Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

Immunity - Tập 11 Số 2 - Trang 141-151 - 1999
Hiroyuki Nishimura1, Masato Nose2, Hiroshi Hiai3, Nagahiro Minato4, Tasuku Honjo1
1Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-ku, Kyoto 606-8501, Japan
2Department of Pathology, Ehime University School of Medicine, Shigenobu-cho, Onsen-gun, Ehime 791-0295, Japan
3Department of Pathology and Biology of Diseases, Faculty of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-ku, Kyoto 606-8501, Japan
4Department of Immunology and Cell Biology, Faculty of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-ku, Kyoto 606-8501, Japan

Tóm tắt

Từ khóa


Tài liệu tham khảo

Agata, 1996, Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes, Int. Immunol., 8, 765, 10.1093/intimm/8.5.765

Asano, 1988, A new T cell subset expressing B220 and CD4 in lpr mice, Clin. Exp. Immunol., 74, 36

Burshtyn, 1997, Regulation through inhibitory receptors, Trends Cell Biol., 7, 473, 10.1016/S0962-8924(97)01167-7

Cohen, 1991, Lpr and gld, Annu. Rev. Immunol., 9, 243, 10.1146/annurev.iy.09.040191.001331

Datta, 1987, Induction of a cationic shift in IgG anti-DNA autoantibodies. Role of T helper cells with classical and novel phenotypes in three murine models of lupus nephritis, J. Exp. Med., 165, 1252, 10.1084/jem.165.5.1252

Doody, 1995, A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP, Science, 269, 242, 10.1126/science.7618087

Drake, 1995, Genetic contributions to lupus-like disease in (NZB × NZW)F1 mice, Immunol. Rev., 144, 51, 10.1111/j.1600-065X.1995.tb00065.x

Finger, 1997, The human PD-1 gene, Gene, 197, 177, 10.1016/S0378-1119(97)00260-6

Goodnow, 1995, Self-tolerance checkpoints in B lymphocyte development, Adv. Immunol., 59, 279, 10.1016/S0065-2776(08)60633-1

Hibbs, 1995, Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease, Cell, 83, 301, 10.1016/0092-8674(95)90171-X

Ishida, 1992, Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death, EMBO J., 11, 3887, 10.1002/j.1460-2075.1992.tb05481.x

Izui, 1984, Induction of various autoantibodies by mutant gene lpr in several strains of mice, J. Immunol., 133, 227, 10.4049/jimmunol.133.1.227

Izui, 1995, The Yaa gene model of systemic lupus erythematosus, Immunol. Rev., 144, 137, 10.1111/j.1600-065X.1995.tb00068.x

Kappler, 1987, T cell tolerance by clonal elimination in the thymus, Cell, 49, 273, 10.1016/0092-8674(87)90568-X

Kariyone, 1988, Ontogeny and function of B220+L3T4+ T-cell subset of MRL/Mp lpr/lpr mice, Cell. Immunol., 115, 112, 10.1016/0008-8749(88)90166-9

Kawai, 1991, Induction of cutaneous graft-versus-host disease by local injection of unprimed T cells, Clin. Exp. Immunol., 84, 359, 10.1111/j.1365-2249.1991.tb08173.x

Kotzin, 1996, Systemic lupus erythematosus, Cell, 85, 303, 10.1016/S0092-8674(00)81108-3

Kranz, 1984, Immunoprecipitation of cell surface structures of cloned cytotoxic T lymphocytes by clone-specific antisera, Proc. Natl. Acad. Sci. USA, 81, 573, 10.1073/pnas.81.2.573

Ma, 1996, Autoimmune lpr/lpr mice deficient in CD40 ligand, J. Immunol., 157, 417, 10.4049/jimmunol.157.1.417

Matthews, 1992, Characterization of hematopoietic intracellular protein tyrosine phosphatases, Mol. Cell. Biol., 12, 2396

Miller, 1992, Peripheral T cell tolerance, Annu. Rev. Immunol., 10, 51, 10.1146/annurev.iy.10.040192.000411

Miller, 1994, T-cell tolerance and autoimmunity in transgenic models of central and peripheral tolerance, Curr. Opin. Immunol., 6, 892, 10.1016/0952-7915(94)90010-8

Mondino, 1996, The anatomy of T-cell activation and tolerance, Proc. Natl. Acad. Sci. USA, 93, 2245, 10.1073/pnas.93.6.2245

Murphy, 1991, Characterization of target injury of murine acute graft-versus-host disease directed to multiple minor histocompatibility antigens elicited by either CD4+ or CD8+ effector cells, Am. J. Pathol., 138, 983

Nagata, 1995, The Fas death factor, Science, 267, 1449, 10.1126/science.7533326

Nishimura, 1996, Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4-CD8-) thymocytes, Int. Immunol., 8, 773, 10.1093/intimm/8.5.773

Nishimura, 1998, Immunological studies on PD-1 deficient mice, Int. Immunol., 10, 1563, 10.1093/intimm/10.10.1563

Nishizumi, 1995, Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice, Immunity, 3, 549, 10.1016/1074-7613(95)90126-4

Nossal, 1994, Negative selection of lymphocytes, Cell, 76, 229, 10.1016/0092-8674(94)90331-X

O'Keefe, 1996, Hyperresponsive B cells in CD22-deficient mice, Science, 274, 798, 10.1126/science.274.5288.798

O'Keefe, 1999, Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies, J. Exp. Med., 189, 1307, 10.1084/jem.189.8.1307

Ono, 1996, Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB, Nature, 383, 263, 10.1038/383263a0

Otipoby, 1996, CD22 regulates thymus-independent responses and the lifespan of B cells, Nature, 384, 634, 10.1038/384634a0

Pani, 1995, Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling, J. Exp. Med., 181, 2077, 10.1084/jem.181.6.2077

Perlmutter, 1979, Immunoglobulin subclass-specific immunodeficiency in mice with an X-linked B-lymphocyte defect, J. Exp. Med., 149, 993, 10.1084/jem.149.4.993

Plutzky, 1992, Isolation of a src homology 2-containing tyrosine phosphatase, Proc. Natl. Acad. Sci. USA, 89, 1123, 10.1073/pnas.89.3.1123

Roark, 1995, Breakdown of B cell tolerance in a mouse model of systemic lupus erythematosus, J. Exp. Med., 181, 1157, 10.1084/jem.181.3.1157

Rocha, 1991, Peripheral selection of the T cell repertoire, Science, 251, 1225, 10.1126/science.1900951

Sato, 1996, CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction, Immunity, 5, 551, 10.1016/S1074-7613(00)80270-8

Scher, 1975, X-linked B-lymphocyte immune defect in CBA/HN mice. I. Studies of the function and composition of spleen cells, J. Exp. Med., 141, 788, 10.1084/jem.141.4.788

Scher, 1975, X-linked B-lymphocyte immune defect in CBA/N mice. II. Studies of the mechanisms underlying the immune defect, J. Exp. Med., 142, 637, 10.1084/jem.142.3.637

Sha, 1988, Positive and negative selection of an antigen receptor on T cells in transgenic mice, Nature, 336, 73, 10.1038/336073a0

Sha, 1988, Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice, Nature, 335, 271, 10.1038/335271a0

Shen, 1991, A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases, Nature, 352, 736, 10.1038/352736a0

Shinohara, 1994, Structure and chromosomal localization of the human PD-1 gene (PDCD1), Genomics, 23, 704, 10.1006/geno.1994.1562

Slack, 1984, Isotypes of spontaneous and mitogen-induced autoantibodies in SLE-prone mice, J. Immunol., 132, 1271, 10.4049/jimmunol.132.3.1271

Steinberg, 1983, Studies of congenic MRL-Ipr/Ipr.xid mice, J. Immunol., 131, 2789, 10.4049/jimmunol.131.6.2789

Strasser, 1991, Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease, Proc. Natl. Acad. Sci. USA, 88, 8661, 10.1073/pnas.88.19.8661

Takahashi, 1991, IgG3 production in MRL/lpr mice is responsible for development of lupus nephritis, J. Immunol., 147, 515, 10.4049/jimmunol.147.2.515

Takahashi, 1993, Cloning and cDNA sequence analysis of nephritogenic monoclonal antibodies derived from an MRL/lpr lupus mouse, Mol. Immunol., 30, 177, 10.1016/0161-5890(93)90089-T

Takai, 1996, Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice, Nature, 379, 346, 10.1038/379346a0

Theofilopoulos, 1985, Murine models of systemic lupus erythematosus, Adv. Immunol., 37, 269, 10.1016/S0065-2776(08)60342-9

Thomas, 1995, Of ITAMs and ITIMs, J. Exp. Med., 181, 1953, 10.1084/jem.181.6.1953

Vivier, 1997, Immunoreceptor tyrosine-based inhibitory motifs, Immunol. Today, 18, 286, 10.1016/S0167-5699(97)80025-4

Volc Platzer, 1988, Sequential immunohistologic analysis of the skin following allogeneic bone marrow transplantation, J. Invest. Dermatol., 91, 162, 10.1111/1523-1747.ep12464407

von Boehmer, 1990, Developmental biology of T cells in T cell-receptor transgenic mice, Annu. Rev. Immunol., 8, 531, 10.1146/annurev.iy.08.040190.002531

von Boehmer, 1991, Positive and negative selection of the alpha beta T-cell repertoire in vivo, Curr. Opin. Immunol., 3, 210, 10.1016/0952-7915(91)90052-3

Vyse, 1998, Genetic susceptibility to systemic lupus erythematosus, Annu. Rev. Immunol., 16, 261, 10.1146/annurev.immunol.16.1.261

Yi, 1992, Protein tyrosine phosphatase containing SH2 domains, Mol. Cell. Biol., 12, 836

Zhang, 1995, An immunological renal disease in transgenic mice that overexpress Fli-1, a member of the ets family of transcription factor genes, Mol. Cell. Biol., 15, 6961, 10.1128/MCB.15.12.6961