Developmental consequences of abnormal folate transport during murine heart morphogenesis
Tóm tắt
Folic acid is essential for the synthesis of nucleotides and methyl transfer reactions. Folic acid–binding protein one (Folbp1) is the primary mediator of folic acid transport into murine cells.
To determine if the
Our studies revealed that impaired folic acid transport results in extensive apoptosis‐mediated cell death, which concentrated in the interventricular septum and truncus arteriosus, thus being anatomically restricted to the two regions of congenital heart defects. Together with a reduced proliferative capacity of the cardiomyocytes, the limited size of the available precursor cell pool may contribute to the observed cardiac defects. Notably, there is a substantial reduction in
Our findings demonstrate for the first time a prominent role of the
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Tài liệu tham khảo
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