Developmental programming: State‐of‐the‐science and future directions–Summary from a Pennington Biomedical symposium

Obesity - Tập 24 Số 5 - Trang 1018-1026 - 2016
Elizabeth F. Sutton1,2, L. Anne Gilmore1,2, David B. Dunger3, Bas Heijmans4, Marie‐France Hivert5, Charlotte Ling6, J. Alfredo Martínéz7, Susan E. Ozanne8, Rebecca A. Simmons9, Moshe Szyf10, Robert A. Waterland11, Leanne M. Redman1, Éric Ravussin1
1Clinical Sciences, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
2Elizabeth F. Sutton and L. Anne Gilmore contributed equally to this work.
3Department of Paediatrics, University of Cambridge, Cambridge, England, UK
4Leiden University Medical Center, The Hague Area, Netherlands
5Department of Population Medicine, Harvard Medical School, Boston, Massachusetts, USA
6Department of Clinical Sciences, Lund University, Malmo, Sweden
7Department of Human Nutrition, University of Navarra, CIBERobn and IDISNA, Navarra, Spain
8Department of Clinical Biochemistry, University of Cambridge, Cambridge, England, UK
9Department of Pediatrics, Perelman School of Medicine, Philadelphia, Pennsylvania, USA
10Department of Pharmacology, McGill University, Montreal, Quebec, Canada
11USDA/ARS Children's Nutrition Research Center, Department of Pediatrics-Nutrition, Baylor College of Medicine, Houston, Texas, USA

Tóm tắt

ObjectiveOn December 8–9, 2014, the Pennington Biomedical Research Center convened a scientific symposium to review the state‐of‐the‐science and future directions for the study of developmental programming of obesity and chronic disease. The objectives of the symposium were to discuss: (i) past and current scientific advances in animal models, population‐based cohort studies, and human clinical trials, (ii) the state‐of‐the‐science of epigenetic‐based research, and (iii) considerations for future studies.ResultsThis symposium provided a comprehensive assessment of the state of the scientific field and identified research gaps and opportunities for future research in order to understand the mechanisms contributing to the developmental programming of health and disease.ConclusionsIdentifying the mechanisms which cause or contribute to developmental programming of future generations will be invaluable to the scientific and medical community. The ability to intervene during critical periods of prenatal and early postnatal life to promote lifelong health is the ultimate goal. Considerations for future research including the use of animal models, the study design in human cohorts with considerations about the timing of the intrauterine exposure, and the resulting tissue‐specific epigenetic signature were extensively discussed and are presented in this meeting summary.

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Obesity

Tập 24 Số 5

1018-1026

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