Detoxification of cyclophosphamide by human aldehyde dehydrogenase isozymes

Agarwal, 1989, ‘High-Km’ aldehyde dehydrogenase isozymes in human tissues: constitutive and tumor associated forms, 119 Agarwal, 1990 Borch, 1984, In situ preparation and fate of cis-4-hydroxycyclophosphamide and aldophosphamide: 1H and 31P NMR evidence for equilibration of cis- and trans-4-hydroxycyclophosphamide with aldophosphamide and its hydrate in aqueous solution, J. Med. Chem., 27, 490, 10.1021/jm00370a010 Dockham, 1992, Identification of human liver aldehyde dehydrogenases that catalyze the oxidation of aldophosphamide and retinaldehyde, Biochem. Pharmacol., 43, 2453, 10.1016/0006-2952(92)90326-E Eckey, 1990, Biochemical, immunological and molecular characterization of a ‘high Km’ aldehyde dehydrogenase, 43 Hill, 1973, Metabolism of phosphamide (2-(2-chloroethylamino)-3(2-chloroethyl)-tetrahydro 2H-1,3,2,-oxazaphosphorine 2-oxide) and production of a toxic phosphamide metabolite, Cancer Res., 33, 1016 Kastan, 1990, Direct demonstration of elevated aldehyde dehydrogenase in human hematopoietic progenitor cells, Blood, 75, 1947, 10.1182/blood.V75.10.1947.1947 Lin, 1987, Role of aldehyde dehydrogenase activity in cyclophosphamide metabolism in rat lines, Biochem. Pharmacol., 36, 3305, 10.1016/0006-2952(87)90649-6 Lindahl, 1992, Aldehyde dehydrogenases and carcinogenesis, Crit. Rev. Biochem. Mol. Biol., 27, 283, 10.3109/10409239209082565 Macart, 1982, An improvement blue dye binding method allowing an equal sensitivity to various proteins: application to cerebrospinal fluid, Clin. Chim. Acta, 122, 93, 10.1016/0009-8981(82)90100-0 Manthey, 1990, Identification of the mouse aldehyde dehydrogenases important in aldophosphamide detoxification, Cancer Res., 50, 4991 Meier-Tackmann, 1993, Tumor-associated aldehyde dehydrogenase (ALDH3): expression in different human tumor cell lines with and without treatment with 3-methylcholanthrene, 115 Moreb, 1992, Role of aldehyde dehydrogenase in the protection of hematopoietic progenitor cells from 4-hydroperoxycyclophosphamide by interleukin 1β and tumor necrosis factor, Cancer Res., 52, 1770 Niemeyer, 1989, Mafosfamide: a derivative of 4-hydroxycyclo-phosphamide, Prog. Clin. Biochem. Med., 9, 35, 10.1007/978-3-642-74734-2_2 Sladek, 1990, Human and mouse hepatic aldehyde dehydrogenases important in the biotransformation of cyclophosphamide and the retinoids, 97 Sreerama, 1993, Identification and characterization of a novel class 3 aldehyde dehydrogenase overexpressed in a human breast adenocarcinoma cell line exhibiting oxazaphosphorine-specific acquired resistance, Biochem. Pharmacol., 45, 2487, 10.1016/0006-2952(93)90231-K Yoshida, 1993, Enhanced transcription of the cytosolic ALDH gene in cyclosphosphamide resistant human carcinoma cells, 63