Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities

Springer Science and Business Media LLC - Tập 24 - Trang 1568-1577 - 2014
Po-Yee Chung1, Roberto Gambari2, Yi-Xin Chen3, Chor-Hing Cheng1, Zhao-Xiang Bian4, Albert Sun-Chi Chan4, Johnny Cheuk-On Tang1, Polly Hang-Mei Leung5, Chung-Hin Chui4, Kim-Hung Lam1
1State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China
2Department of Life Sciences and Biotechnology, Centre of Biotechnology, University of Ferrara, Ferrara, Italy
3Department of Chemistry, Guangzhou University, Guangzhou, China
4Clinical Division, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China
5Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China

Tóm tắt

A series of 8-benzyloxy-substituted quinoline ethers (2a–n) compounds were synthesized. All synthesized compounds were screened in vitro for their preliminary antimicrobial activities against two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), two Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and a fungal species (Aspergillus niger). Among all synthesized compounds, compound 2e showed a significant growth inhibitory activity with MIC value 3.125 μg/mL which was comparable to 8-hydroxyquinoline (2.5 μg/mL) and terbinafine (1.25 μg/mL) against A. niger.

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