Development of rapid light-chain deposition disease in hepatic arteries with severe ischemic cholangitis in a multiple myeloma patient treated with melphalan, prednisone and lenalidomide

Katja Weisel1, Michael Böckeler2, Leonardo Bianchi3, Luigi Terracciano3, Frank Mayer2, Lothar Kanz2
1University of Tübingen
2Medical Center, Department of Hematology, Oncology and Immunology, University of Tübingen, Tübingen, Germany
3Institute for Pathology, Freiburg, Germany

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Buxbaum JN, Chuba JV, Hellmann GC, Solomon A, Gallo GR. Monoclonal immunoglobulin deposition disease: light chain and light and heavy chain deposition disease and their relation to light chain amyloidosis. Ann Intern Med. 1990;112:455–64.

Randall RE, Williamson WC, Mullinax F, Tung MY, Still WJS. manifestations of systemic light deposition. Am J Med. 1976;60:293–9. doi: 10.1016/0002-9343(76)90440-X .

Confalonieri R, Barbiano di Belgioioso G, Banfi G, Ferrario F, Bertani T, Pozzi C, et al. Light chain nephropathy: histological and clinical aspects in 15 cases. Nephrol Dial Transplant. 1988;3:150–6.

Kijner CH, Yousem SY. Systemic light chain deposition disease presenting as pulmonary nodules. Am J Surg Pathol. 1988;12:405–13. doi: 10.1097/00000478-198805000-00009 .

Stone GC, Wall BA, Oppliger IR, Werner MH, Jolly SL, Aguirre A, et al. A vasculopathy with deposition of lamda light chain crystals. Ann Intern Med. 1989;110:275–8.

Gireli C, Giovanni L, Rocca F. Light chain deposition disease of the liver. Eur J Gastroenterol Hepatol. 1999;10:429–30.

Pozzi C, D’Amico M, Fogazzi GB, Curioni S, Ferrario F, Pasquali S, et al. Light chain deposition disease with renal involvement: clinical characteristics and prognostic factors. Am J Kidney Dis. 2003;42:1154–63. doi: 10.1053/j.ajkd.2003.08.040 .

Royer B, Arnulf B, Martinez F, Roy L, Flageul B, Etienne I, et al. High dose chemotherapy in light chain or light and heavy chain deposition disease. Kidney Int. 2004;65:642–8. doi: 10.1111/j.1523-1755.2004.00427.x .

Samanez C, Domingo A, Cibeira MT, Miquel R, Soler M, Bladé J. Development of rapidly progressive liver light chain deposition under VAD chemotherapy in multiple myeloma. Eur J Haematol. 2006;76:83–5. doi: 10.1111/j.1600-0609.2005.00561.x .

Michopoulos S, Petraki K, Petraki C, Dimopoulos MA. Light chain deposition disease of the liver without renal involvement in a patient with multiple myeloma related to liver failure and rapid fatal outcome. Dig Dis Sci. 2002;47:730–4. doi: 10.1023/A:1014773512707 .

Deltenre P, Valla DC. Ischemic cholangiopathy. J Hepatol. 2006;44:806–17. doi: 10.1016/j.jhep.2006.01.009 .

Hussein S, Browne R, Chen J, Parekh S. Lenalidomide-induced severe hepatotoxicity. Blood. 2007;110:3814. doi: 10.1182/blood-2007-06-097758 .