Development of biochemical heterogeneity of articular cartilage: influences of age and exercise
Tóm tắt
The objective of this study was to document the development of biochemical heterogeneity from birth to maturity in equine articular cartilage, and to test the hypothesis that the amount of exercise during early life may influence this process. Neonatal foals showed no biochemical heterogeneity whatsoever, in contrast to a clearbiochemical heterogeneity in mature horses. The process of formation of site differences was almost completed in exercised foals age 5 months, but was delayed in those deprived of exercise. For some collagen‐related parameters, this delay was not compensated for after an additional 6 month period of moderate exercise.
It is concluded that the functional adaptation of articular cartilage, as reflected in the formation of biochemical heterogeneity in the horse, occurs forthe most part during the first 5 months
Từ khóa
Tài liệu tham khảo
Brama P.A.J., 1999, Influence of site and age on biochemical characteristics of the collagen network of equine articular cartilage, Am. J. vet. Res., 60, 341, 10.2460/ajvr.1999.60.03.341
Maroudas A., 1980, Studies in Joint Diseases, 59
Mcllwraith C.W., 1996, Joint Disease in the Horse, 40
Palmer J.L., 1996, Joint Disease in the Horse, 104
Palmer J.L., 1995, Site‐specific proteoglycan characteristics of third carpal articular cartilage in exercised and nonexercised horses, Am. J. vet. Res., 56, 1570, 10.2460/ajvr.1995.56.12.1570
Rosenberg L.C., 1986, Articular Cartilage Biochemistry, 39
Scott J.E., 1994, The chemical morphology of age‐related changes in human intervertebral disc glycosaminoglycans from cervical, thoracic and lumbar nucleus pulposes and annulus fibrosus, J. Anat., 184, 73