Diabetes y enfermedad cardiovascular

Fuster, 2005, MDGs: chronic diseases are not on the agenda, Lancet, 366, 1512, 10.1016/S0140-6736(05)67610-6 Yusuf, 2001, Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization, Circulation, 104, 2746, 10.1161/hc4601.099487 Popkin, 1998, The nutrition transition and its health implications in lower-income countries, Public Health Nutr, 1, 5, 10.1079/PHN19980004 Amos, 1997, The rising global burden of diabetes and its complications: estimates and projections to the year 2010, Diabet Med, 14, S1 King, 1998, Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections, Diabetes Care, 21, 1414, 10.2337/diacare.21.9.1414 Harris, 1998, Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The Third National Health and Nutrition Examination Survey, 1988-1994, Diabetes Care, 21, 518, 10.2337/diacare.21.4.518 Escaned J, Ryden L, Zamorano JL, Poole-Wilson P, Fuster V, Gitt A, et al. Trends and contexts in European cardiology practice for the next 15 years: The Madrid Declaration: a report from the European Conference on the Future of Cardiology, Madrid, 2-3 June 2006. Eur Heart J. 2007;28:634-7. Simanis, 1987, Health care expenditures: international comparisons, 1970-80, Soc Secur Bull, 50, 19 1998, American Diabetes Association, Diabetes Care, 21, 296 Brown, 1999, The progressive cost of complications in type 2 diabetes mellitus, Arch Intern Med, 159, 1873, 10.1001/archinte.159.16.1873 Rubin, 1994, Health care expenditures for people with diabetes mellitus, 1992, J Clin Endocrinol Metab, 78, 809A, 10.1210/jcem.78.4.8157701 Jonsson, 2002, Revealing the cost of Type II diabetes in Europe, Diabetologia, 45, S5, 10.1007/s00125-002-0858-x Hotamisligil, 2006, Inflammation and metabolic disorders, Nature, 444, 860, 10.1038/nature05485 Rocchini, 2002, Childhood obesity and a diabetes epidemic, N Engl J Med, 346, 854, 10.1056/NEJM200203143461112 Grundy, 2006, Metabolic syndrome: connecting and reconciling cardiovascular and diabetes worlds, J Am Coll Cardiol, 47, 1093, 10.1016/j.jacc.2005.11.046 Alberti, 2005, The metabolic syndrome—a new worldwide definition, Lancet, 366, 1059, 10.1016/S0140-6736(05)67402-8 Grundy, 2006, Drug therapy of the metabolic syndrome: minimizing the emerging crisis in polypharmacy, Nat Rev Drug Discov, 5, 295, 10.1038/nrd2005 Despres, 1990, Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease, Arteriosclerosis, 10, 497, 10.1161/01.ATV.10.4.497 Despres, 2006, Is visceral obesity the cause of the metabolic syndrome?, Ann Med, 38, 52, 10.1080/07853890500383895 Bansilal, 2007, Role of insulin resistance and hyperglycemia in the development of atherosclerosis, Am J Cardiol, 99, 6B, 10.1016/j.amjcard.2006.11.002 Weisberg, 2003, Obesity is associated with macrophage accumulation in adipose tissue, J Clin Invest, 112, 1796, 10.1172/JCI200319246 Yudkin, 1999, C-reactive protein in healthy subjects: associations with obesity, insulin resistance,and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?, Arterioscler Thromb Vasc Biol, 19, 972, 10.1161/01.ATV.19.4.972 Lemieux, 2001, Elevated C-reactive protein: another component of the atherothrombotic profile of abdominal obesity, Arterioscler Thromb Vasc Biol, 21, 961, 10.1161/01.ATV.21.6.961 Maeda, 1996, cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1), Biochem Biophys Res Commun, 221, 286, 10.1006/bbrc.1996.0587 Scherer, 1995, A novel serum protein similar to C1q, produced exclusively in adipocytes, J Biol Chem, 270, 26746, 10.1074/jbc.270.45.26746 Cote, 2005, Adiponectinemia in visceral obesity: impact on glucose tolerance and plasma lipoprotein and lipid levels in men, J Clin Endocrinol Metab, 90, 1434, 10.1210/jc.2004-1711 Berg, 2005, Adipose tissue, inflammation, and cardiovascular disease, Circ Res, 96, 939, 10.1161/01.RES.0000163635.62927.34 Matsuzawa, 2006, Therapy Insight: adipocytokines in metabolic syndrome and related cardiovascular disease, Nat Clin Pract Cardiovasc Med, 3, 35, 10.1038/ncpcardio0380 Lemieux, 2004, Energy partitioning in gluteal-femoral fat: does the metabolic fate of triglycerides affect coronary heart disease risk?, Arterioscler Thromb Vasc Biol, 24, 795, 10.1161/01.ATV.0000126485.80373.33 Miranda, 2005, Metabolic syndrome: definition, pathophysiology, and mechanisms, Am Heart J, 149, 33, 10.1016/j.ahj.2004.07.013 Miyazaki, 2002, Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients, J Clin Endocrinol Metab, 87, 2784, 10.1210/jcem.87.6.8567 Despres, 2001, Treatment of obesity: need to focus on high risk abdominally obese patients, BMJ, 322, 716, 10.1136/bmj.322.7288.716 Ross, 2000, Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men. A randomized, controlled trial, Ann Intern Med, 133, 92, 10.7326/0003-4819-133-2-200007180-00008 Leon, 2001, Response of blood lipids to exercise training alone or combined with dietary intervention, Med Sci Sports Exerc, 33, S502, 10.1097/00005768-200106001-00021 Dumont, 2001, Effect of a six month gemfibrozil treatment and dietary recommendations on the metabolic risk profile of visceral obese men, Int J Obes Relat Metab Disord, 25, 1136, 10.1038/sj.ijo.0801665 Orchard, 2005, The effect of metformin and intensive lifestyle intervention on the metabolic syndrome: the Diabetes Prevention Program randomized trial, Ann Intern Med, 142, 611, 10.7326/0003-4819-142-8-200504190-00009 Wellen, 2005, Inflammation, stress, and diabetes, J Clin Invest, 115, 1111, 10.1172/JCI200525102 Song, 2006, Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes, Biochem Biophys Res Commun, 346, 739, 10.1016/j.bbrc.2006.05.170 Shi, 2006, TLR4 links innate immunity and fatty acid-induced insulin resistance, J Clin Invest, 116, 3015, 10.1172/JCI28898 Lin, 2000, The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes, J Biol Chem, 275, 24255, 10.1074/jbc.M002137200 Beutler, 2004, Innate immunity: an overview, Mol Immunol, 40, 845, 10.1016/j.molimm.2003.10.005 Sondergaard, 1993, Homology between the mammalian liver and the Drosophila fat body, Trends Genet, 9, 193, 10.1016/0168-9525(93)90113-V Yu, 2002, Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle, J Biol Chem, 277, 50230, 10.1074/jbc.M200958200 Chawla, 2001, Nuclear receptors and lipid physiology: opening the X-files, Science, 294, 1866, 10.1126/science.294.5548.1866 Glass, 2006, Combinatorial roles of nuclear receptors in inflammation and immunity, Nat Rev Immunol, 6, 44, 10.1038/nri1748 Castrillo, 2003, Crosstalk between LXR and toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism, Mol Cell, 12, 805, 10.1016/S1097-2765(03)00384-8 Cinti, 2005, Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans, J Lipid Res, 46, 2347, 10.1194/jlr.M500294-JLR200 Ibanez, 2007, Early Metoprolol Administration Before Coronary Reperfusion Results in Increased Myocardial Salvage. Analysis of Ischemic Myocardium at Risk Using Cardiac Magnetic Resonance, Circulation, 115, 2909, 10.1161/CIRCULATIONAHA.106.679639 Ibanez, 2007, Novel Imaging Techniques for Quantifying Overall Atherosclerotic Burden, Rev Esp Cardiol, 60, 299 Ibanez, 2007, Plaque progression and regression in atherothrombosis, J Thromb Haemost, 5, 292, 10.1111/j.1538-7836.2007.02483.x Corti, 2001, Effects of lipid-lowering by simvastatin on human atherosclerotic lesions: a longitudinal study by high-resolution, noninvasive magnetic resonance imaging, Circulation, 104, 249, 10.1161/01.CIR.104.3.249 Corti, 2002, Lipid lowering by simvastatin induces regression of human atherosclerotic lesions: two years’ follow-up by high-resolution noninvasive magnetic resonance imaging, Circulation, 106, 2884, 10.1161/01.CIR.0000041255.88750.F0 Badimon, 1990, Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit, J Clin Invest, 85, 1234, 10.1172/JCI114558 Corti, 2007, Fenofibrate induces plaque regression in hypercholesterolemic atherosclerotic rabbits: In vivo demonstration by high-resolution MRI, Atherosclerosis, 190, 106, 10.1016/j.atherosclerosis.2006.02.036 Ibanez, 2008, Rapid Change in Plaque Size, Composition and Molecular Footprint Following Recombinant ApoA-IMilano (ETC-216) Administration. Magnetic Resonance Imaging Study in an Experimental Model of Atherosclerosis, J Am Coll Cardiol, 51, 1104, 10.1016/j.jacc.2007.09.071 Rudd, 2002, Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography, Circulation, 105, 2708, 10.1161/01.CIR.0000020548.60110.76 Davies, 2005, Identification of culprit lesions after transient ischemicattack by combined 18F fluorodeoxyglucose positron-emission tomography and high-resolution magnetic resonance imaging, Stroke, 36, 2642, 10.1161/01.STR.0000190896.67743.b1 Sirol, 2004, Lipid-rich atherosclerotic plaques detected by gadofluorine-enhanced in vivo magnetic resonance imaging, Circulation, 109, 2890, 10.1161/01.CIR.0000129310.17277.E7 Amirbekian, 2007, Detecting and assessing macrophages in vivo to evaluate atherosclerosis noninvasively using molecular MRI, Proc Natl Acad Sci U S A, 104, 961, 10.1073/pnas.0606281104 Moreno, 2006, Neovascularization in human atherosclerosis, Curr Mol Med, 6, 457, 10.2174/156652406778018635 Levy, 2007, Haptoglobin genotype is a determinant of iron, lipid peroxidation, and macrophage accumulation in the atheroscleroticplaque, Arterioscler Thromb Vasc Biol, 27, 134, 10.1161/01.ATV.0000251020.24399.a2 Purushothaman, 2006, Atherosclerosis neovascularization and imaging, Curr Mol Med, 6, 549, 10.2174/156652406778018671 Hutter, 2004, Caspase-3 and tissue factor expression in lipid-rich plaque macrophages: evidence for apoptosis as link between inflammation and atherothrombosis, Circulation, 109, 2001, 10.1161/01.CIR.0000125526.91945.AE