Determination of phytochemical composition, cytotoxicity, genotoxicity and mutagenicity of the hydroethanolic extract of Dolichandra unguis-cati L. leaves in human leukocytes

Aboutabl, 2008, Flavonoids, anti-nflammatory activity and cytotoxicity of Macfadyena uniguis-cati L, Afr. J. Tradit. Complement. Altern. Med., 5, 18, 10.4314/ajtcam.v5i1.31251 Agostini-Costa, 1999, Avaliação de metodologias para determinação de taninos no suco de caju, Boletim CEPPA, 17, 167 Araldi, 2015, Using the comet and micronucleus assays for genotoxicity studies: a review, Biomed. Pharmacother., 72, 74, 10.1016/j.biopha.2015.04.004 Brondani, 2017, Evaluation of acute and subacute toxicity of hydroethanolic extract of Dolichandra unguis-cati L. leaves in rats, J. Ethnopharmacol., 202, 147, 10.1016/j.jep.2017.03.011 Brown, 2017, An overview of herb and dietary supplement efficacy, safety and government regulations in the United States with suggested improvements. Part 1 of 5 series, Food Chem. Toxicol., 107, 449, 10.1016/j.fct.2016.11.001 Burow, 1998, Differences in susceptibility to tumor necrosis factor alpha-induced apoptosis among MCF-7 breast cancer cell variants, Cancer Res., 58, 4940 Chiang, 2014, Caffeic acid derivatives inhibit the growth of colon cancer: involvement of the PI3-K/Akt and AMPK signaling pathways, PLoS One, 9, 10.1371/journal.pone.0099631 Da Rosa, 2017, Antigenotoxic, antimutagenic and cytoprotective potential of Salvia hispanica L. seed extract on human leukocytes exposed to oxidative damage, J. Funct. Foods, 38, 505, 10.1016/j.jff.2017.09.052 Diarra, 2016, Medicinal plants in type 2 diabetes: therapeutic and economical aspects, Int. J. Prev. Med., 7, 56, 10.4103/2008-7802.178370 Do Nascimento, 2016, Indicações de plantas medicinais realizadas por raizeiros para tratamento de feridas, Rev. Eletr. Enf., 18, 1, 10.5216/ree.v18.31143 Duarte, 2000, Chemical characterization and biological activity of Macfadyena unguis-cati (Bignoniaceae), J. Pharm. Pharmacol., 52, 347, 10.1211/0022357001773904 Duke, 2008 Efferth, 2017, Multiple resistance to carcinogens and xenobiotics: p-glycoproteins as universal detoxifiers, Arch. Toxicol., 91, 2515, 10.1007/s00204-017-1938-5 Flor, 2015, Sabedoria popular no uso de plantas medicinais pelos moradores do bairro do sossego no distrito de Marudá - PA, Rev. Bras. Pl. Med., 17, 757, 10.1590/1983-084X/14_064 Georgé, 2005, Rapid determination of polyphenols and vitamin C in plant-derived products, J. Agric. Food Chem., 53, 1370, 10.1021/jf048396b Gouthamchandra, 2017, Chlorogenic acid complex (CGA7), standardized extract from green coffee beans exerts anticancer effects against cultured human colon cancer HCT-116 cells, Food Sci. Hum. Wellness, 6, 147, 10.1016/j.fshw.2017.06.001 Güez, 2017, Evaluation of basil extract (Ocimum basilicum L.) on oxidative, antigenotoxic and anti-inflammatory effects in human leukocytes cell cultures exposed to challenging agents, Braz. J. Pharm. Sci., 53, 10.1590/s2175-97902017000115098 Heo, 2018, Phytochemical-induced reactive oxygen species and endoplasmic reticulum stress-mediated apoptosis and differentiation in malignant melanoma cells, Phytomedicine, 39, 100, 10.1016/j.phymed.2017.12.006 Lorenzi, 2008 Malheiros, 2017, Preliminary in vitro assessment of the potential toxicity and antioxidant activity of Ceiba speciosa (A. St.-Hill) Ravenna (Paineira), Braz. J. Pharm. Sci., 53, 10.1590/s2175-97902017000216098 Matić, 2013, Methanol extract from the stem of Cotinus coggygria Scop., and its major bioactive phytochemical constituent myricetin modulate pyrogallol-induced DNA damage and liver injury, Mutat. Res., 755, 81, 10.1016/j.mrgentox.2013.03.011 Mors, 2000 Nath, 2015, Acute and sub-acute oral toxicity assessment of the methanolic extract from leaves of Hibiscus rosa-sinensis L. in mice, J. Intercult. Ethnopharmacol., 4, 70, 10.5455/jice.20141028021746 Omokhua, 2018, Noxious to ecosystems, but relevant to pharmacology: four South African alien invasive plants with pharmacological potential, S. Afr. J. Bot., 117, 41, 10.1016/j.sajb.2018.04.015 Pye, 2017, Retrospective analysis of natural products provides insights for future discovery trends, PNAS, 114, 5601, 10.1073/pnas.1614680114 Rio, 1996 Roleira, 2015, Plant derived and dietary phenolic antioxidants: anticancer properties, Food Chem., 183, 235, 10.1016/j.foodchem.2015.03.039 Sak, 2014, Cytotoxicity of dietary flavonoids on different human cancer types, Pharmacogn. Rev., 8, 122, 10.4103/0973-7847.134247 Šamec, 2015, Molecular and cellular approach in the study of antioxidant/pro-oxidant properties of Micromeria croatica (Pers.) Schott, Nat. Prod. Res., 29, 1770, 10.1080/14786419.2014.999334 Singh, 1988, A simple technique for quantitation of low levels of DNA damage in individual cells, Exp. Cell Res., 175, 184, 10.1016/0014-4827(88)90265-0 Siqueira, 2014, Influência de reguladores de crescimento no cultivo in vitro de Dolichandra unguis-cati (L.) L.G. Lohmann a partir de estacas caulinares, Iheringia Ser. Bot., 69, 341 Thomas, 2008, The buccal cytome and micronucleus frequency is substantially altered in Down’s syndrome and normal ageing compared to young healthy controls, Mutat. Res., 638, 37, 10.1016/j.mrfmmm.2007.08.012 Yedjou, 2016, Natural plant extracts induced DNA damage and apoptosis through oxidative stress in transgenic mouse model, Cancer Res., 76, 838, 10.1158/1538-7445.AM2016-838