Development of a drug delivery system for the treatment of periodontal disease based on bioerodible poly(ortho esters)

Socransky, 1977, Microbiology of periodontal disease—Present status and future considerations, J Periodontol, 48, 497, 10.1902/jop.1977.48.9.497 Listgarten, 1978, Relative distribution of bacteria at clinically healthy and periodontally diseased sites in humans, J Clin Periodontol, 5, 115, 10.1111/j.1600-051X.1978.tb01913.x Slots, 1979, Subgingival microflora and periodontal disease, J Clin Periodontol, 6, 351, 10.1111/j.1600-051X.1979.tb01935.x Dzink, 1985, Gram-negative species associated with active destructive periodontol lesions, J Clin Periodontol, 12, 648, 10.1111/j.1600-051X.1985.tb00936.x Dzink, 1988, The predominant cultivable microbiota of active and inactive lesions of destructive periodontal diseases, J Clin Periodontol, 15, 316, 10.1111/j.1600-051X.1988.tb01590.x Haffajee, 1988, Clinical, microbiological and immunological features of subjects with destructive periodontal diseases, J Clin Periodontol, 15, 240, 10.1111/j.1600-051X.1988.tb01577.x Loesche, 1988, The role of Spirochaetes in periodontal disease, Adv Dent Res, 2, 275, 10.1177/08959374880020021201 Slots, 1988, Bacteroides gingivalis, Bacteroides intermedius and Actinobacillus actinomycetem-comitans in human periodontal disease, J Clin Periodontol, 15, 85, 10.1111/j.1600-051X.1988.tb00999.x Lindhe, 1984, Liljenberg. Treatment of localized juvenile periodontitis, J Clin Periodontol, 11, 399, 10.1111/j.1600-051X.1984.tb01338.x McCulloch, 1989, Efficacy of doxycycline in prevention of recurrent periodontitis, J Dent Res, 68, 916 Loesche, 1987, Metronidazole therapy for periodontitis, J Periodont Res, 22, 224, 10.1111/j.1600-0765.1987.tb01574.x Lynch, 1989, A combination of platelet-derived and insulin-like growth factors enhances periodontal regeneration, J Clin Periodontol, 16, 545, 10.1111/j.1600-051X.1989.tb02334.x Urquhart, 1982, Rate-controlled drug dosage, Drugs, 23, 207, 10.2165/00003495-198223030-00003 Goodson, 1985, Periodontal disease treatment by local drug delivery, J Periodontol, 56, 265, 10.1902/jop.1985.56.5.265 Dunn, 1982, Monolithic fibers for controlled delivery of tetracycline, 157 Goodson, 1983, Monolithic tetracycline-containing fibers for controlled delivery to periodontal pocket, J Periodontol, 54, 575, 10.1902/jop.1983.54.10.575 Tonetti, 1990, Zero-order delivery with periodontal placement of tetracycline-loaded ethylene vinyl acetate fibers, J Periodont Res, 25, 243, 10.1111/j.1600-0765.1990.tb00911.x Goodson, 1991, Multicenter evaluation of tetracycline fiber therapy: II. Clinical response, J Periodont Res, 26, 371, 10.1111/j.1600-0765.1991.tb02076.x Goodson, 1989, Comparative response of mobile teeth following monolithic fiber therapy or scaling, Compend Cont Educ Dent, Suppl, S418 Addy, 1988, Use of antimicrobial-containing acrylic strips in the treatment of chronic periodontal disease, J Periodontol, 59, 557, 10.1902/jop.1988.59.9.557 Soskoline, 1983, New sustained release dosage form of chlorhexidine for dental use, J Periodontol Res, 18, 330, 10.1111/j.1600-0765.1983.tb00368.x Baker, 1988, A controlled release drug delivery system for the periodontal pocket, 15, 238a Friedman M, Steinberg D, Soskolne A, Sela M. European Patent Application No. 0246809. Nov. 25: 1987. Steinberg, 1990, A new degradable controlled release device for treatment of periodontal disease: in vitro release study, J Periodontol, 61, 393, 10.1902/jop.1990.61.7.393 Larsen, 1990, In vivo release of doxycycline from bioabsorbable materials and acrylic strips, J Periodontol, 61, 30, 10.1902/jop.1990.61.1.30 Minabe, 1989, Application of a local drug delivery system to periodontal therapy, J Periodontol, 60, 113, 10.1902/jop.1989.60.2.113 Noguchi, 1988, Periodontal treatment by local drug delivery using resorbable base material, Adv Dent Res, 2, 401, 10.1177/08959374880020023701 Heller, 1990, Controlled drug release from bioerodible hydrophobic ointments, Biomaterials, 11, 235, 10.1016/0142-9612(90)90003-9 Fusayama, 1963, Corrosion of gold and amalgam placed in contact with each other, J Dent Res, 42, 1183, 10.1177/00220345630420051301 Heller, 1992, Synthesis and characterization of a new family of poly(ortho esters), Macromolecules, 24, 3362, 10.1021/ma00039a007 Wuthrich, 1992, Pulsatile and delayed release of lysozyme from ointment-like poly(ortho esters), J Control Rel, 21, 191, 10.1016/0168-3659(92)90021-I Smyth, 1969, Experimental toxicity and metabolism of 1,2,6-hexanetriol, Tox Appl Pharmacol., 15, 282, 10.1016/0041-008X(69)90028-3 Bernanchez, 1993, Biotolerance of a semisolid hydrophobic biodegradable poly(ortho ester) for controlled drug delivery, J Biomed Mater Res, 27, 677, 10.1002/jbm.820270515 Heller, 1993, Poly(ortho esters), Adv Polym Sci, 107, 41, 10.1007/BFb0027551 Rao SS, Fritzinger BK, Heller J. Manuscript in preparation. Merkli, 1994, Semi-solid hydrophobic bioerodible poly(ortho ester) for potential application in glaucoma filtering surgery, J Control Rel, 29, 105, 10.1016/0168-3659(94)90126-0 Nakamichi, 1983, Bovine teeth as possible substitutes in the adhesion test, J Dent Res, 62, 1076, 10.1177/00220345830620101501 Cadwell, 1971, Adhesion of restorative materials to teeth, J Dent Res, 50, 1517, 10.1177/00220345710500062601