Development of a novel osmotically driven drug delivery system for weakly basic drugs

C. Guthmann1,2, R. Lipp3, T. Wagner1, H. Kranz1
1Pharmaceutical Development, Bayer Schering Pharma AG, Berlin, Germany
2College of Pharmacy, Freie Universität Berlin, Berlin, Germany
3Eli Lilly and Company, Lilly Research Laboratories, IN, USA

Tài liệu tham khảo

Timmins, 1997, Optimization and characterization of a pH-independent extended-release hydrophilic matrix tablet, Pharm. Dev. Technol., 2, 25, 10.3109/10837459709022606 Varma, 2005, Influence of micro-environmental pH on the gel layer behavior and release of a basic drug from various hydrophilic matrices, J. Control. Release, 103, 499, 10.1016/j.jconrel.2004.12.015 Vijay, 1988, Effect of the pH on the in vitro dissolution and in vivo absorption of controlled release theophylline in dogs, J. Pharm. Sci., 77, 760, 10.1002/jps.2600770908 Streubel, 2000, pH-independent release of a weakly basic drug from water-insoluble and -soluble matrix tablets, J. Control. Release, 67, 101, 10.1016/S0168-3659(00)00200-5 Gohel, 2003, Studies in preparation and evaluation of pH-independent sustained-release matrix tablets of verapamil HCl using directly compressible Eudragits, Pharm. Dev. Technol., 8, 323, 10.1081/PDT-120024686 Kranz, 2005, Development of a single unit extended release formulation for ZK 811 752, a weakly basic drug, Eur. J. Pharm. Sci., 26, 47, 10.1016/j.ejps.2005.04.018 Kranz, 2005, Development of a multi particulate extended release formulation for ZK 811 752, a weakly basic drug, Int. J. Pharm., 299, 84, 10.1016/j.ijpharm.2005.04.026 Siepe, 2006, Strategies for the design of hydrophilic matrix tablets with controlled microenvironmental pH, Int. J. Pharm., 316, 14, 10.1016/j.ijpharm.2006.02.021 Siepe, 2006, Microenvironmental pH and microviscosity inside pH-controlled matrix tablets: an EPR imaging study, J. Control. Release, 112, 72, 10.1016/j.jconrel.2005.12.021 Takka, 2001, Effect of anionic polymers on the drug release of propranolol hydrochloride from matrix tablets, Eur. J. Pharm. Biopharm., 52, 75, 10.1016/S0939-6411(01)00147-3 Lecomte, 2003, Blends of enteric and GIT-insoluble polymers used for film coating: physicochemical characterization and drug release patterns, J. Control. Release, 89, 457, 10.1016/S0168-3659(03)00155-X Amighi, 1998, Peroral sustained-release film-coated pellets as a means to overcome physicochemical and biological drug-related problems. I. In vitro development and evaluation, Drug Dev. Ind. Pharm., 24, 509, 10.3109/03639049809085651 Dashevsky, 2004, pH-independent release of a basic drug from pellets coated with the extended release polymer dispersion Kollicoat® SR 30 D and the enteric polymer dispersion Kollicoat® MAE 30 DP, Eur. J. Pharm. Biopharm., 58, 45, 10.1016/j.ejpb.2004.03.013 McGinity, 1997