Development of mucoadhesive Timolol loaded chitosan-nanocomposite to treat glaucoma

Subrizi, 2019, Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties, Drug Discov. Today, 24, 1446, 10.1016/j.drudis.2019.02.001 Joseph, 2017, Drug delivery to the eye: what benefits do nanocarriers offer?, Nanomedicine (London), 12, 683, 10.2217/nnm-2016-0379 Kumara, 2021, Why chitosan could be apt candidate for glaucoma drug delivery - an overview, Int. J. Biol. Macromol., 176, 47, 10.1016/j.ijbiomac.2021.02.057 Acharya, 2019, Development and characterization of prolonged release Timolol maleate cubosomal gel for ocular drug delivery, Adv. Pharm. J., 4, 1, 10.31024/apj.2019.4.1.1 Shokry, 2018, Exploring gelatin nanoparticles as novel nanocarriers for Timolol maleate: augmented in-vivo efficacy and safe histological profile, Int. J. Pharm., 545, 229, 10.1016/j.ijpharm.2018.04.059 Cuggino, 2021, Mucoadhesive and responsive nanogels as carriers for sustainable delivery of timolol for glaucoma therapy, Mater. Sci. Eng. C, 118, 10.1016/j.msec.2020.111383 Khare, 2015, Mucoadhesive polymers for enhancing retention in ocular drug delivery, 451 de Campos, 2004, Chitosan nanoparticles as new ocular drug delivery systems: in vitro stability, in vivo fate, and cellular toxicity, Pharm. Res., 21, 803, 10.1023/B:PHAM.0000026432.75781.cb Zingale, 2022, Fluorescent nanosystems for drug tracking and theranostics: recent applications in the ocular field, Pharmaceutics, 14, 955, 10.3390/pharmaceutics14050955 Hoffman, 2020, Use of fluorescent dyes in endoscopy and diagnostic investigation, Visc. Med., 36, 95, 10.1159/000506241 Zhao, 2018, Single photon emission from graphene quantum dots at room temperature, Nat. Commun., 9, 3470, 10.1038/s41467-018-05888-w Kumara, 2023, Synthesis, properties and potential applications of photoluminescent carbon nanoparticles: a review, Anal. Chim. Acta, 1268, 341430, 10.1016/j.aca.2023.341430 Misra, 2017, Macromolecularly “caged” carbon nanoparticles for intracellular trafficking via switchable photoluminescence, J. Am. Chem. Soc., 139, 1746, 10.1021/jacs.6b11595 Srivastava, 2021, Luminescence switching in polymerically confined carbon nanoparticles triggered by UV-light, Nanoscale, 13, 16288, 10.1039/D1NR02786G Kumara, 2022, Novel chitosan - graphene quantum dots composite for therapeutic delivery and tracking through enzymatic stimuli response, Carbohydr. Polym., 289, 10.1016/j.carbpol.2022.119426 Tighsazzadeh, 2019, Development and evaluation of performance characteristics of timolol-loaded composite ocular films as potential delivery platforms for treatment of glaucoma, Int. J. Pharm., 566, 111, 10.1016/j.ijpharm.2019.05.059 Rao, 2020, Microwave-assisted rapid synthesis of silver nanoparticles using fucoidan: characterization with assessment of biocompatibility and antimicrobial activity, Int. J. Biol. Macromol., 163, 745, 10.1016/j.ijbiomac.2020.06.230 Sun, 2015, Ultra-high quantum yield of graphene quantum dots: aromatic-nitrogen doping and photoluminescence mechanism, Part. Part. Syst. Charact., 32, 434, 10.1002/ppsc.201400189 Tan, 2017, Bioadhesive chitosan-loaded liposomes: a more efficient and higher permeable ocular delivery platform for timolol maleate, Int. J. Biol. Macromol., 94, 355, 10.1016/j.ijbiomac.2016.10.035 de Sá, 2015, Liposomal voriconazole (VOR) formulation for improved ocular delivery, Colloids Surf. B: Biointerfaces, 133, 331, 10.1016/j.colsurfb.2015.06.036 Uthaiwat, 2021, Characteristic evaluation of gel formulation containing niosomes of melatonin or its derivative and mucoadhesive properties using ATR-FTIR spectroscopy, Polymers, 13, 1142, 10.3390/polym13071142 Saiano, 2002, Evaluation of mucoadhesive properties of α,β-poly(N-hydroxyethyl)-dl-aspartamide and α,β-poly(aspartylhydrazide) using ATR–FTIR spectroscopy, Polymer, 43, 6281, 10.1016/S0032-3861(02)00504-9 Aeinehvand, 2017, Synthesis of poly(2-hydroxyethyl methacrylate)-based molecularly imprinted polymer nanoparticles containing Timolol maleate: morphological, thermal, and drug release along with cell biocompatibility studies, Polym. Adv. Technol., 28, 828, 10.1002/pat.3986 Morsi, 2016, Improved bioavailability of timolol maleate via transdermal transfersomal gel: statistical optimization, characterization, and pharmacokinetic assessment, J. Adv. Res., 7, 691, 10.1016/j.jare.2016.07.003 G.v, 2021, Preparation and characterization of dexamethasone loaded sodium alginate-graphene oxide microspheres for bone tissue engineering, J. Drug Deliv. Sci. Technol., 64 Xu, 2019, Co-delivery of latanoprost and timolol from micelles-laden contact lenses for the treatment of glaucoma, J. Control. Release, 305, 18, 10.1016/j.jconrel.2019.05.025 Kodoth, 2019, Pectin-based silver nanocomposite film for transdermal delivery of Donepezil, Int. J. Biol. Macromol., 134, 269, 10.1016/j.ijbiomac.2019.04.191 Ghate, 2019, Colloidal nanostructured lipid carriers of pentoxifylline produced by microwave irradiation ameliorates imiquimod-induced psoriasis in mice, Colloids Surf. B: Biointerfaces, 181, 389, 10.1016/j.colsurfb.2019.05.074 Mosmann, 1983, Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays, J. Immunol. Methods, 65, 55, 10.1016/0022-1759(83)90303-4 Vethakanraj, 2015, Targeting ceramide metabolic pathway induces apoptosis in human breast cancer cell lines, Biochem. Biophys. Res. Commun., 464, 833, 10.1016/j.bbrc.2015.07.047 Dhanavel, 2020, Chitosan/reduced graphene oxide/Pd nanocomposites for co-delivery of 5-fluorouracil and curcumin towards HT-29 colon cancer cells, Polym. Bull., 77, 5681, 10.1007/s00289-019-03039-9 Mathew, 2021, Dopamine-conjugated CuS/chitosan nanocomposite for targeted photothermal drug delivery: in vitro cytotoxicity study to establish bio-compatibility, J. Drug Deliv. Sci. Technol., 61, 102193, 10.1016/j.jddst.2020.102193 Silva, 2017, Chitosan nanoparticles as a mucoadhesive drug delivery system for ocular administration, Mar. Drugs, 15, 370, 10.3390/md15120370 Zamboulis, 2020, Chitosan and its derivatives for ocular delivery formulations: recent advances and developments, Polymers, 12, 1519, 10.3390/polym12071519 El-Feky, 2020, Reduction of intraocular pressure using timolol orally dissolving strips in the treatment of induced primary open-angle glaucoma in rabbits, J. Pharm. Pharmacol., 72, 682, 10.1111/jphp.13239 Hanna, 1995, Determination of the optical purity of timolol maleate by proton nuclear magnetic resonance spectroscopy with a chiral Pr(III) shift reagent, J. Pharm. Biomed. Anal., 13, 1313, 10.1016/0731-7085(95)01556-Z Hu, 2017, Facile hydrothermal synthesis of SnO2 nanospheres as photocatalysts, J. Nanomater., 2017, 10.1155/2017/6976203 Kumar, 2017, Tunable (violet to green) emission by high-yield graphene quantum dots and exploiting its unique properties towards sun-light-driven photocatalysis and supercapacitor electrode materials, Mater. Today Commun., 11, 76, 10.1016/j.mtcomm.2017.02.009 A one-step hydrothermal method of nitrogen-doped graphene quantum dots decorated graphene for fabrication of paper-based fluorescent composite: BioResources, (n.d.). https://bioresources.cnr.ncsu.edu/ (accessed May 3, 2023). Kumar, 2012, Physiochemical, optical and biological activity of chitosan-chromone derivative for biomedical applications, Int. J. Mol. Sci., 13, 6102, 10.3390/ijms13056102 Aziz, 2017, Polymer blending as a novel approach for tuning the SPR peaks of silver nanoparticles, Polymers (Basel), 9, 486, 10.3390/polym9100486 Bochaton, 2015, X-ray microtomography provides first data about the feeding behaviour of an endangered lizard, the Montserrat galliwasp (Diploglossus montisserrati), R. Soc. Open Sci., 2, 150461, 10.1098/rsos.150461 Katas, 2013, Development of chitosan nanoparticles as a stable drug delivery system for protein/siRNA, Int. J. Biomater., 2013, 10.1155/2013/146320 Leal, 2017, Physicochemical properties of mucus and their impact on transmucosal drug delivery, Int. J. Pharm., 532, 555, 10.1016/j.ijpharm.2017.09.018 Boegh, 2015, Mucus as a barrier to drug delivery – understanding and mimicking the barrier properties, Basic Clin. Pharmacol. Toxicol., 116, 179, 10.1111/bcpt.12342 Lai, 2009, Micro- and macrorheology of mucus, Adv. Drug Deliv. Rev., 61, 86, 10.1016/j.addr.2008.09.012 He, 1998, In vitro evaluation of the mucoadhesive properties of chitosan microspheres, Int. J. Pharm., 166, 75, 10.1016/S0378-5173(98)00027-1 Shin, 2021, Comparative study of chitosan and oligochitosan coatings on mucoadhesion of curcumin nanosuspensions, Pharmaceutics, 13, 2154, 10.3390/pharmaceutics13122154 El-Feky, 2018, Chitosan-gelatin hydrogel crosslinked with oxidized sucrose for the ocular delivery of Timolol maleate, J. Pharm. Sci., 107, 3098, 10.1016/j.xphs.2018.08.015 Papadimitriou, 2008, Chitosan nanoparticles loaded with dorzolamide and pramipexole, Carbohydr. Polym., 73, 44, 10.1016/j.carbpol.2007.11.007 Silva, 2012, Interaction of chitosan and mucin in a biomembrane model environment, J. Colloid Interface Sci., 376, 289, 10.1016/j.jcis.2012.03.027 Velos, 1985, An improved method for measuring human tear lysozyme concentration, Arch. Ophthalmol., 103, 31, 10.1001/archopht.1985.01050010035012 Huang, 2013, Enhanced fluorescence of chitosan based on size change of micelles and application to directly selective detecting Fe3+ in humanserum, Biosens. Bioelectron., 42, 539, 10.1016/j.bios.2012.10.098