Development of a CLDN18.2-targeting immuno-PET probe for non-invasive imaging in gastrointestinal tumors

Journal of Pharmaceutical Analysis - Tập 13 - Trang 367-375 - 2023
Yan Chen1,2, Xingguo Hou2, Dapeng Li1,2, Jin Ding2, Jiayue Liu2, Zilei Wang2,3, Fei Teng4, Hongjun Li4, Fan Zhang4, Yi Gu4, Steven Yu4, Xueming Qian4, Zhi Yang1,2,5, Hua Zhu1,2,5
1Guizhou University Medicine College, Guiyang, 550025, China
2The Ministry of Education Key Laboratory of Carcinogenesis and Translational Research; NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals, Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, 100142, China
3Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, 646000, China
4Suzhou Transcenta Therapeutics Co., Ltd, Suzhou, Jiangsu, 215127, China
5Institute of Biomedical Engineering, Peking University Shenzhen Graduate School, Shenzhen, Guangdong, 518055, China

Tài liệu tham khảo

Sung, 2021, Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, CA Cancer J. Clin., 71, 209, 10.3322/caac.21660 Cao, 2021, Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020, Chin. Med. J. (Engl.), 134, 783, 10.1097/CM9.0000000000001474 Qiu, 2021, Cancer incidence, mortality, and burden in China: A time-trend analysis and comparison with the United States and United Kingdom based on the global epidemiological data released in 2020, Cancer Commun. (Lond), 41, 1037, 10.1002/cac2.12197 Janjigian, 2021, First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): A randomised, open-label, phase 3 trial, Lancet, 398, 27, 10.1016/S0140-6736(21)00797-2 Van Cutsem, 2006, Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: A report of the V325 Study Group, J. Clin. Oncol., 24, 4991, 10.1200/JCO.2006.06.8429 Shitara, 2017, Chemotherapy for advanced gastric cancer: Future perspective in Japan, Gastric Cancer, 20, 102, 10.1007/s10120-016-0648-7 Pavel, 2020, Gastroenteropancreatic neuroendocrine neoplasms: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up, Ann. Oncol., 31, 844, 10.1016/j.annonc.2020.03.304 Shen, 2022, Anticancer drug R&D of gastrointestinal cancer in China: Current landscape and challenges, Innovation (Camb), 3 Tsukita, 2001, Multifunctional strands in tight junctions, Nat. Rev. Mol. Cell Biol., 2, 285, 10.1038/35067088 Günzel, 2013, Claudins and the modulation of tight junction permeability, Physiol. Rev., 93, 525, 10.1152/physrev.00019.2012 Otani, 2020, Tight junction structure and function revisited, Trends Cell Biol., 30, 805, 10.1016/j.tcb.2020.08.004 Tabariès, 2017, The role of claudins in cancer metastasis, Oncogene, 36, 1176, 10.1038/onc.2016.289 Hashimoto, 2022, Claudins and gastric cancer: An overview, Cancers (Basel), 14, 290, 10.3390/cancers14020290 Sahin, 2021, FAST: A randomised phase II study of zolbetuximab (IMAB362) plus EOX versus EOX alone for first-line treatment of advanced CLDN18.2-positive gastric and gastro-oesophageal adenocarcinoma, Ann. Oncol., 32, 609, 10.1016/j.annonc.2021.02.005 Gong, 2022 Qi, 2022, Claudin18.2-specific CAR T cells in gastrointestinal cancers: Phase 1 trial interim results, Nat. Med., 28, 1189, 10.1038/s41591-022-01800-8 Fan, 2021, Ultrasensitive gastric cancer circulating tumor cellular CLDN18.2 RNA detection based on a molecular beacon, Anal. Chem., 93, 665, 10.1021/acs.analchem.0c04055 Gu, 2022, Relationship of 18F-FDG PET/CT parameters and CLDN 18.2 expression status in gastric cancer, J. Nucl. Med., 63 Hu, 2022, Development and comparison of three 89Zr-labeled anti-CLDN18.2 antibodies to noninvasively evaluate CLDN18.2 expression in gastric cancer: A preclinical study, Eur. J. Nucl. Med. Mol. Imaging, 49, 2634, 10.1007/s00259-022-05739-3 Hu, 2022, Study of 89Zr-labeled recombinant antibody VHH-Fc for noninvasive evaluation of CLDN18.2 expression in gastric cancer, J. Nucl. Med., 63, 2525 Zhao, 2022, Targeting Claudin 18.2 using a highly specific antibody enables cancer diagnosis and guided surgery, Mol. Pharm., 19, 3530, 10.1021/acs.molpharmaceut.1c00947 Börjesson, 2009, Radiation dosimetry of 89Zr-labeled chimeric monoclonal antibody U36 as used for immuno-PET in head and neck cancer patients, J. Nucl. Med., 50, 1828, 10.2967/jnumed.109.065862 Laforest, 2016, [89Zr]Trastuzumab: Evaluation of radiation dosimetry, safety, and optimal imaging parameters in women with HER2-positive breast cancer, Mol. Imaging Biol., 18, 952, 10.1007/s11307-016-0951-z O'Donoghue, 2018, Pharmacokinetics, biodistribution, and radiation dosimetry for 89Zr-Trastuzumab in patients with esophagogastric cancer, J. Nucl. Med., 59, 161, 10.2967/jnumed.117.194555 England, 2017, Preclinical pharmacokinetics and biodistribution studies of 89Zr-Labeled pembrolizumab, J. Nucl. Med., 58, 162, 10.2967/jnumed.116.177857 Sobol, 2021, Immuno-PET imaging of pancreatic tumors with 89Zr-Labeled gold nanoparticle-antibody conjugates, Mol. Imag. Biol., 23, 84, 10.1007/s11307-020-01535-3 Vivier, 2019, The impact of FcγRI binding on immuno-PET, J. Nucl. Med., 60, 1174, 10.2967/jnumed.118.223636 Adumeau, 2022, Site-specific, platform-based conjugation strategy for the synthesis of dual-labeled immunoconjugates for bimodal PET/NIRF imaging of HER2-positive tumors, Bioconjug. Chem., 33, 530, 10.1021/acs.bioconjchem.2c00049 Lamberts, 2015, Antibody positron emission tomography imaging in anticancer drug development, J. Clin. Oncol., 33, 1491, 10.1200/JCO.2014.57.8278 Zhang, 2020, Evaluation and reflection on claudin 18.2 targeting therapy in advanced gastric cancer, Chin. J. Cancer Res., 32, 263, 10.21147/j.issn.1000-9604.2020.02.13