Developing zebrafish models relevant to PTSD and other trauma- and stressor-related disorders

Adam Michael Stewart1, Ester Yang2, Michael Nguyen1,3, Allan V. Kalueff1
1ZENEREI Institute and the International Zebrafish Neuroscience Research Consortium (ZNRC), 309 Palmer Court, Slidell, LA 70458, USA
2Mount Holyoke College, 50 College Street, South Hadley, MA 01075, USA
3Department of Biomedical Engineering, University of Virginia, 415 Lane Road, Charlottesville, VA 22908, USA

Tài liệu tham khảo

Ablain, 2013, Of fish and men: using zebrafish to fight human diseases, Trends Cell Biol, 23, 584, 10.1016/j.tcb.2013.09.009 Adamec, 1993, Lasting effects on rodent anxiety of a single exposure to a cat, Physiol Behav, 54, 101, 10.1016/0031-9384(93)90050-P Agetsuma, 2010, The habenula is crucial for experience-dependent modification of fear responses in zebrafish, Nat Neurosci, 13, 1354, 10.1038/nn.2654 Agetsuma, 2012, Cued fear conditioning in zebrafish (Danio rerio), 66, 257 Ahrens, 2013, Whole-brain functional imaging at cellular resolution using light-sheet microscopy, Nat Methods, 10, 413, 10.1038/nmeth.2434 Airhart, 2007, Movement disorders and neurochemical changes in zebrafish larvae after bath exposure to fluoxetine (PROZAC), Neurotoxicol Teratol, 29, 652, 10.1016/j.ntt.2007.07.005 Alazizi, 2011, Identification, characterization, and ontogenic study of a catechol O-methyltransferase from zebrafish, Aquat Toxicol, 102, 18, 10.1016/j.aquatox.2010.12.016 Aldeco, 2011, Catalytic and inhibitor binding properties of zebrafish monoamine oxidase (zMAO): comparisons with human MAO A and MAO B, Comp Biochem Physiol B Biochem Mol Biol, 159, 78, 10.1016/j.cbpb.2011.02.002 Alderman, 2009, Ontogeny of the corticotropin-releasing factor system in zebrafish, Gen Comp Endocrinol, 164, 61, 10.1016/j.ygcen.2009.04.007 Ali, 2012, Behavioral profiling of zebrafish embryos exposed to a panel of 60 water-soluble compounds, Behav Brain Res, 228, 272, 10.1016/j.bbr.2011.11.020 Alisic, 2014, Rates of post-traumatic stress disorder in trauma-exposed children and adolescents: meta-analysis, Br J Psychiatry, 204, 335, 10.1192/bjp.bp.113.131227 Alsop, 2009, The zebrafish stress axis: molecular fallout from the teleost-specific genome duplication event, Gen Comp Endocrinol, 161, 62, 10.1016/j.ygcen.2008.09.011 Anderson, 2014, Posttraumatic stress disorder and substance use disorder comorbidity among individuals with physical disabilities: findings from the National Comorbidity Survey Replication, J Trauma Stress, 27, 182, 10.1002/jts.21894 Andrade, 1997, Eye-movements and visual imagery: a working memory approach to the treatment of post-traumatic stress disorder, Br J Clin Psychol, 36, 209, 10.1111/j.2044-8260.1997.tb01408.x Avram, 2010, Frontal EEG activation asymmetry reflects cognitive biases in anxiety: evidence from an emotional face Stroop task, Appl Psychophysiol Biofeedback, 35, 285, 10.1007/s10484-010-9138-6 Baker, 2001, Plasma and cerebrospinal fluid interleukin-6 concentrations in posttraumatic stress disorder, Neuroimmunomodulation, 9, 209, 10.1159/000049028 Bangasser, 2014, Sex differences in stress-related psychiatric disorders: Neurobiological perspectives, Front Neuroendocrinol, 35, 303, 10.1016/j.yfrne.2014.03.008 Barcellos, 2007, Whole-body cortisol increases after direct and visual contact with a predator in zebrafish, Danio rerio, Aquaculture, 272, 774, 10.1016/j.aquaculture.2007.09.002 Bass, 2008, Zebrafish (Danio rerio) responds differentially to stimulus fish: the effects of sympatric and allopatric predators and harmless fish, Behav Brain Res, 186, 107, 10.1016/j.bbr.2007.07.037 Battaglia, 2013, Gene–environment interaction in panic disorder and posttraumatic stress disorder, Can J Psychiatry, 58, 69, 10.1177/070674371305800202 Bencan, 2009, Buspirone, chlordiazepoxide and diazepam effects in a zebrafish model of anxiety, Pharmacol Biochem Behav, 94, 75, 10.1016/j.pbb.2009.07.009 Bensimon, 2013, Elaboration on posttraumatic stress disorder diagnostic criteria: a factor analytic study of PTSD exposure to war or terror, Isr J Psychiatry Relat Sci, 50, 84 Berghmans, 2007, Zebrafish offer the potential for a primary screen to identify a wide variety of potential anticonvulsants, Epilepsy Res, 75, 18, 10.1016/j.eplepsyres.2007.03.015 Bird, 2005, Characterisation and expression analysis of interleukin 2 (IL-2) and IL-21 homologues in the Japanese pufferfish, Fugu rubripes, following their discovery by synteny, Immunogenetics, 56, 909, 10.1007/s00251-004-0741-7 Blanchard, 2001, Cue and context conditioning of defensive behaviors to cat odor stimuli, Neurosci Biobehav Rev, 25, 587, 10.1016/S0149-7634(01)00043-4 Blank, 2009, A one-trial inhibitory avoidance task to zebrafish: rapid acquisition of an NMDA-dependent long-term memory, Neurobiol Learn Mem, 92, 529, 10.1016/j.nlm.2009.07.001 Blaser, 2010, Behavioral measures of anxiety in zebrafish (Danio rerio), Behav Brain Res, 208, 56, 10.1016/j.bbr.2009.11.009 Boehmler, 2007, D4 dopamine receptor genes of zebrafish and effects of the antipsychotic clozapine on larval swimming behaviour, Genes Brain Behav, 6, 155, 10.1111/j.1601-183X.2006.00243.x Braida, 2012, Neurohypophyseal hormones manipulation modulate social and anxiety-related behavior in zebrafish, Psychopharmacology (Berl), 220, 319, 10.1007/s00213-011-2482-2 Bremner, 1997, Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder, Am J Psychiatry, 154, 624, 10.1176/ajp.154.5.624 Breslau, 2002, Gender differences in trauma and posttraumatic stress disorder, J Gend Specif Med, 5, 34 Brewin, 2000, Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults, J Consult Clin Psychol, 68, 748, 10.1037/0022-006X.68.5.748 Brinks, 2007, Emotion and cognition in high and low stress sensitive mouse strains: a combined neuroendocrine and behavioral study in BALB/c and C57BL/6J mice, Front Behav Neurosci, 1, 8, 10.3389/neuro.08.008.2007 Brockerhoff, 1995, A behavioral screen for isolating zebrafish mutants with visual system defects, Proc Natl Acad Sci U S A, 92, 10545, 10.1073/pnas.92.23.10545 Burgess, 2009, Unidirectional startle responses and disrupted left–right co-ordination of motor behaviors in robo3 mutant zebrafish, Genes Brain Behav, 8, 500, 10.1111/j.1601-183X.2009.00499.x Cachat, 2010, Modeling withdrawal syndrome in zebrafish, Behav Brain Res, 208, 371, 10.1016/j.bbr.2009.12.004 Cachat, 2010, Measuring behavioral and endocrine responses to novelty stress in adult zebrafish, Nat Protoc, 5, 1786, 10.1038/nprot.2010.140 Cachat, 2010, Modeling stress and anxiety in zebrafish Cachat, 2010, Video-aided analysis of zebrafish locomotion and anxiety-related behavioral responses Cachat, 2011, Modeling stress and anxiety in zebrafish, 73 Cachat, 2013, Unique and potent effects of acute ibogaine on zebrafish: the developing utility of novel aquatic models for hallucinogenic drug research, Behav Brain Res, 236, 258, 10.1016/j.bbr.2012.08.041 Caramillo, 2014, Modeling PTSD in the zebrafish: Are we there yet?, Behav Brain Res Carter, 2008, Oxytocin, vasopressin and sociality, Prog Brain Res, 170, 331, 10.1016/S0079-6123(08)00427-5 Catuzzi, 2014, Anxiety vulnerability in women: a two-hit hypothesis, Exp Neurol, 10.1016/j.expneurol.2014.01.023 Chabrol, 2013, MDMA assisted psychotherapy found to have a large effect for chronic post-traumatic stress disorder, J Psychopharmacol, 27, 865, 10.1177/0269881113495119 Chakravarty, 2013, Chronic unpredictable stress (CUS)-induced anxiety and related mood disorders in a zebrafish model: altered brain proteome profile implicates mitochondrial dysfunction, PLoS One, 8, e63302, 10.1371/journal.pone.0063302 Chanin, 2012, Assessing startle responses and their habituation in adult zebrafish, 66, 287 Chavez, 2006, A review of pharmacotherapy for PTSD, US Pharm, 11, 31 Chen, 2013, Ultrasensitive fluorescent proteins for imaging neuronal activity, Nature, 499, 295, 10.1038/nature12354 Chiu, 2013, Regulation of zebrafish sleep and arousal states: current and prospective approaches, Front Neural Circuits, 7, 58, 10.3389/fncir.2013.00058 Chung, 2013, CLARITY for mapping the nervous system, Nat Methods, 10, 508, 10.1038/nmeth.2481 Cohen, 2004, Setting apart the affected: the use of behavioral criteria in animal models of post traumatic stress disorder, Neuropsychopharmacology, 29, 1962, 10.1038/sj.npp.1300523 Colman, 2009, Effects of the synthetic estrogen, 17alpha-ethinylestradiol, on aggression and courtship behavior in male zebrafish (Danio rerio), Aquat Toxicol, 91, 346, 10.1016/j.aquatox.2008.12.001 Dal Santo, 2014, Acute restraint stress induces an imbalance in the oxidative status of the zebrafish brain, Neurosci Lett, 558, 103, 10.1016/j.neulet.2013.11.011 Daskalakis, 2013, Animal models in translational studies of PTSD, Psychoneuroendocrinology, 38, 1895, 10.1016/j.psyneuen.2013.06.006 Davenport, 2008, A rhesus monkey model of self-injury: effects of relocation stress on behavior and neuroendocrine function, Biol Psychiatry, 63, 990, 10.1016/j.biopsych.2007.10.025 de Kloet, 2008, Elevated plasma arginine vasopressin levels in veterans with posttraumatic stress disorder, J Psychiatr Res, 42, 192, 10.1016/j.jpsychires.2006.11.009 De Marco, 2013, Optogenetic elevation of endogenous glucocorticoid level in larval zebrafish, Front Neural Circuits, 7, 82, 10.3389/fncir.2013.00082 Debiec, 2006, Noradrenergic signaling in the amygdala contributes to the reconsolidation of fear memory: treatment implications for PTSD, Ann N Y Acad Sci, 1071, 521, 10.1196/annals.1364.056 Debiec, 2011, Noradrenergic enhancement of reconsolidation in the amygdala impairs extinction of conditioned fear in rats—a possible mechanism for the persistence of traumatic memories in PTSD, Depress Anxiety, 28, 186, 10.1002/da.20803 Dekel, 2014, Posttraumatic stress disorder and depressive symptoms: joined or independent sequelae of trauma?, J Psychiatr Res, 54, 64, 10.1016/j.jpsychires.2014.03.003 Diaz-Rosales, 2009, Rainbow trout interleukin-2: cloning, expression and bioactivity analysis, Fish Shellfish Immunol, 27, 414, 10.1016/j.fsi.2009.06.008 Diehle, 2014, Trauma-focused cognitive behavioral therapy or eye movement desensitization and reprocessing: what works in children with posttraumatic stress symptoms? A randomized controlled trial, Eur Child Adolesc Psychiatry Dielenberg, 1999, Habituation of the hiding response to cat odor in rats (Rattus norvegicus), J Comp Psychol, 113, 376, 10.1037/0735-7036.113.4.376 Domschke, 2012, Patho-genetics of posttraumatic stress disorder, Psychiatr Danub, 24, 267 Dooley, 2000, Zebrafish: a model system for the study of human disease, Curr Opin Genet Dev, 10, 252, 10.1016/S0959-437X(00)00074-5 Dugatkin, 2005, Zebrafish (Danio rerio) exhibit individual differences in risk-taking behavior during predator inspection, Ethol Ecol Evol, 17, 77, 10.1080/08927014.2005.9522617 Dunn, 2008, Effects of acute and chronic stressors and CRF in rat and mouse tests for depression, Ann N Y Acad Sci, 1148, 118, 10.1196/annals.1410.022 Dutton, 2006, NPY and extreme stress: lessons learned from posttraumatic, stress disorder, EXS, 213 Ebstein, 2012, The contributions of oxytocin and vasopressin pathway genes to human behavior, Horm Behav, 61, 359, 10.1016/j.yhbeh.2011.12.014 Eddins, 2010, Zebrafish provide a sensitive model of persisting neurobehavioral effects of developmental chlorpyrifos exposure: comparison with nicotine and pilocarpine effects and relationship to dopamine deficits, Neurotoxicol Teratol, 32, 99, 10.1016/j.ntt.2009.02.005 Egan, 2009, Understanding behavioral and physiological phenotypes of stress and anxiety in zebrafish, Behav Brain Res, 205, 38, 10.1016/j.bbr.2009.06.022 Elhai, 2011, Testing whether posttraumatic stress disorder and major depressive disorder are similar or unique constructs, J Anxiety Disord, 25, 404, 10.1016/j.janxdis.2010.11.003 Ellis, 2012, Distinct models of induced hyperactivity in zebrafish larvae, Brain Res, 1449, 46, 10.1016/j.brainres.2012.02.022 Engeszer, 2004, Learned social preference in zebrafish, Curr Biol, 14, 881, 10.1016/j.cub.2004.04.042 Ewald, 2009, 107 Fantegrossi, 2008, The behavioral pharmacology of hallucinogens, Biochem Pharmacol, 75, 17, 10.1016/j.bcp.2007.07.018 Feldman, 2014, Affiliation buffers stress: cumulative genetic risk in oxytocin–vasopressin genes combines with early caregiving to predict PTSD in war-exposed young children, Transl Psychiatry, 4, e370, 10.1038/tp.2014.6 Feng, 2011, Maternal separation produces lasting changes in cortisol and behavior in rhesus monkeys, Proc Natl Acad Sci U S A, 108, 14312, 10.1073/pnas.1010943108 Frijling, 2014, Efficacy of oxytocin administration early after psychotrauma in preventing the development of PTSD: study protocol of a randomized controlled trial, BMC Psychiatry, 14, 92, 10.1186/1471-244X-14-92 Gaikwad, 2011, Acute stress disrupts performance of zebrafish in the cued and spatial memory tests: the utility of fish models to study stress-memory interplay, Behav Processes, 87, 224, 10.1016/j.beproc.2011.04.004 Garrick, 2001, Stress-induced enhancement of auditory startle: an animal model of posttraumatic stress disorder, Psychiatry, 64, 346, 10.1521/psyc.64.4.346.18600 Gebauer, 2011, Effects of anxiolytics in zebrafish: similarities and differences between benzodiazepines, buspirone and ethanol, Pharmacol Biochem Behav, 99, 480, 10.1016/j.pbb.2011.04.021 Gerlai, 2010, Zebrafish antipredatory responses: a future for translational research?, Behav Brain Res, 207, 223, 10.1016/j.bbr.2009.10.008 Gerlai, 2013, Antipredatory behavior of zebrafish: adaptive function and a tool for translational research, Evol Psychol, 11, 591, 10.1177/147470491301100308 Gerlai, 2000, Drinks like a fish: zebra fish (Danio rerio) as a behavior genetic model to study alcohol effects, Pharmacol Biochem Behav, 67, 773, 10.1016/S0091-3057(00)00422-6 Gerlai, 2006, Effects of acute and chronic ethanol exposure on the behavior of adult zebrafish (Danio rerio), Pharmacol Biochem Behav, 85, 752, 10.1016/j.pbb.2006.11.010 Gerlai, 2009, Acute and chronic alcohol dose: population differences in behavior and neurochemistry of zebrafish, Genes Brain Behav, 8, 586, 10.1111/j.1601-183X.2009.00488.x Gerlai, 2009, Zebrafish (Danio rerio) responds to the animated image of a predator: towards the development of an automated aversive task, Behav Brain Res, 201, 318, 10.1016/j.bbr.2009.03.003 Geyer, 1998, Why study hallucinogenic drugs in animals?, Heffer Rev Psychedelic Res, 1, 33 Goenjian, 2012, Association of TPH1, TPH2, and 5HTTLPR with PTSD and depressive symptoms, J Affect Disord, 140, 244, 10.1016/j.jad.2012.02.015 Goldstein, 2011, Validity: definitions and applications to psychiatric research, 99 Goodson, 2000, Forebrain peptides modulate sexually polymorphic vocal circuitry, Nature, 403, 769, 10.1038/35001581 Goswami, 2013, Animal models of post-traumatic stress disorder: face validity, Front Neurosci, 7, 89, 10.3389/fnins.2013.00089 Gotovac, 2003, Flow cytometric determination of glucocorticoid receptor (GCR) expression in lymphocyte subpopulations: lower quantity of GCR in patients with post-traumatic stress disorder (PTSD), Clin Exp Immunol, 131, 335, 10.1046/j.1365-2249.2003.02075.x Green, 2012, Automated high-throughput neurophenotyping of zebrafish social behavior, J Neurosci Methods, 210, 266, 10.1016/j.jneumeth.2012.07.017 Greer, 2014, PTSD symptom reports of patients evaluated for the New Mexico Medical Cannabis Program, J Psychoactive Drugs, 46, 73, 10.1080/02791072.2013.873843 Griffiths, 2012, A zebrafish model of glucocorticoid resistance shows serotonergic modulation of the stress response, Front Behav Neurosci, 6, 68, 10.3389/fnbeh.2012.00068 Grillon, 2004, Effects of the beta-blocker propranolol on cued and contextual fear conditioning in humans, Psychopharmacology (Berl), 175, 342, 10.1007/s00213-004-1819-5 Grossman, 2010, Characterization of behavioral and endocrine effects of LSD on zebrafish, Behav Brain Res, 214, 277, 10.1016/j.bbr.2010.05.039 Hageman, 2001, Post-traumatic stress disorder: a review of psychobiology and pharmacotherapy, Acta Psychiatr Scand, 104, 411, 10.1034/j.1600-0447.2001.00237.x Hamner, 2001, Gabapentin in PTSD: a retrospective, clinical series of adjunctive therapy, Ann Clin Psychiatry, 13, 141, 10.3109/10401230109148960 Hanks, 2013, Animal models of serotonergic psychedelics, ACS Chem Neurosci, 4, 33, 10.1021/cn300138m Harvey, 2006, Cortical/hippocampal monoamines, HPA-axis changes and aversive behavior following stress and restress in an animal model of post-traumatic stress disorder, Physiol Behav, 87, 881, 10.1016/j.physbeh.2006.01.033 Heinzelmann, 2013, Epigenetic mechanisms shape the biological response to trauma and risk for PTSD: a critical review, Nurs Res Pract, 2013, 417010 Herculano, 2014, Serotonergic modulation of zebrafish behavior: towards a paradox, Prog Neuropsychopharmacol Biol Psychiatry, 55, 50, 10.1016/j.pnpbp.2014.03.008 Higashijima, 2004, Distribution of prospective glutamatergic, glycinergic, and GABAergic neurons in embryonic and larval zebrafish, J Comp Neurol, 480, 1, 10.1002/cne.20278 Hruska, 2014, Pharmacological modulation of acute trauma memories to prevent PTSD: considerations from a developmental perspective, Neurobiol Learn Mem, 10.1016/j.nlm.2014.02.001 Hurlemann, 2010, Human amygdala reactivity is diminished by the beta-noradrenergic antagonist propranolol, Psychol Med, 40, 1839, 10.1017/S0033291709992376 Ipser, 2012, Evidence-based pharmacotherapy of post-traumatic stress disorder (PTSD), Int J Neuropsychopharmacol, 15, 825, 10.1017/S1461145711001209 Iwasaki, 2013, Expression of arginine vasotocin receptors in the developing zebrafish CNS, Gene Expr Patterns, 13, 335, 10.1016/j.gep.2013.06.005 Jesuthasan, 2012, Fear, anxiety, and control in the zebrafish, Dev Neurobiol, 72, 395, 10.1002/dneu.20873 Jin, 2014, The relationship between post traumatic stress disorder and post traumatic growth: gender differences in PTG and PTSD subgroups, Soc Psychiatry Psychiatr Epidemiol, 10.1007/s00127-014-0865-5 Jones, 2007, Let sleeping zebrafish lie: a new model for sleep studies, PLoS Biol, 5, e281, 10.1371/journal.pbio.0050281 Kalueff, 2014, Modeling neuropsychiatric spectra to empower translational biological psychiatry, Behav Brain Res Kalueff, 2007, What's wrong with my mouse model? Advances and strategies in animal modeling of anxiety and depression, Behav Brain Res, 179, 1, 10.1016/j.bbr.2007.01.023 Kalueff, 2008, Domain interplay concept in animal models of neuropsychiatric disorders: a new strategy for high-throughput neurophenotyping research, Behav Brain Res, 188, 243, 10.1016/j.bbr.2007.11.011 Kalueff, 2012, Novel experimental models of hallucinogenic drug action, anxiety and depression — from fish to humans Kalueff, 2013, Towards a comprehensive catalog of zebrafish behavior 1.0, and beyond, Zebrafish, 10, 70, 10.1089/zeb.2012.0861 Kalueff, 2014, Gaining translational momentum: more zebrafish models for neuroscience research, Prog Neuropsychopharmacol Biol Psychiatry, 55, 1, 10.1016/j.pnpbp.2014.01.022 Kalueff, 2014, Zebrafish as an emerging model for studying complex brain disorders, Trends Pharmacol Sci, 35, 63, 10.1016/j.tips.2013.12.002 Kang, 2003, Post-traumatic stress disorder and chronic fatigue syndrome-like illness among Gulf War veterans: a population-based survey of 30,000 veterans, Am J Epidemiol, 157, 141, 10.1093/aje/kwf187 Kas, 2007, Genetics of behavioural domains across the neuropsychiatric spectrum; of mice and men, Mol Psychiatry, 12, 324, 10.1038/sj.mp.4001979 Kas, 2011, Advances in multidisciplinary and cross-species approaches to examine the neurobiology of psychiatric disorders, Eur Neuropsychopharmacol, 21, 532, 10.1016/j.euroneuro.2010.12.001 Kas, 2013, Assessing behavioural and cognitive domains of autism spectrum disorders in rodents: current status and, future perspectives, Psychopharmacology (Berl), 231, 1125, 10.1007/s00213-013-3268-5 Kaslin, 2001, Comparative anatomy of the histaminergic and other aminergic systems in zebrafish (Danio rerio), J Comp Neurol, 440, 342, 10.1002/cne.1390 Ke, 2013, SeeDB: a simple and morphology-preserving optical clearing agent for neuronal circuit reconstruction, Nat Neurosci, 16, 1154, 10.1038/nn.3447 Kerr, 2008, Imaging in vivo: watching the brain in action, Nat Rev Neurosci, 9, 195, 10.1038/nrn2338 Kessler, 1993, Sex and depression in the National Comorbidity Survey. I: lifetime prevalence, chronicity and recurrence, J Affect Disord, 29, 85, 10.1016/0165-0327(93)90026-G Kessler, 1995, Posttraumatic stress disorder in the National Comorbidity Survey, Arch Gen Psychiatry, 52, 1048, 10.1001/archpsyc.1995.03950240066012 Kim, 2010, Scopolamine-induced learning impairment reversed by physostigmine in zebrafish, Neurosci Res, 67, 156, 10.1016/j.neures.2010.03.003 Klee, 2011, Zebrafish: a model for the study of addiction genetics, Hum Genet, 131, 977, 10.1007/s00439-011-1128-0 Klengel, 2014, The role of DNA methylation in stress-related psychiatric disorders, Neuropharmacology, 80C, 115, 10.1016/j.neuropharm.2014.01.013 Koch, 2014, Intranasal oxytocin as strategy for medication-enhanced psychotherapy of PTSD: salience processing and fear inhibition processes, Psychoneuroendocrinology, 40, 242, 10.1016/j.psyneuen.2013.11.018 Koenen, 2011, SLC6A4 methylation modifies the effect of the number of traumatic events on risk for posttraumatic stress disorder, Depress Anxiety, 28, 639, 10.1002/da.20825 Koenig, 1994, Mental health care for older adults in the year 2020: a dangerous and avoided topic, Gerontologist, 34, 674, 10.1093/geront/34.5.674 Kofoed, 1993, Alcoholism and drug abuse in patients with PTSD, Psychiatr Q, 64, 151, 10.1007/BF01065867 Kokel, 2008, Chemobehavioural phenomics and behaviour-based psychiatric drug discovery in the zebrafish, Brief Funct Genomic Proteomic, 7, 483, 10.1093/bfgp/eln040 Kokel, 2011, Using the zebrafish photomotor response for psychotropic drug screening, Methods Cell Biol, 105, 517, 10.1016/B978-0-12-381320-6.00022-9 Kolassa, 2010, The risk of posttraumatic stress disorder after trauma depends on traumatic load and the catechol-o-methyltransferase Val(158)Met polymorphism, Biol Psychiatry, 67, 304, 10.1016/j.biopsych.2009.10.009 Koshibu, 2011, Nuclear protein phosphatase-1: an epigenetic regulator of fear memory and amygdala long-term potentiation, Neuroscience, 173, 30, 10.1016/j.neuroscience.2010.11.023 Kovacic, 2008, Platelet serotonin concentration and suicidal behavior in combat related posttraumatic stress disorder, Prog Neuropsychopharmacol Biol Psychiatry, 32, 544, 10.1016/j.pnpbp.2007.10.014 Kumsta, 2013, Oxytocin, stress and social behavior: neurogenetics of the human oxytocin system, Curr Opin Neurobiol, 23, 11, 10.1016/j.conb.2012.09.004 Labonte, 2014, Epigenetic modulation of glucocorticoid receptors in posttraumatic stress disorder, Transl Psychiatry, 4, e368, 10.1038/tp.2014.3 Laggner, 2012, Chemical informatics and target identification in a zebrafish phenotypic screen, Nat Chem Biol, 8, 144, 10.1038/nchembio.732 LaPorte, 2010, Qui non proficit, deficit: experimental models for ‘integrative’ research of affective disorders, J Affect Disord, 121, 1, 10.1016/j.jad.2009.04.010 Larson, 2006, Aggression and vasotocin are associated with dominant–subordinate relationships in zebrafish, Behav Brain Res, 167, 94, 10.1016/j.bbr.2005.08.020 Lau, 2006, Dissociation of food and opiate preference by a genetic mutation in zebrafish, Genes Brain Behav, 5, 497, 10.1111/j.1601-183X.2005.00185.x Lee, 2013, Cardiovascular risk assessment of atypical antipsychotic drugs in a zebrafish model, J Appl Toxicol, 33, 466, 10.1002/jat.1768 Lim, 2005, Neuropeptides and the social brain: potential rodent models of autism, Int J Dev Neurosci, 23, 235, 10.1016/j.ijdevneu.2004.05.006 Lin, 2007, Acute phase response in zebrafish upon Aeromonas salmonicida and Staphylococcus aureus infection: striking similarities and obvious differences with mammals, Mol Immunol, 44, 295, 10.1016/j.molimm.2006.03.001 Ljunggren, 2014, Optogenetic activation of excitatory premotor interneurons is sufficient to generate coordinated locomotor activity in larval zebrafish, J Neurosci, 34, 134, 10.1523/JNEUROSCI.4087-13.2014 Lopez Patino, 2008, Gender differences in zebrafish responses to cocaine withdrawal, Physiol Behav, 95, 36, 10.1016/j.physbeh.2008.03.021 Lopez-Patino, 2008, Anxiogenic effects of cocaine withdrawal in zebrafish, Physiol Behav, 93, 160, 10.1016/j.physbeh.2007.08.013 Lopez-Sola, 2014, Prevalence and heritability of obsessive–compulsive spectrum and anxiety disorder symptoms: a survey of the Australian Twin Registry, Am J Med Genet B Neuropsychiatr Genet, 165B, 314, 10.1002/ajmg.b.32233 Mahabir, 2013, Maturation of shoaling in two zebrafish strains: a behavioral and neurochemical analysis, Behav Brain Res, 247, 1, 10.1016/j.bbr.2013.03.013 Mann, 2010, Cardiac response to startle stimuli in larval zebrafish: sympathetic and parasympathetic components, Am J Physiol Regul Integr Comp Physiol, 298, R1288, 10.1152/ajpregu.00302.2009 Martel, 2012, Murine GRPR and stathmin control in opposite directions both cued fear extinction and neural activities of the amygdala and prefrontal cortex, PLoS One, 7, 10.1371/journal.pone.0030942 Matar, 2013, Translationally relevant modeling of PTSD in rodents, Cell Tissue Res, 354, 127, 10.1007/s00441-013-1687-6 Mathur, 2011, Preference for ethanol in zebrafish following a single exposure, Behav Brain Res, 217, 128, 10.1016/j.bbr.2010.10.015 Maurer, 2011, Application of zebrafish oculomotor behavior to model human disorders, Rev Neurosci, 22, 5, 10.1515/rns.2011.003 Maximino, 2010, Measuring anxiety in zebrafish: a critical review, Behav Brain Res, 214, 157, 10.1016/j.bbr.2010.05.031 Maximino, 2011, Pharmacological analysis of zebrafish (Danio rerio) scototaxis, Prog Neuropsychopharmacol Biol Psychiatry, 35, 624, 10.1016/j.pnpbp.2011.01.006 Maximino, 2013, Role of serotonin in zebrafish (Danio rerio) anxiety: relationship with serotonin levels and effect of buspirone, WAY 100635, SB 224289, fluoxetine and para-chlorophenylalanine (pCPA) in two behavioral models, Neuropharmacology, 71, 83, 10.1016/j.neuropharm.2013.03.006 McGonigle, 2014, Animal models of human disease: challenges in enabling translation, Biochem Pharmacol, 87, 162, 10.1016/j.bcp.2013.08.006 McGrath, 2008, Zebrafish: a predictive model for assessing drug-induced toxicity, Drug Discov Today, 13, 394, 10.1016/j.drudis.2008.03.002 McLean, 2011, Gender differences in anxiety disorders: prevalence, course of illness, comorbidity and burden of illness, J Psychiatr Res, 45, 1027, 10.1016/j.jpsychires.2011.03.006 Meewisse, 2007, Cortisol and post-traumatic stress disorder in adults: systematic review and meta-analysis, Br J Psychiatry, 191, 387, 10.1192/bjp.bp.106.024877 Mehta, 2012, Gene×environment vulnerability factors for PTSD: the HPA-axis, Neuropharmacology, 62, 654, 10.1016/j.neuropharm.2011.03.009 Miller, 2007, Quantification of shoaling behaviour in zebrafish (Danio rerio), Behav Brain Res, 184, 157, 10.1016/j.bbr.2007.07.007 Miller, 2008, Oscillations in shoal cohesion in zebrafish (Danio rerio), Behav Brain Res, 193, 148, 10.1016/j.bbr.2008.05.004 Miller, 2011, Shoaling in zebrafish: what we don't know, Rev Neurosci, 22, 17, 10.1515/rns.2011.004 Miller, 2012, From schooling to shoaling: patterns of collective motion in zebrafish (Danio rerio), PLoS One, 7, e48865, 10.1371/journal.pone.0048865 Miller, 2013, Effects of nicotine and alcohol on zebrafish (Danio rerio) shoaling, Behav Brain Res, 240, 192, 10.1016/j.bbr.2012.11.033 Mithoefer, 2013, Durability of improvement in post-traumatic stress disorder symptoms and absence of harmful effects or drug dependency after 3,4-methylenedioxymethamphetamine-assisted psychotherapy: a prospective long-term follow-up study, J Psychopharmacol, 27, 28, 10.1177/0269881112456611 Monk, 2012, Linking prenatal maternal adversity to developmental outcomes in infants: the role of epigenetic pathways, Dev Psychopathol, 24, 1361, 10.1017/S0954579412000764 Morin, 2013, Active avoidance learning in zebrafish (Danio rerio)—the role of sensory modality and inter-stimulus interval, Behav Brain Res, 248, 141, 10.1016/j.bbr.2013.04.009 Moscovitch, 2011, Frontal EEG asymmetry and symptom response to cognitive behavioral therapy in patients with social anxiety disorder, Biol Psychol, 87, 379, 10.1016/j.biopsycho.2011.04.009 Murphy, 1986, Trends in depression and anxiety: men and women, Acta Psychiatr Scand, 73, 113, 10.1111/j.1600-0447.1986.tb10576.x Myhr, 1998, Autism and other pervasive developmental disorders: exploring the dimensional view, Can J Psychiatry, 43, 589, 10.1177/070674379804300607 Nam, 2004, NMDA receptor-dependent long-term potentiation in the telencephalon of the zebrafish, Neurosci Lett, 370, 248, 10.1016/j.neulet.2004.08.037 Neelkantan, 2013, Perspectives on zebrafish models of hallucinogenic drugs and related psychotropic compounds, ACS Chem Neurosci, 4, 1137, 10.1021/cn400090q Nestler, 2010, Animal models of neuropsychiatric disorders, Nat Neurosci, 13, 1161, 10.1038/nn.2647 Neumann, 2012, Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors, Trends Neurosci, 35, 649, 10.1016/j.tins.2012.08.004 Nguyen, 2013, Developing ‘integrative’ zebrafish models of behavioral and metabolic disorders, Behav Brain Res, 256, 172, 10.1016/j.bbr.2013.08.012 Nichols, 2004, Hallucinogens, Pharmacol Ther, 101, 131, 10.1016/j.pharmthera.2003.11.002 Ninkovic, 2006, Genetic identification of AChE as a positive modulator of addiction to the psychostimulant D-amphetamine in zebrafish, J Neurobiol, 66, 463, 10.1002/neu.20231 Nutt, 2013, Effects of schedule I drug laws on neuroscience research and treatment innovation, Nat Rev Neurosci, 14, 577, 10.1038/nrn3530 Oehen, 2013, A randomized, controlled pilot study of MDMA (+/−3,4-methylenedioxymethamphetamine)-assisted psychotherapy for treatment of resistant, chronic post-traumatic stress disorder (PTSD), J Psychopharmacol, 27, 40, 10.1177/0269881112464827 Okamoto, 2012, Genetic dissection of the zebrafish habenula, a possible switching board for selection of behavioral strategy to cope with fear and anxiety, Dev Neurobiol, 72, 386, 10.1002/dneu.20913 Olff, 2007, Gender differences in posttraumatic stress disorder, Psychol Bull, 133, 183, 10.1037/0033-2909.133.2.183 Olff, 2009, The structure of acute posttraumatic stress symptoms: ‘reexperiencing’, ‘active avoidance’, ‘dysphoria’, and ‘hyperarousal’, J Anxiety Disord, 23, 656, 10.1016/j.janxdis.2009.02.003 Olff, 2010, A psychobiological rationale for oxytocin in the treatment of posttraumatic stress disorder, CNS Spectr, 15, 522, 10.1017/S109285290000047X Olff, 2014, Executive function in posttraumatic stress disorder (PTSD) and the influence of comorbid depression, Neurobiol Learn Mem, 14, 577 Oliveira, 2011, Fighting zebrafish: characterization of aggressive behavior and winner–loser effects, Zebrafish, 8, 73, 10.1089/zeb.2011.0690 Ostrowski, 2014, Prospects for the pharmacological prevention of post-traumatic stress in vulnerable individuals, CNS Drugs, 28, 195, 10.1007/s40263-014-0145-7 Pan, 2011, Chronic alcohol exposure induced gene expression changes in the zebrafish brain, Behav Brain Res, 216, 66, 10.1016/j.bbr.2010.07.017 Panier, 2013, Fast functional imaging of multiple brain regions in intact zebrafish larvae using selective plane illumination microscopy, Front Neural Circuits, 7, 65, 10.3389/fncir.2013.00065 Parker, 2012, Genome-wide association for fear conditioning in an advanced intercross mouse line, Behav Genet, 42, 437, 10.1007/s10519-011-9524-8 Parker, 2014, The utility of zebrafish to study the mechanisms by which ethanol affects social behavior and anxiety during early brain development, Prog Neuropsychopharmacol Biol Psychiatry, 55, 94, 10.1016/j.pnpbp.2014.03.011 Parrott, 2007, The psychotherapeutic potential of MDMA (3,4-methylenedioxymethamphetamine): an evidence-based review, Psychopharmacology (Berl), 191, 181, 10.1007/s00213-007-0703-5 Passie, 2012, Mitigation of post-traumatic stress symptoms by Cannabis resin: a review of the clinical and neurobiological evidence, Drug Test Anal, 4, 649, 10.1002/dta.1377 Peskind, 2003, Prazosin reduces trauma-related nightmares in older men with chronic posttraumatic stress disorder, J Geriatr Psychiatry Neurol, 16, 165, 10.1177/0891988703256050 Pham, 2012, Assessing social behavior phenotypes in adult zebrafish: shoaling, social preference and mirror biting tests Philpott, 2012, Reducing the noise in behavioral assays: sex and age in adult zebrafish locomotion, Zebrafish, 9, 191, 10.1089/zeb.2012.0764 Piato, 2011, Unpredictable chronic stress model in zebrafish (Danio rerio): behavioral and physiological responses, Prog Neuropsychopharmacol Biol Psychiatry, 35, 561, 10.1016/j.pnpbp.2010.12.018 Piato, 2011, Acute restraint stress in zebrafish: behavioral parameters and purinergic signaling, Neurochem Res, 36, 1876, 10.1007/s11064-011-0509-z Pietrzak, 2014, Typologies of posttraumatic stress disorder in the U.S. adult population, J Affect Disord, 162, 102, 10.1016/j.jad.2014.03.024 Pigott, 1999, Gender differences in the epidemiology and treatment of anxiety disorders, J Clin Psychiatry, 60, 4 Pitman, 2005, Conceptually driven pharmacologic approaches to acute trauma, CNS Spectr, 10, 99, 10.1017/S109285290001943X Pivac, 2007, Monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity in combat-related posttraumatic stress disorder, J Affect Disord, 103, 131, 10.1016/j.jad.2007.01.017 Portugues, 2013, Optogenetics in a transparent animal: circuit function in the larval zebrafish, Curr Opin Neurobiol, 23, 119, 10.1016/j.conb.2012.11.001 Pradel, 2000, Involvement of L1.1 in memory consolidation after active avoidance conditioning in zebrafish, J Neurobiol, 43, 389, 10.1002/1097-4695(20000615)43:4<389::AID-NEU7>3.0.CO;2-X Quevedo, 1997, Involvement of mechanisms dependent on NMDA receptors, nitric oxide and protein kinase A in the hippocampus but not in the caudate nucleus in memory, Behav Pharmacol, 8, 713, 10.1097/00008877-199712000-00006 Qureshi, 2011, Does PTSD impair cognition beyond the effect of trauma?, J Neuropsychiatry Clin Neurosci, 23, 16, 10.1176/appi.neuropsych.23.1.16 Raboni, 2014, Improvement of mood and sleep alterations in posttraumatic stress disorder patients by eye movement desensitization and reprocessing, Front Behav Neurosci, 8, 209, 10.3389/fnbeh.2014.00209 Ralevski, 2014, PTSD and comorbid AUD: a review of pharmacological and alternative treatment options, Subst Abuse Rehabil, 5, 25 Ramsay, 2006, Whole-body cortisol is an indicator of crowding stress in adult zebrafish, Danio rerio, Aquaculture, 258, 565, 10.1016/j.aquaculture.2006.04.020 Rasmussen, 2008, Acoustic startle amplitude predicts vulnerability to develop post-traumatic stress hyper-responsivity and associated plasma corticosterone changes in rats, Psychoneuroendocrinology, 33, 282, 10.1016/j.psyneuen.2007.11.010 Ray, 2010, Psychedelics and the human receptorome, PLoS One, 5, e9019, 10.1371/journal.pone.0009019 Renier, 2007, Genomic and functional conservation of sedative–hypnotic targets in the zebrafish, Pharmacogenet Genomics, 17, 237, 10.1097/FPC.0b013e3280119d62 Renninger, 2011, Investigating the genetics of visual processing, function and behaviour in zebrafish, Neurogenetics, 12, 97, 10.1007/s10048-011-0273-x Ressler, 2011, Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor, Nature, 470, 492, 10.1038/nature09856 Richetti, 2011, Quercetin and rutin prevent scopolamine-induced memory impairment in zebrafish, Behav Brain Res, 217, 10, 10.1016/j.bbr.2010.09.027 Rihel, 2010, Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation, Science, 327, 348, 10.1126/science.1183090 Rojas, 2014, Understanding PTSD comorbidity and suicidal behavior: associations among histories of alcohol dependence, major depressive disorder, and suicidal ideation and attempts, J Anxiety Disord, 28, 318, 10.1016/j.janxdis.2014.02.004 Roth, 2011, Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of post-traumatic stress disorder, J Psychiatr Res, 45, 919, 10.1016/j.jpsychires.2011.01.013 Ruhl, 2005, The effect of sex and shoal size on shoaling behaviour in Danio rerio, J Fish Biol, 67, 1318, 10.1111/j.0022-1112.2005.00826.x Rusiecki, 2012, DNA methylation in repetitive elements and post-traumatic stress disorder: a case–control study of US military service members, Epigenomics, 4, 29, 10.2217/epi.11.116 Rusiecki, 2013, PTSD and DNA methylation in select immune function gene promoter regions: a repeated measures case–control study of U.S. Military service members, Front Psychiatry, 4, 56, 10.3389/fpsyt.2013.00056 Sackerman, 2010, Zebrafish behavior in novel environments: effects of acute exposure to anxiolytic compounds and choice of Danio rerio line, Int J Comp Psychol, 23, 43, 10.46867/IJCP.2010.23.01.06 Sah, 2013, Neuropeptide Y and posttraumatic stress disorder, Mol Psychiatry, 18, 646, 10.1038/mp.2012.101 Saverino, 2008, The social zebrafish: behavioral responses to conspecific, heterospecific, and computer animated fish, Behav Brain Res, 191, 77, 10.1016/j.bbr.2008.03.013 Savio, 2012, Behavioral changes induced by long-term proline exposure are reversed by antipsychotics in zebrafish, Prog Neuropsychopharmacol Biol Psychiatry, 36, 258, 10.1016/j.pnpbp.2011.10.002 Schaaf, 2008, Discovery of a functional glucocorticoid receptor β-isoform in zebrafish, Endocrinology, 149, 1591, 10.1210/en.2007-1364 Seibt, 2009, Typical and atypical antipsychotics alter acetylcholinesterase activity and ACHE expression in zebrafish (Danio rerio) brain, Comp Biochem Physiol C Toxicol Pharmacol, 150, 10, 10.1016/j.cbpc.2009.01.008 Seibt, 2010, Antipsychotic drugs prevent the motor hyperactivity induced by psychotomimetic MK-801 in zebrafish (Danio rerio), Behav Brain Res, 214, 417, 10.1016/j.bbr.2010.06.014 Seibt, 2011, Antipsychotic drugs reverse MK-801-induced cognitive and social interaction deficits in zebrafish (Danio rerio), Behav Brain Res, 224, 135, 10.1016/j.bbr.2011.05.034 Shapiro, 2001, Enhancing self-belief with EMDR: developing a sense of mastery in the early phase of treatment, Am J Psychother, 55, 531, 10.1176/appi.psychotherapy.2001.55.4.531 Sherin, 2011, Post-traumatic stress disorder: the neurobiological impact of psychological trauma, Dialogues Clin Neurosci, 13, 263, 10.31887/DCNS.2011.13.2/jsherin Shimada, 2012, A high-throughput fluorescence-based assay system for appetite-regulating gene and drug screening, PLoS One, 7, e52549, 10.1371/journal.pone.0052549 Shvil, 2014, Sex differences in extinction recall in posttraumatic stress disorder: a pilot fMRI study, Neurobiol Learn Mem, 10.1016/j.nlm.2014.02.003 Sigurgeirsson, 2011, Effects of modafinil on sleep–wake cycles in larval zebrafish, Zebrafish, 8, 133, 10.1089/zeb.2011.0708 Sison, 2011, Behavioral performance altering effects of MK-801 in zebrafish (Danio rerio), Behav Brain Res, 220, 331, 10.1016/j.bbr.2011.02.019 Sison, 2011, Associative learning performance is impaired in zebrafish (Danio rerio) by the NMDA-R antagonist MK-801, Neurobiol Learn Mem, 96, 230, 10.1016/j.nlm.2011.04.016 Smith, 2011, Differential immune system DNA methylation and cytokine regulation in post-traumatic stress disorder, Am J Med Genet B Neuropsychiatr Genet, 156B, 700, 10.1002/ajmg.b.31212 Smith, 2014, From Hofmann to the Haight Ashbury, and into the future: the past and potential of lysergic acid diethlyamide, J Psychoactive Drugs, 46, 3, 10.1080/02791072.2014.873684 Soeter, 2011, Disrupting reconsolidation: pharmacological and behavioral manipulations, Learn Mem, 18, 357, 10.1101/lm.2148511 Sondergaard, 2004, The inflammatory markers C-reactive protein and serum amyloid A in refugees with and without posttraumatic stress disorder, Clin Chim Acta, 342, 93, 10.1016/j.cccn.2003.12.019 Song, 2007, Disturbance of serum interleukin-2 and interleukin-8 levels in posttraumatic and non-posttraumatic stress disorder earthquake survivors in northern China, Neuroimmunomodulation, 14, 248, 10.1159/000112050 Speedie, 2008, Alarm substance induced behavioral responses in zebrafish (Danio rerio), Behav Brain Res, 188, 168, 10.1016/j.bbr.2007.10.031 Stamou, 2013, Neuronal connectivity as a convergent target of gene–environment interactions that confer risk for Autism Spectrum Disorders, Neurotoxicol Teratol, 36, 3, 10.1016/j.ntt.2012.12.001 Stankovic, 2012, Autism and autistic spectrum disorders in the context of new DSM-V classification, and clinical and epidemiological data, Srp Arh Celok Lek, 140, 236, 10.2298/SARH1204236S Steenbergen, 2011, The use of the zebrafish model in stress research, Prog Neuropsychopharmacol Biol Psychiatry, 35, 1432, 10.1016/j.pnpbp.2010.10.010 Stewart, 2013, Controlled substances and innovation of biomedicine: a preclinical perspective, Nat Rev Neurosci, 14, 877, 10.1038/nrn3530-c1 Stewart, 2014, Anxiolytic drug discovery: what are the novel approaches and how can we improve them?, Expert Opin Drug Discov, 9, 15, 10.1517/17460441.2014.857309 Stewart, 2014, Developing better and more valid animal models of brain disorders, Behav Brain Res Stewart, 2010, The developing utility of zebrafish in modeling neurobehavioral disorders, Int J Comp Psychol, 23, 104, 10.46867/IJCP.2010.23.01.01 Stewart, 2011, Zebrafish models to study drug abuse-related phenotypes, Rev Neurosci, 22, 95, 10.1515/rns.2011.011 Stewart, 2011, Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models, Prog Neuropsychopharmacol Biol Psychiatry, 35, 1421, 10.1016/j.pnpbp.2010.11.035 Stewart, 2012, Modeling anxiety using adult zebrafish: a conceptual review, Neuropharmacology, 62, 135, 10.1016/j.neuropharm.2011.07.037 Stewart, 2012, Constructing the habituome for phenotype-driven zebrafish research, Behav Brain Res, 236C, 110 Stewart, 2013, Perspectives on experimental models of serotonin syndrome in zebrafish, Neurochem Int, 62, 893, 10.1016/j.neuint.2013.02.018 Stewart, 2014, Zebrafish models for translational neuroscience research: from tank to bedside, Trends Neurosci, 37, 264, 10.1016/j.tins.2014.02.011 Stewart, 2014, Developing zebrafish models of autism spectrum disorder (ASD), Prog Neuropsychopharmacol Biol Psychiatry, 50, 27, 10.1016/j.pnpbp.2013.11.014 Su, 2009, Levels of the potential biomarker p11 in peripheral blood cells distinguish patients with PTSD from those with other major psychiatric disorders, J Psychiatr Res, 43, 1078, 10.1016/j.jpsychires.2009.03.010 Swain, 2004, Effects of dizocilpine (MK-801) on circling behavior, swimming activity, and place preference in zebrafish (Danio rerio), Neurotoxicol Teratol, 26, 725, 10.1016/j.ntt.2004.06.009 Szklarczyk, 2012, Genotype-dependent consequences of traumatic stress in four inbred mouse strains, Genes Brain Behav, 10.1111/j.1601-183X.2012.00850.x Taylor, 2002, The alpha1-adrenergic antagonist prazosin improves sleep and nightmares in civilian trauma posttraumatic stress disorder, J Clin Psychopharmacol, 22, 82, 10.1097/00004714-200202000-00013 Taylor, 2006, Daytime prazosin reduces psychological distress to trauma specific cues in civilian trauma posttraumatic stress disorder, Biol Psychiatry, 59, 577, 10.1016/j.biopsych.2005.09.023 Teitler, 1990, Receptor pharmacology of MDMA and related hallucinogens, Ann N Y Acad Sci, 600, 626, 10.1111/j.1749-6632.1990.tb16915.x Thoma, 2013, Empathy and social problem solving in alcohol dependence, mood disorders and selected personality disorders, Neurosci Biobehav Rev, 37, 448, 10.1016/j.neubiorev.2013.01.024 Thompson, 2004, Peptide effects on social behavior: effects of vasotocin and isotocin on social approach behavior in male goldfish (Carassius auratus), Behav Neurosci, 118, 620, 10.1037/0735-7044.118.3.620 Tian, 2010, Effects of histone deacetylase inhibitor Trichostatin A on epigenetic changes and transcriptional activation of Bdnf promoter 1 by rat hippocampal neurons, Ann N Y Acad Sci, 1199, 186, 10.1111/j.1749-6632.2009.05175.x Tipps, 2013, Substance abuse, memory, and post-traumatic stress disorder, Neurobiol Learn Mem, 112, 87, 10.1016/j.nlm.2013.12.002 Tolin, 2006, Sex differences in trauma and posttraumatic stress disorder: a quantitative review of 25years of research, Psychol Bull, 132, 959, 10.1037/0033-2909.132.6.959 Tran, 2013, Time-course of behavioural changes induced by ethanol in zebrafish (Danio rerio), Behav Brain Res, 252, 204, 10.1016/j.bbr.2013.05.065 Tran, 2013, Individual differences in activity levels in zebrafish (Danio rerio), Behav Brain Res, 257, 224, 10.1016/j.bbr.2013.09.040 Twenge, 2000, The age of anxiety? Birth cohort change in anxiety and neuroticism, 1952–1993, J Pers Soc Psychol, 79, 1007, 10.1037/0022-3514.79.6.1007 Tyler Boden, 2014, Coping among military veterans with PTSD in substance use disorder treatment, J Subst Abuse Treat, 47, 160, 10.1016/j.jsat.2014.03.006 Tyrka, 2011 Uddin, 2010, Epigenetic and immune function profiles associated with posttraumatic stress disorder, Proc Natl Acad Sci U S A, 107, 9470, 10.1073/pnas.0910794107 Uddin, 2011, Gene expression and methylation signatures of MAN2C1 are associated with PTSD, Dis Markers, 30, 111, 10.1155/2011/513659 Ursano, 2007, Models of PTSD and traumatic stress: the importance of research from bedside to bench to bedside, 167, 203 Vaiva, 2006, Relationship between posttrauma GABA plasma levels and PTSD at 1-year follow-up, Am J Psychiatry, 163, 1446, 10.1176/appi.ajp.163.8.1446 Valente, 2011, Catechol-O-methyltransferase (COMT) val158met polymorphism as a risk factor for PTSD after urban violence, J Mol Neurosci, 43, 516, 10.1007/s12031-010-9474-2 Varela, 2012, Characterisation, expression and ontogeny of interleukin-6 and its receptors in zebrafish (Danio rerio), Dev Comp Immunol, 37, 97, 10.1016/j.dci.2011.11.004 Vital, 2013, Socially-central zebrafish influence group behavior more than those on the social periphery, PLoS One, 8, e55503, 10.1371/journal.pone.0055503 Warner, 2013, Identifying and managing posttraumatic stress disorder, Am Fam Physician, 88, 827 Waugh, 2014, Fluoxetine prevents dystrophic changes in a zebrafish model of Duchenne muscular dystrophy, Hum Mol Genet, 23, 4651, 10.1093/hmg/ddu185 Wen, 2012, Validation of visualized transgenic zebrafish as a high throughput model to assay bradycardia related cardio toxicity risk candidates, J Appl Toxicol, 32, 834, 10.1002/jat.2755 Wenner, 2009, The most transparent research, Nat Med, 15, 1106, 10.1038/nm1009-1106 White, 2008, Transparent adult zebrafish as a tool for in vivo transplantation analysis, Cell Stem Cell, 2, 183, 10.1016/j.stem.2007.11.002 Winkelman, 1991, Therapeutic effects of hallucinogens, Anthropol Conscious, 2, 15, 10.1525/ac.1991.2.3-4.15 Wong, 2010, Analyzing habituation responses to novelty in zebrafish (Danio rerio), Behav Brain Res, 208, 450, 10.1016/j.bbr.2009.12.023 Xu, 1992, N-methyl-D-aspartate receptor antagonist MK-801 impairs learning but not memory fixation or expression of classical fear conditioning in goldfish (Carassius auratus), Behav Neurosci, 106, 307, 10.1037/0735-7044.106.2.307 Xu, 1998, Comparison of the amnestic effects of NMDA receptor antagonist MK-801 and nitric oxide synthase inhibitors: L-NAME and L-NOARG in goldfish, Behav Neurosci, 112, 892, 10.1037/0735-7044.112.4.892 Xu, 2007, Active avoidance conditioning in zebrafish (Danio rerio), Neurobiol Learn Mem, 87, 72, 10.1016/j.nlm.2006.06.002 Yehuda, 2001, Biology of posttraumatic stress disorder, J Clin Psychiatry, 17, 41 Yehuda, 1996, Cortisol regulation in posttraumatic stress disorder and major depression: a chronobiological analysis, Biol Psychiatry, 40, 79, 10.1016/0006-3223(95)00451-3 Yehuda, 2014, Lower methylation of glucocorticoid receptor gene promoter 1 in peripheral blood of veterans with posttraumatic stress disorder, Biol Psychiatry Yokogawa, 2007, Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants, PLoS Biol, 5, e277, 10.1371/journal.pbio.0050277 Zakhary, 2011, A behavioral and molecular analysis of ketamine in zebrafish, Synapse, 65, 160, 10.1002/syn.20830 Zhang, 2012, An optical platform for cell tracking in adult zebrafish, Cytometry A, 81, 176, 10.1002/cyto.a.21167 Zhdanova, 2011, Sleep and its regulation in zebrafish, Rev Neurosci, 22, 27, 10.1515/rns.2011.005 Zhu, 2009, Optogenetic dissection of neuronal circuits in zebrafish using viral gene transfer and the Tet system, Front Neural Circuits, 3, 21, 10.3389/neuro.04.021.2009 Ziv, 2013, An affective disorder in zebrafish with mutation of the glucocorticoid receptor, Mol Psychiatry, 18, 681, 10.1038/mp.2012.64 Zovkic, 2013, Epigenetic mechanisms in learned fear: implications for PTSD, Neuropsychopharmacology, 38, 77, 10.1038/npp.2012.79