Development of biochemical heterogeneity of articular cartilage: influences of age and exercise

Equine Veterinary Journal - Tập 34 Số 3 - Trang 265-269 - 2002
Pieter A.J. Brama1, J.M. TeKoppele2, Ruud A. Bank2, A. Barneveld1, P. René van Weeren1
1Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 12, NL-3584 CM Utrecht, The Netherlands
2Gaubius Laboratory TNO Prevention and Health, Division of Vascular and Connective Tissue Research, Leiden, The Netherlands

Tóm tắt

SummaryThe objective of this study was to document the development of biochemical heterogeneity from birth to maturity in equine articular cartilage, and to test the hypothesis that the amount of exercise during early life may influence this process. Neonatal foals showed no biochemical heterogeneity whatsoever, in contrast to a clearbiochemical heterogeneity in mature horses. The process of formation of site differences was almost completed in exercised foals age 5 months, but was delayed in those deprived of exercise. For some collagen‐related parameters, this delay was not compensated for after an additional 6 month period of moderate exercise.It is concluded that the functional adaptation of articular cartilage, as reflected in the formation of biochemical heterogeneity in the horse, occurs forthe most part during the first 5 monthspostpartum. A certain level of exercise seems essential forthis process and withholding exercise in early life, may result in a delay in the adaptation of the cartilage.

Từ khóa


Tài liệu tham khảo

10.1006/abio.1996.0346

10.1042/bj3300345

10.1016/S0378-4347(97)00391-5

Brama P.A.J., 1999, Influence of site and age on biochemical characteristics of the collagen network of equine articular cartilage, Am. J. vet. Res., 60, 341, 10.2460/ajvr.1999.60.03.341

10.2746/042516400776563626

10.2746/042516400777612062

10.2746/042516401776767377

10.1146/annurev.bi.53.070184.003441

10.1042/bj1880823

10.3109/03008208209160269

10.1016/B978-0-12-655102-0.50011-4

10.1016/S1063-4584(97)80031-3

Maroudas A., 1980, Studies in Joint Diseases, 59

10.3109/03008209209015033

Mcllwraith C.W., 1996, Joint Disease in the Horse, 40

Palmer J.L., 1996, Joint Disease in the Horse, 104

Palmer J.L., 1995, Site‐specific proteoglycan characteristics of third carpal articular cartilage in exercised and nonexercised horses, Am. J. vet. Res., 56, 1570, 10.2460/ajvr.1995.56.12.1570

Rosenberg L.C., 1986, Articular Cartilage Biochemistry, 39

Scott J.E., 1994, The chemical morphology of age‐related changes in human intervertebral disc glycosaminoglycans from cervical, thoracic and lumbar nucleus pulposes and annulus fibrosus, J. Anat., 184, 73

10.1016/0003-2697(88)90532-5

Thông tin
Thông tin xuất bản

Equine Veterinary Journal

Tập 34 Số 3

265-269

Thông tin tác giả