Diabetes-Enhanced Tumor Necrosis Factor-α Production Promotes Apoptosis and the Loss of Retinal Microvascular Cells in Type 1 and Type 2 Models of Diabetic Retinopathy

The American Journal of Pathology - Tập 172 - Trang 1411-1418 - 2008
Yugal Behl1, Padmaja Krothapalli1, Tesfahun Desta1, Amanda DiPiazza1, Sayon Roy2, Dana T. Graves1
1Department of Periodontology and Oral Biology, School of Medicine, Boston University, Boston, Massachusetts
2School of Dental Medicine, and Departments of Medicine and Ophthalmology, School of Medicine, Boston University, Boston, Massachusetts

Tài liệu tham khảo

Engelgau, 2004, The evolving diabetes burden in the United States, Ann Intern Med, 140, 945, 10.7326/0003-4819-140-11-200406010-00035 Fong, 2003, Diabetic retinopathy, Diabetes Care, 26, 226, 10.2337/diacare.26.1.226 Graves, 2006, Diabetes-enhanced inflammation and apoptosis–impact on periodontal pathology, J Dent Res, 85, 15, 10.1177/154405910608500103 Cunha-Vaz, 2005, Nonproliferative retinopathy in diabetes type 2. Initial stages and characterization of phenotypes, Prog Retin Eye Res, 24, 355, 10.1016/j.preteyeres.2004.07.004 Roy, 2003, Downregulation of fibronectin overexpression reduces basement membrane thickening and vascular lesions in retinas of galactose-fed rats, Diabetes, 52, 1229, 10.2337/diabetes.52.5.1229 Yatoh, 2006, Antioxidants and an inhibitor of advanced glycation ameliorate death of retinal microvascular cells in diabetic retinopathy, Diabetes Metab Res Rev, 22, 38, 10.1002/dmrr.562 Hammes, 2005, Pericytes and the pathogenesis of diabetic retinopathy, Horm Metab Res, 37, 39, 10.1055/s-2005-861361 Sun, 2005, Aspirin at low-intermediate concentrations protects retinal vessels in experimental diabetic retinopathy through non-platelet-mediated effects, Diabetes, 54, 3418, 10.2337/diabetes.54.12.3418 Kern, 2000, Response of capillary cell death to aminoguanidine predicts the development of retinopathy: comparison of diabetes and galactosemia, Invest Ophthalmol Vis Sci, 41, 3972 Ljubimov, 2004, Involvement of protein kinase CK2 in angiogenesis and retinal neovascularization, Invest Ophthalmol Vis Sci, 45, 4583, 10.1167/iovs.04-0686 Joussen, 2002, Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression, FASEB J, 16, 438, 10.1096/fj.01-0707fje Limb, 1996, Distribution of TNF alpha and its reactive vascular adhesion molecules in fibrovascular membranes of proliferative diabetic retinopathy, Br J Ophthalmol, 80, 168, 10.1136/bjo.80.2.168 Demircan, 2006, Determination of vitreous interleukin-1 (IL-1) and tumour necrosis factor (TNF) levels in proliferative diabetic retinopathy, Eye, 20, 1366, 10.1038/sj.eye.6702138 Zhang, 2006, Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor, FASEB J, 20, 323, 10.1096/fj.05-4313fje Falappone, 2004, [The treatment of recurrent uveitis with TNF-alpha inhibitors], Reumatismo, 56, 185 Koizumi, 2003, Contribution of TNF-alpha to leukocyte adhesion, vascular leakage, and apoptotic cell death in endotoxin-induced uveitis in vivo, Invest Ophthalmol Vis Sci, 44, 2184, 10.1167/iovs.02-0589 Fauser, 2004, Pharmacokinetics and safety of intravitreally delivered etanercept, Graefes Arch Clin Exp Ophthalmol, 242, 582, 10.1007/s00417-004-0895-x Oshitari, 2006, Effect of combined antisense oligonucleotides against high-glucose-and diabetes-induced overexpression of etracellular mtrix cmponents and icreased vscular prmeability, Diabetes, 55, 86, 10.2337/diabetes.55.01.06.db05-0186 Furst, 2005, A phase 2 dose-finding study of PEGylated recombinant methionyl human soluble tumor necrosis factor type I in patients with rheumatoid arthritis, J Rheumatol, 32, 2303 Al-Mashat, 2006, Diabetes enhances mRNA levels of proapoptotic genes and caspase activity which contribute to impaired healing, Diabetes, 55, 487, 10.2337/diabetes.55.02.06.db05-1201 Kern, 1994, Comparison of retinal lesions in alloxan-diabetic rats and galactose-fed rats, Curr Eye Res, 13, 863, 10.3109/02713689409015087 Kowluru, 2002, Retinal metabolic abnormalities in diabetic mouse: comparison with diabetic rat, Curr Eye Res, 24, 123, 10.1076/ceyr.24.2.123.8158 Otani, 2004, Rescue of retinal degeneration by intravitreally injected adult bone marrow-derived lineage-negative hematopoietic stem cells, J Clin Invest, 114, 765, 10.1172/JCI200421686 Klein, 1984, Visual impairment in diabetes, Ophthalmology, 91, 1, 10.1016/S0161-6420(84)34337-8 Petrache, 2001, Differential effect of MLC kinase in TNF-alpha-induced endothelial cell apoptosis and barrier dysfunction, Am J Physiol Lung Cell Mol Physiol, 280, L1168, 10.1152/ajplung.2001.280.6.L1168 Alikhani, 2003, Lipopolysaccharides indirectly stimulate apoptosis and global induction of apoptotic genes in fibroblasts, J Biol Chem, 278, 52901, 10.1074/jbc.M307638200 Miyahara, 2003, Gene microarray analysis of experimental glaucomatous retina from cynomologous monkey, Invest Ophthalmol Vis Sci, 44, 4347, 10.1167/iovs.02-1032 Olivero, 2005, Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells, Mutagenesis, 20, 139, 10.1093/mutage/gei019 Alikhani, 2005, FOXO1 functions as a master switch that regulates gene expression necessary for tumor necrosis factor-induced fibroblast apoptosis, J Biol Chem, 280, 12096, 10.1074/jbc.M412171200 Basuroy, 2006, HO-2 provides endogenous protection against oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells, Am J Physiol Cell Physiol, 291, C897, 10.1152/ajpcell.00032.2006 Kaji, 2007, Inhibition of diabetic leukostasis and blood-retinal barrier breakdown with a soluble form of a receptor for advanced glycation end products, Invest Ophthalmol Vis Sci, 48, 858, 10.1167/iovs.06-0495 Miranda, 2006, [Oxidative stress in a model of experimental diabetic retinopathy: the utility of peroxinytrite scavengers.], Arch Soc Esp Oftalmol, 81, 27 Kowluru, 2005, Effect of advanced glycation end products on accelerated apoptosis of retinal capillary cells under in vitro conditions, Life Sci, 76, 1051, 10.1016/j.lfs.2004.10.017 Song, 1997, Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2, Proc Natl Acad Sci USA, 94, 9792, 10.1073/pnas.94.18.9792