Development of an intravenously injectable chemically stable aqueous omeprazole formulation using nanosuspension technology

European Journal of Pharmaceutics and Biopharmaceutics - Tập 58 Số 3 - Trang 615-619 - 2004
Jan P. Möschwitzer1, Georg Achleitner2, Herbert Pomper2, Rainer Müller1
1Department of Pharmaceutical Technology, Biotechnology and Quality Management, Free University of Berlin, Berlin, Germany
2Fresenius Kabi Austria GmbH, Graz, Austria

Tóm tắt

Từ khóa


Tài liệu tham khảo

Castro, 1999, Comparison of derivative spectrophotometric and liquid chromatograpic methods for the determination of omeprazole in aqueous solutions during stability studies, J. Pharm. Biomed. Anal, 21, 291, 10.1016/S0731-7085(99)00136-3

SRC PhysProp Database, Internet available.

G. Liversidge, IIR Drug Delivery Partnerships™ Meeting, Workshop ‘Nanotechnology—solid particles, lipids and nanocomplexes’, Cologne/Germany, 11–13 June, 2003.

R.H. Müller, K. Mäder, K. Krause, Verfahren zur schonenden Herstellung von hochfeinen Micro-/Nanopartikeln, PCT Application PCT/EP00/06535, Germany, 2000.

J.E. Kipp, J.C.T. Wong, M.J. Doty, C.L. Rebbeck, Microprecipitation method for preparing submicron suspensions, United States Patent, 6,607,784 (2003).

R.H. Muller, R. Becker, B. Kruss, K. Peters, Pharmaceutical nanosuspensions for medicament administration as systems with increased saturation solubility and rate of solution, United States Patent, 5, 858, 410 (1999).

Nyström, 1998, Dissolution properties of poorly soluble drugs: theoretical background and possibilities to improve the dissolution behaviour, 143

K. Peters, Nanosuspensions—a novel formulation principle for poorly soluble drugs, PhD thesis, Free University Berlin, Berlin, 1999.

E. Liversidge, L. Wei, Stabilization of chemical compounds using nanoparticulate formulations, United States Patent No. 0054042 A1 (2003).

Müller, 2003, DissoCubes—a novel formulation for poorly soluble and poorly bioavailable drugs, vol. 126, 135