Development of an Established Name: Analyzing Stem Based United States Adopted Naming
Tóm tắt
Objectives: This retrospective analysis classifies US adopted naming (USAN) stems based on how the stem is defined. This analysis seeks to identify “commonalities” among stems, discuss medication errors due to drug name issues, identify inconsistencies of the stem-based naming system, and discuss possible solutions to the problem, including education of health care providers.Methods: Stems were tagged by up to four descriptors, invented by the author, according to their definition(s). These descriptors are prototype, therapeutic use, mechanism of action, and composition. Unordered combinations of the four descriptors produced 15 possible subsets. A search of the USAN dictionary was conducted to identify drug names that mis-incorporated a stem. On the basis of the data collected, the authors were able to identify inconsistencies with the naming system.Results: Of the 383 stems on the USAN stem list, 312 (81.46%) were classified into one of the 15 subsets. The six most frequently occupied subsets account for 287 of the 312 stems originally classified (91.99%). These six subsets, in order of decreasing frequency are prototype/use, mechanism of action (MOA), prototype, use/MOA, and prototype/MOA.Conclusion: Misincorporation of a stem into a drug name may result in confusion as to the nature and use of a drug. Proper incorporation of a stem into a drug name is easiest when the stem’s definition is simple, that is, fits only one descriptor. Since the ultimate goal of a drug name is to convey simple and useful information to a health care professional, stems should be incorporated correctly. Our data does not give enough information to support how drugs should be named (for example, only with stems that show MOA), but it clearly shows that drugs should not be named with stems that are misincorporated, or that fit many or all of the descriptors, since this leads to confusion and medication errors. Education of health care professionals and consumers is important to address existing drug names with misincorporated stems and to prevent misincorporation of stems from occurring in the future.
Tài liệu tham khảo
Phillips J, Beam S, Brinker A, et al. Retrospective analysis of mortalities associated with medication errors. Am J Health-Syst Pharm. 2001;58:1835–1841.
Thomas MR, Hoquist C, Phillips J. Med error reports to FDA show mixed bag. Drug Topics. October 2001;23–24.
Lesar TS, Briceland L, Stein DS. Factors related to errors in medication prescribing. JAMA. 1997;4:312–317.
Time and process required to obtain a USAN. Available at: http://www.ama-assn.org/ama/pub/category/4795.html. Accessed September 17, 2003.
USP Dictionary of USAN and International Drug Names. 39th ed. Rockville: US Pharmacopeia; 2003.
United States Adopted Names. Available at: http://www.ama-assn.org/ama/pub/category/2956.html. Accessed September 17, 2003.
USAN Stems. Available at: http://www.ama-assn.org/ama/pub/category/4782.html. Accessed September 17, 2003.
Prozac Product/Prescribing Information. Available at: http://www.prozac.com/prescribing_info.jsp. Accessed December 6, 2003.
Paxil Product/Prescribing Information. Available at: http://www.paxil.com. Accessed December 06, 2003.
Zoloft Product/Prescribing Information. Available at: http://www.zoloft.com/index.asp?pageid=43. Accessed December 6, 2003.
Strattera Product/Prescribing Information. Available at: http://www.strattera.com/1_6_hcp/1_6_1_prescribing.jsp. December 6, 2003.
Brunton LL. Agents for control of gastric acidity and treatment of peptic ulcers. In: Hardman JG, Limbird LE, eds. Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 9th ed. New York: McGraw-Hill; 1996:904–907.
Abilify Product/Prescribing Information. Available at: http://www.abilify.com. Accessed December 06, 2003.
Ross EM. Pharmacodynamics: mechanisms of drug action and the relationship between drug concentration and effect. In: Hardman JG, Limbird LE, eds. Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 9th ed. New York: McGraw-Hill; 1996:29–41.
Nies AS, Spielberg SP. Principles of therapeutics. In: Hardman JG, Limbird LE, eds. Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 9th ed. New York: McGraw-Hill; 1996:43–61.
Viagra Product/Prescribing Information. Available at: http://www.viagraMD.com. Accessed February 27, 2004.
Levitra Product/Prescribing Information. Available at: http://www.levitra.com/hcp/index.htm. Accessed February 27, 2004.
Cialis Product/Prescribing Information. Available at: http://www.cialis.com. Accessed February 27, 2004.
Relenza Product/Prescribing Information. Available at: http://www.gsk.com/products/relenza_us.htm. Accessed February 27, 2004.
Tamiflu Product/Prescribing Information. Available at: http://www.tamiflu.com/hcp/neuramin/neura_index.asp. Accessed February 27, 2004.
Thaisrivongs S, Strohbach J. Structure-based discovery of tipranavir disodium (PNU-140690E): a potent, orally bioavailable, nonpeptidic HIV protease inhibitor. Biopolymers. 1999;51:51–58.
Meridia Product/Prescribing Information. Available at: http://www.meridia.net. Accessed February 27, 2004.