induced acute kidney failure. Kidney Int. 79:169–78.
Callus BA, Vaux DL. (2007) Caspase inhibitors: viral, cellular and chemical. Cell Death.Differ. 14:73–8.
Gubser C, et al. (2007) A new inhibitor of apoptosis from vaccinia virus and eukaryotes. PLoS. Pathog. 3:e17.
Zhou Q, et al. (1997) Target protease specificity of the viral serpin CrmA. Analysis of five caspases. J. Biol. Chem. 272:7797–800.
Krautwald S, Ziegler E, Tiede K, Pust R, Kunzendorf U. (2004) Transduction of the TAT-FLIP fusion protein results in transient resistance to Fas-induced apoptosis in vivo. J. Biol. Chem. 279:44005–11.
Devalaraja-Narashimha K, Diener AM, Padanilam BJ. (2009) Cyclophilin D gene ablation protects mice from ischemic renal injury. Am. J. Physiol. Renal Physiol. 297:F749–59.
Cinel I, Opal SM. (2009) Molecular biology of inflammation and sepsis: a primer. Crit. Care Med. 37:291–304.
Hotchkiss RS, et al. (1999) Prevention of lymphocyte cell death in sepsis improves survival in mice. Proc. Natl. Acad. Sci. U.S.A. 96:14541–6.
Quan LT, Caputo A, Bleackley RC, Pickup DJ, Salvesen GS. (1995) Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A. J. Biol. Chem. 270:10377–9.
Duprez L, et al. (2011) RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome. Immunity. 35:908–18.
Degterev A, et al. (2005) Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat. Chem. Biol. 1:112–9.
Jagtap PG, et al. (2007) Structure-activity relationship study of tricyclic necroptosis inhibitors. J. Med. Chem. 50:1886–95.
Temkin V, Huang Q, Liu H, Osada H, Pope RM. (2006) Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis. Mol. Cell Biol. 26:2215–25.
Kung G, Konstantinidis K, Kitsis RN. (2011) Programmed necrosis, not apoptosis, in the heart. Circ. Res. 108:1017–1036.