Diagnostic specificity of autoantibodies to M-type phospholipase A2 receptor (PLA2R) in differentiating idiopathic membranous nephropathy (IMN) from secondary forms and other glomerular diseases

Couser WG (2017) Primary membranous nephropathy. Clin J Am Soc Nephrol; 12(6):983–997

Sinico RA, Mezzina N, Trezzi B, Ghiggeri GM, Radice A (2016) Immunology of membranous nephropathy: from animal models to humans. Clin Exp Immunol 183(2):157 – 65

Kerjaschki D (2000) Pathogenetic concepts of membranous glomerulopathy (MGN). J Nephrol 13:S96–S100

Beck LH, Bonegio RGB, Lambeau G, Beck DM, Powell DW, Cummins TD, Klein JB, Salant DJ (2009) M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med 361(1):11–21

Hoxha E, Harendza S, Zahner G, Panzer U, Steinmetz O, Fechner K, Helmchen U, Stahl RA (2011) An immunofluorescence test for phospholipase-A2-receptor antibodies and its clinical usefulness in patients with membranous glomerulonephritis. Nephrol Dial Transpl 26(8):2526–2532

Radice A, Trezzi B, Maggiore U, Pregnolato F, Stellato T, Napodano P, Rolla D, Pesce G, D’Amico M, Santoro D, Londrino F, Ravera F, Ortisi G, Sinico RA (2016) Clinical usefulness of autoantibodies to M-type phospholipase A2 receptor (PLA2R) for monitoring disease activity in idiopathic membranous nephropathy (IMN). Autoimmun Rev 15(2):146–154

Ruggenenti P, Debiec H, Ruggiero B, Chianca A, Pellé T, Gaspari F, Suardi F, Gagliardini E, Orisio S, Benigni A, Ronco P, Remuzzi G (2015) Anti-phospholipase A2 receptor antibody titer predicts post-rituximab outcome of membranous nephropathy. J Am Soc Nephrol 26:2545–2558

Dai H, Zhang H, He Y (2015) Diagnostic accuracy of PLA2R autoantibodies and glomerular staining for the differentiation of idiopathic and secondary membranous nephropathy: an updated meta-analysis. Sci Rep 5:8803. doi: 10.1038/srep08803

Ge YC, Jin B, Zeng CH, Zhang MC, Chen DC, Yin R, Le WB (2016) PLA2R antibodies and PLA2R glomerular deposits in psoriasis patients with membranous nephropathy. BMC Nephrol 22 17:185. doi: 10.1186/s12882-016-0407-3

Qin W, Beck LH, Zeng C, Chen Z, Li S, Zuo K, Salant DJ, Liu Z (2011) Anti-phospholipase A2 receptor antibody in membranous nephropathy. J Am Soc Nephrol 22:1137–1143

Hihara K, Iyoda M, Tachibana S, Iseri K, Saito T, Yamamoto Y, Suzuki T, Wada Y, Matsumoto K, Shibata T (2016). Anti-phospholipase A2 receptor (PLA2R) antibody and glomerular PLA2R expression in Japanese patients with membranous nephropathy. PLoS One 11(6):doi: 10.1371/journal.pone.0158154

Akiyama S, Akiyama M, Imai E, Ozaki T, Matsuo S, Maruyama S (2015) Prevalence of anti-phospholipase A2 receptor antibodies in Japanese patients with membranous nephropathy. Clin Exp Nephrol 19:653–660

Timmermans SA, Ayalon R, van Paassen P, Beck LH Jr, van Rie H, Wirtz JJ, Verseput GH, Frenken LA, Salant DJ, Cohen Tervaert JW; Limburg Renal Registry (2013). Anti-phospholipase A2 receptor antibodies and malignancy in membranous nephropathy. Am J Kidney Dis 62(6):1223–1225

Larsen CP, Messias NC, Silva FG, Messias E, Walker PD (2013) Determination of primary versus secondary membranous glomerulopathy utilizing phospholipase A2 receptor staining in renal biopsies. Modern Pathol 26:709–715

Xie Q, Li Y, Xue J, Xiong Z, Wang L, Sun Z, Ren Y, Zhu X, Hao CM (2015) Renal phospholipase A2 receptor in hepatitis B virus-associated membranous nephropathy. Am J Nephrol; 41:345–353

Li X, Wei D, Zhou Z, Wang B, Xu Y, Pan J, Yang C, Lu J, Qiu Y (2016) Anti-PLA2R antibodies in chinese patients with membranous nephropathy. Med Sci Monit 22:1630–1636

Kimura Y, Miura N, Debiec H, Morita H, Yamada H, Banno S, Ronco P, Imai H (2017) Circulating antibodies to α-enolase and phospholipase A2 receptor and composition of glomerular deposits in Japanese patients with primary or secondary membranous nephropathy. Clin Exp Nephrol 21:117–126

Hill PA, McRae JL, Dwyer KM (2016) PLA2R and membranous nephropathy: a 3 year prospective Australian study. Nephrology (Carlton) 21:397–403

Dauvergne M, Moktefi A, Rabant M, Vigneau C, Kofman T, Burtey S, Corpechot C, Stehlé T, Desvaux D, Rioux-Leclercq N, Rouvier P, Knebelmann B, Boffa JJ, Frouget T, Daugas E, Jablonski M, Dahan K, Brocheriou I, Remy P, Grimbert P, Lang P, Chazouilleres O, Sahali D, Audard V (2015) Membranous nephropathy associated with immunological disorder-Related liver disease. A retrospective study of 10 cases. Medicine (Baltimore) 94(30):e1243. doi: 10.1097/MD.0000000000001243

Stehlé T, Audard V, Ronco P, Debiec H (2015) Phospholipase A2 receptor and sarcoidosis-associated membranous nephropathy. Nephrol Dial Transpl 30:1047–1050

Oh YJ, Yang SH, Kim DK, Kang SW, Kim YS (2013). Autoantibodies against phospholipase A2 receptor in korean patients with membranous nephropathy. PLoS One 8(4):e62151.doi: 10.1371/journal.pone

Svobodova B, Honsova E, Ronco P, Tesar V, Debiec H (2013) Kidney biopsy is a sensitive tool for retrospective diagnosis of PLA2R-related membranous nephropathy. Nephrol Dial Transpl 28:1839–1844

Dähnrich C, Komorowski L, Probst C, Seitz-Polski B, Esnault V, Wetzels JF, Hofstra JM, Hoxha E, Stahl RA, Lambeau G, Stöcker W, Schlumberger W (2013) Development of a standardized ELISA for the determination of autoantibodies against human M-type phospholipase A2 receptor in primary membranous nephropathy. Clin Chim Acta 421:213–218

Gunnarsson I, Schlumberger W, Rönnelid J (2012) Antibodies to M-Type phospholipase A2 receptor (PLA2R) and membranous lupus nephritis. Am J Kidney Dis 59(4):585–586

Gopalakrishnan N, Abeesh P, Dineshkumar T, Murugananth S, Sakthirajan R, Raman GS, Dhanapriya J, Balasubramaniyan T, Haris M (2016). Prevalence of serum anti M-type phospholipase A2 receptor antibody in primary membranous nephropathy: a single center experience. Indian J Nephrol 26(4):257–261

Hu SL, Wang D, Gou WJ, Lei QF, Ma TA, Cheng JZ (2014) Diagnostic value of phospholipase A2 receptor in idiopathic membranous nephropathy: a systematic review and meta-analysis. J Nephrol 27(2):111–116

Cambier JF, Ronco P (2012) Onco-Nephrology: Glomerular Diseases with Cancer. Clin J Am Soc Nephrol; 7:1701–1712

Beck LH Jr (2010) Membranous nephropathy malignancy seminars Nephrol 30(6):635–644

Murtas C, Ghiggeri GM (2016). Membranous glomerulonephritis: histological and serological features to differentiate cancer-related and non-related forms. J Nephrol 29(4):469–478

Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RA (2016) A mechanism for cancer-associated membranous nephropathy. N Engl J Med 374(20):1995–1996

De Vriese AS, Glassock RJ, Nath KA, Sethi S, Fervenza FC (2017) A proposal for a serology-based approach to membranous nephropathy. J Am Soc Nephrol 28:421–430