Detection of interleukin‐6 in human dental pulp and periapical lesions

Dental Traumatology - Tập 15 Số 1 - Trang 26-27 - 1999
Rahmat A. Barkhordar1, Cynthia Hayashi1, Mansoor Hussain1
1Department of Restorative Dentistry, School of Dentistry, University of California at San Francisco, San Francisco, California, USA

Tóm tắt

Abstract— Pulpal and periapical diseases are characterized by inflammation. The cytokine IL‐6 is a major mediator of the host response to tissue injury and infection. This study examined the level of interleukin‐6 (IL‐6) in six inflamed human pulps and six human periapical lesions of endodontic origin using ELISA. Pulp samples from eight clinically impacted teeth were used as controls. The periapical samples exhibited significant levels of IL‐6 (mean= 78.1 ± 9 pg/mg protein) as did inflamed pulpal tissues (mean= 36±3.9 pg/mg protein) compared to healthy pulp (mean= 0.01±0.02 pg/mg protein). These data indicated that IL‐6 was produced and released locally in the inflamed pulpal and periapical lesions.

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Dental Traumatology

Tập 15 Số 1

26-27

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