Development and pharmacological evaluation of ropivacaine-2-hydroxypropyl-β-cyclodextrin inclusion complex

Araujo, 2004, Encapsulation of mepivacaine prolongs the analgesia provided by sciatic nerve blockade in mice, Can. J. Anaesth., 51, 566, 10.1007/BF03018399

Araujo, 2005, Drug-delivery systems for racemic BPV (S50-R50) and BPV enantiomeric mixture (S75-R25): cyclodextrins complexation effects on sciatic nerve blockade in mice, Rev. Bras. Anestesiol., 55, 316

Araujo, 2006, Complexation of 50% enantiomeric excess (S75-R25) bupivacaine with cyclodextrins and spinal block anesthesia in rats, Rev. Bras. Anestesiol., 56, 495

Carpenter, 1995, Safety of parenteral hydroxypropylβ-cyclodextrin, J. Pharm. Sci., 84, 222, 10.1002/jps.2600840220

Cederholm, 1997, Preliminary risk-benefit analisys of ropivacaine in labour and following surgery, Drug Saf., 16, 391, 10.2165/00002018-199716060-00005

Covino, 1976

Davis, 2004, Cyclodextrin-based pharmaceutics: past, present and future, Nat. Rev., 3, 1023, 10.1038/nrd1576

de Jong, 1994

Debouzy, 1997, Mechanism of α-cyclodextrin induced hemolysis. 2. A study of the factors controlling the association with serine-, ethanolamine-, and choline-phospholipids, J. Pharm. Sci., 87, 59, 10.1021/js970180j

Djedaïne, 1990, High-field nuclear magnetic resonance techniques for the investigation of a β-cyclodextrin:indomethacin inclusion complex, J. Pharm. Sci., 79, 643, 10.1002/jps.2600790721

Dollo, 1996, Inclusion complexation of amide-typed local anesthetics with β-cyclodextrin and its derivatives. I. Physicochemical characterization, Int. J. Pharm., 131, 219, 10.1016/0378-5173(95)04334-9

Dollo, 1996, Inclusion complexation of amide-typed local anesthetics with β-cyclodextrin and its derivatives. II. Evaluation of affinity constants and in vitro transfer rate constants, Int. J. Pharm., 131, 219, 10.1016/0378-5173(95)04334-9

Dollo, 1998, Inclusion complexation of amide-typed local anesthetics with β-cyclodextrin and its derivatives. III. Biopharmaceutics of bupivacaine-SBE7-β-CD complex following percutaneous sciatic nerve administration in rabbits, Int. J. Pharm., 164, 11, 10.1016/S0378-5173(97)00365-7

Dollo, 2000, Biopharmaceutics of local anesthetic-cyclodextrin complexes following loco-regional administration, Ann. Pharm. Fr., 58, 425

Dony, 2000, The comparative toxicicty of ropivacaine and bupivacaine at equipotent doses in rats, Anesth. Analg., 91, 1489, 10.1097/00000539-200012000-00036

Duchêne, 1987

Estebe, 2002, Bupivacaine pharmacokinetiocs and motor blockade following epidural administration of the bupivacaine- sulfobutylether -7-β-cyclodextrin complex in sheep, Eur. J. Anaesthesiol., 19, 308, 10.1097/00003643-200204000-00015

Fauvelle, 1997, Mechanism of α-cyclodextrin-induced hemolysis. 1. The two-step extraction of phosphatidylinositol from the membrane, J. Pharm. Sci., 86, 935, 10.1021/js9602453

Fraceto, 2005, Differential effects of uncharged aminoamide local anesthetics on phospholipid bilayers, as monitored by 1H NMR measurements, Biophys. Chem., 115, 11, 10.1016/j.bpc.2004.12.003

Freville, 1996, Controlled systemic absorption and increased anesthetic effect of bupivacaine following epidural administration of bupivacaine-hydroxypropyl-beta-cyclodextrin complex, Pharm. Res., 13, 1576, 10.1023/A:1016000217550

Frömming, 1994, 10.1007/978-94-015-8277-3

Gantenbein, 1997, Ketamine effects on bupivacaine local anaesthetic activity and pharmacokinetics of bupivacaine, Life Sci., 61, 2027, 10.1016/S0024-3205(97)00861-8

Gould, 2005, 2-Hydroypropyl-β-cyclodextrin (HP-β-CD): a toxicology review, Food Chem. Toxicol., 43, 1451, 10.1016/j.fct.2005.03.007

Higuchi, 1965, Phase-solubility techniques, Adv. Anal. Chem. Inst., 4, 117

Hirayama, 1999, Cyclodextrin-based controlled drug-release system, Adv. Drug Deliv. Rev., 36, 125, 10.1016/S0169-409X(98)00058-1

Irie, 1997, Pharmaceutical applications of cyclodextrins. III. Toxicological issues and safety evaluation, J. Pharm. Sci., 86, 147, 10.1021/js960213f

Karashima, 2007, Prolongation of intrathecal and sciatic nerve blocks using a complex of levobupivacaine with maltosyl-beta-cyclodextrin in rats, Anesth. Analg., 104, 1121, 10.1213/01.ane.0000260309.15034.52

Knudsen, 1997, Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers, Br. J. Anaesth., 78, 507, 10.1093/bja/78.5.507

Leszczynska, 1992, A sciatic blockade method to differentiate drug-induced local anesthesia from neuromuscular blockade in mice, J. Pharmacol. Meth., 27, 85, 10.1016/1056-8719(92)90026-W

Loftsson, 1996, Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization, J. Pharm. Sci., 85, 1017, 10.1021/js950534b

Loftsson, 2007, Cyclodextrins and their pharmaceutical applications, Int. J. Pharm., 329, 1, 10.1016/j.ijpharm.2006.10.044

Loftsson, 2005, Evaluation of cyclodextrins solubilization of drugs, Int. J. Pharm., 302, 18, 10.1016/j.ijpharm.2005.05.042

Loftsson, 2007, The complexation efficiency, J. Incl. Phenom. Macrocycl. Chem., 57, 545, 10.1007/s10847-006-9247-2

Loukas, 1998, Drugs, in cyclodextrins in liposomes: a novel approach to the chemical stability of drugs sensitive to hydrolysis, Int. J. Pharm., 162, 137, 10.1016/S0378-5173(97)00421-3

Malheiros, 2004, A new look at the hemolytic effect of local anesthetics considering their real membrane/water partitioning at pH 7.4, Biophys. Chem., 110, 213, 10.1016/j.bpc.2004.01.013

Mather, 2001, Cardiotoxicity with modern local anesthetics: is there a safer choice?, Drugs, 61, 333, 10.2165/00003495-200161030-00002

Mcclellan, 2001, Ropivacaine: an update of its use in regional anesthesia, Drugs, 60, 1065, 10.2165/00003495-200060050-00007

Moraes, 2007, Characterization of lidocaine:hydroxypropyl-β-cyclodextrin inclusion complex, J. Incl. Phenom. Macrocycl. Chem., 57, 313, 10.1007/s10847-006-9179-x

Moraes, 2007, Study of the interaction between S(−) bupivacaine and 2-hydroxypropyl-beta-cyclodextrin, Int. J. Pharm., 331, 99, 10.1016/j.ijpharm.2006.09.054

Motoyama, 2006, Effect of 2 6-di-O-methyl-alpha-cyclodextrin on hemolysis and morphological change in rabbit's red blood cells, Eur. J. Pharm. Sci., 29, 111, 10.1016/j.ejps.2006.06.002

Rajewski, 1996, Pharmaceutical applications of cyclodextrins. 2. In vivo drug delivery, J. Pharm. Sci., 85, 1142, 10.1021/js960075u

Randall, 1957, A method for measurement of analgesic activity of inflamed tissue, Arch. Int. Pharmacodyn. Ther., 409

Strichartz, 1987, Local anesthetics, 21, 10.1007/978-3-642-71110-7_2

Suwalsky, 2002, Structural effects of the local anesthetic bupivacaine hydrochloride on the human erythrocyte membrane and molecular models, Blood Cells Mol. Dis., 29, 14, 10.1006/bcmd.2002.0531

Szejtli, J., 1982. Cyclodextrin and their inclusion complexes, Academia, Kiado, Budapest, Hungary.

Szejtli, 1998, Introduction and general overview of cyclodextrin chemistry, Chem. Rev., 98, 1743, 10.1021/cr970022c

Tavornvipas, 2002, 6-O-α-(4-O-α-D-glucuronyl)-D-glucosyl-β-cyclodextrin: solubilizing ability and some cellular effects, Int. J. Pharm., 249, 199, 10.1016/S0378-5173(02)00537-9

Wang, 2001, Update on ropivacaine, Expert Opin. Pharmacother., 2, 2051, 10.1517/14656566.2.12.2051

Xiliang, 2005, Comparative study on the inclusion behavior between meso-tetrakis(4-N-ethylpyridiniurmyl)porphyrin and beta-cyclodextrin derivatives, Spectrochim. Acta A Mol. Biomol. Spectrosc., 61, 413, 10.1016/j.saa.2004.04.004