Development of semicrystalline poly(vinyl alcohol) hydrogels for biomedical applications

Wiley - Tập 11 Số 3 - Trang 423-434 - 1977
Nikolaos A. Peppas1, Edward W. Merrill2
1Pediatrics
2Massachusetts Institute of Technology,

Tóm tắt

AbstractSwollen crosslinked poly(vinyl alcohol) (PVA) networks were developed and tested as potential biomaterials. They were prepared by electron‐beam irradiation of aqueous PVA solutions at various temperatures and doses of irradiation. These materials were characterized by low mechanical properties and especially by low elongation at break and ultimate tensile strength. Reinforcement was achieved by a two‐stage dehydration‐annealing process, introducing crystallites in the polymeric network. Improved mechanical properties were achieved due to the presence of this crystalline PVA phase. Due to their structure, these hydrogels are proposed to be used as biomembranes for selective transport of macromolecules and as biomaterials for synthetic articular cartilage applications. Surface heparinization was accomplished by reacting heparin to the hydroxyl groups of the PVA surface, through covalent acetal bridges.

Từ khóa


Tài liệu tham khảo

Salzman E. W., 1971, Blood, 38, 509, 10.1182/blood.V38.4.509.509

J. D.Andrade paper presented at the XXII IUPAC Congress

1971, Macromol. Prepr., 1, 620

10.1016/0032-3861(75)90249-9

10.1002/pen.760150409

Movshovich I. A., 1974, Med. Tekhn., 5, 15

10.1002/jbm.820070506

Dinnar U., 1975, CRC, Crit. Rev. Bioeng., 2, 159

10.1002/pi.4980070204

10.1002/app.1970.070140903

10.1002/app.1972.070160320

10.1002/pol.1973.180110210

10.1002/app.1975.070190518

J. C.Bray Sc.D. Thesis MIT 1972.

N. A.Peppas Sc.D. Thesis MIT 1973.

Merrill E. W., 1970, J. Appl. Physiol., 29, 723, 10.1152/jappl.1970.29.5.723

Merrill E. W., 1972, Polym. Prepr., 13, 511

E. W.MerrillandP. S. L.Wong U.S. Pat. 3 658 745 (Apr. 25 1972).

Merrill E. W., 1972, Chim. Ind. Gen. Chim., 41, 105

10.1002/pol.1976.170140215

10.1002/app.1973.070171219

10.1002/app.1976.070200604

Finch C. A., 1973, PV A—Properties and Applications

10.1002/pol.1959.1203512916

10.1002/pol.1976.170140216

10.1295/koron1944.11.472

Flory P. J., 1953, Principles of Polymer Chemistry

10.1002/jbm.820010107

Thông tin
Thông tin xuất bản

Wiley

Tập 11 Số 3

423-434

Thông tin tác giả