Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial

Villar, 2017, GOLDEN anniversary of the acute respiratory distress syndrome: still much work to do!, Curr Opin Crit Care, 23, 4, 10.1097/MCC.0000000000000378 Brower, 2000, Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome, N Engl J Med, 342, 1301, 10.1056/NEJM200005043421801 Boyle, 2013, Pharmacological treatments in ARDS; a state-of-the-art update, BMC Med, 11, 166, 10.1186/1741-7015-11-166 Rhen, 2005, Anti-inflammatory action of glucocorticoids–new mechanisms for old drugs, N Engl J Med, 353, 1711, 10.1056/NEJMra050541 Meduri, 1998, Effect of prolonged methylprednisolone therapy in unresolving acute respiratory distress syndrome: a randomized controlled trial, JAMA, 280, 159, 10.1001/jama.280.2.159 Steinberg, 2006, Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome, N Engl J Med, 354, 1671, 10.1056/NEJMoa051693 Annane, 2006, Effect of low doses of corticosteroids in septic shock patients with or without early acute respiratory distress syndrome, Crit Care Med, 34, 22, 10.1097/01.CCM.0000194723.78632.62 Meduri, 2007, Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial, Chest, 131, 954, 10.1378/chest.06-2100 Annane, 2017, Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part I): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017, Crit Care Med, 45, 2078, 10.1097/CCM.0000000000002737 Meijvis, 2011, Dexamethasone and length of hospital stay in patients with community-acquired pneumonia: a randomised, double-blind, placebo-controlled trial, Lancet, 377, 2023, 10.1016/S0140-6736(11)60607-7 Bernard, 1994, The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination, Am J Respir Crit Care Med, 149, 818, 10.1164/ajrccm.149.3.7509706 Ranieri, 2012, Acute respiratory distress syndrome: the Berlin Definition, JAMA, 307, 2526 Yehya, 2019, Re-appraisal of ventilator-free days in critical care research, Am J Respir Crit Care Med, 200, 828, 10.1164/rccm.201810-2050CP Guérin, 2013, Prone positioning in severe acute respiratory distress syndrome, N Engl J Med, 368, 2159, 10.1056/NEJMoa1214103 2019, Early neuromuscular blockade in the acute respiratory distress syndrome, N Engl J Med, 380, 1997, 10.1056/NEJMoa1901686 Villar, 2016, Evaluating the efficacy of dexamethasone in the treatment of patients with persistent acute respiratory distress syndrome: study protocol for a randomized controlled trial, Trials, 17, 342, 10.1186/s13063-016-1456-4 Villar, 2007, An early PEEP/FIO2 trial identifies different degrees of lung injury in patients with acute respiratory distress syndrome, Am J Respir Crit Care Med, 176, 795, 10.1164/rccm.200610-1534OC 2013, World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects, JAMA, 310, 2191, 10.1001/jama.2013.281053 Azoulay, 2012, Dexamethasone in patients with acute lung injury from acute monocytic leukaemia, Eur Respir J, 39, 648, 10.1183/09031936.00057711 Papazian, 2007, A contributive result of open-lung biopsy improves survival in acute respiratory distress syndrome patients, Crit Care Med, 35, 755, 10.1097/01.CCM.0000257325.88144.30 Vincent, 1996, The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the working group on sepsis-related problems of the european society of intensive care medicine, Intensive Care Med, 22, 707, 10.1007/BF01709751 Schoenfeld, 2002, Statistical evaluation of ventilator-free days as an efficacy measure in clinical trials of treatments for acute respiratory distress syndrome, Crit Care Med, 30, 1772, 10.1097/00003246-200208000-00016 Villar, 2011, The ALIEN study: incidence and outcome of acute respiratory distress syndrome in the era of lung protective ventilation, Intensive Care Med, 37, 1932, 10.1007/s00134-011-2380-4 Brun-Buisson, 2004, Epidemiology and outcome of acute lung injury in European intensive care units. Results from the ALIVE study, Intensive Care Med, 30, 51, 10.1007/s00134-003-2022-6 Talmor, 2008, Mechanical ventilation guided by esophageal pressure in acute lung injury, N Engl J Med, 359, 2095, 10.1056/NEJMoa0708638 Kacmarek, 2019, Noninvasive respiratory support for post-extubation respiratory failure, Respir Care, 64, 658, 10.4187/respcare.06671 Annane, 2017, Critical illness-related corticosteroid insufficiency (CIRCI): a narrative review from a multispecialty task force of the society of critical care medicine (SCCM) and the European Society of Intensive Care Medicine (ESICM), Crit Care Med, 45, 2089, 10.1097/CCM.0000000000002724 Meduri, 2009, Activation and regulation of systemic inflammation in ARDS: rationale for prolonged glucocorticoid therapy, Chest, 136, 1631, 10.1378/chest.08-2408 Gerard, 2018, Open lung biopsy in nonresolving acute respiratory distress syndrome commonly identifies corticosteroid-sensitive pathologies, associated with better outcomes, Crit Care Med, 46, 907, 10.1097/CCM.0000000000003081 Ashbaugh, 1967, Acute respiratory distress in adults, Lancet, 2, 319, 10.1016/S0140-6736(67)90168-7 Ashbaugh, 1985, Idiopathic pulmonary fibrosis in adult respiratory distress syndrome. Diagnosis and treatment, Arch Surg, 120, 530, 10.1001/archsurg.1985.01390290012002 Pastores, 2018, Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part II): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017, Intensive Care Med, 44, 474, 10.1007/s00134-017-4951-5 Brouwer, 2013, Corticosteroids for acute bacterial meningitis, Cochrane Database Syst Rev, 6, 10.1002/14651858.CD004405.pub4 Meduri, 2018, Prolonged low-dose methylprednisolone treatment is highly effective in reducing duration of mechanical ventilation and mortality in patients with ARDS, J Intensive Care, 6, 53, 10.1186/s40560-018-0321-9 Maerz, 2011, Perioperative glycemic management in 2011: paradigm shifts, Curr Opin Crit Care, 17, 370 Melby, 1977, Clinical pharmacology of systemic corticosteroids, Annu Rev Pharmacol Toxicol, 17, 511, 10.1146/annurev.pa.17.040177.002455 Burnham, 2014, The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance, Eur Respir J, 43, 276, 10.1183/09031936.00196412 Bernard, 2001, Efficacy and safety of recombinant human activated protein C for severe sepsis, N Engl J Med, 344, 699, 10.1056/NEJM200103083441001 McKeever, 2018, Quadrupling inhaled glucocorticoid dose to abort asthma exacerbations, N Engl J Med, 378, 902, 10.1056/NEJMoa1714257 Zeuzem, 2014, Sofosbuvir and ribavirin in HCV genotypes 2 and 3, N Engl J Med, 370, 1993, 10.1056/NEJMoa1316145 Ryan, 2013, Abiraterone in metastatic prostate cancer without previous chemotherapy, N Engl J Med, 368, 138, 10.1056/NEJMoa1209096 McCarthy, 2012, Lenalidomide after stem-cell transplantation for multiple myeloma, N Engl J Med, 366, 1770, 10.1056/NEJMoa1114083 Combes, 2018, Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome, N Engl J Med, 378, 1965, 10.1056/NEJMoa1800385 Girardis, 2016, Effect of conservative vs. conventional oxygen therapy on mortality among patients in an intensive care unit. The oxygen-ICU randomized clinical trial, JAMA, 316, 1583, 10.1001/jama.2016.11993 2012, Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial, JAMA, 307, 795, 10.1001/jama.2012.137 Hébert, 1999, A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care, N Engl J Med, 340, 409, 10.1056/NEJM199902113400601 Wallis, 2018, Establishing the effectiveness of procedural interventions: the limited role of randomized trials, JAMA, 320, 2421, 10.1001/jama.2018.16329